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Tumor Biology

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01.02.2014 | Research Article

The prognostic value of elevated ezrin in patients with osteosarcoma

verfasst von: Deng-Xing Lun, Yong-Cheng Hu, Zhao-Wan Xu, Li-Na Xu, Bin-Wu Wang

Erschienen in: Tumor Biology | Ausgabe 2/2014

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Abstract

Published studies researching the prognostic significance of ezrin expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis to assess its prognostic value more precisely. The hazard ratios with corresponding 95 % confidence intervals were calculated to evaluate the effects. Five studies with 318 osteosarcoma patients were included to estimate the relationship between ezrin and disease-free survival, and ezrin and overall survival. Compared with osteosarcoma patients with low or negative ezrin expression, patients with high ezrin expression tended to be associated with lower disease-free survival, but the difference was not significant. However, patients with high ezrin expression were obviously associated with lower overall survival. Therefore, the findings from this systematic review suggest that ezrin expression is an effective biomarker of prognosis in patients with osteosarcoma.

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Titel: The prognostic value of elevated ezrin in patients with osteosarcoma
verfasst von: Deng-Xing Lun
Yong-Cheng Hu
Zhao-Wan Xu
Li-Na Xu
Bin-Wu Wang
Publikationsdatum: 01.02.2014
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 2/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-013-1168-2

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The prognostic value of elevated ezrin in patients with osteosarcoma

Abstract

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Abstract

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