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Tumor Biology

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01.08.2014 | Research Article

Association of single-nucleotide polymorphisms in ERCC1 and ERCC2 with glioma risk

verfasst von: Lei Hui, Shuangzhu Yue, Guojun Gao, Haigang Chang, Xiangsheng Li

Erschienen in: Tumor Biology | Ausgabe 8/2014

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Abstract

We conducted a case–control study to assess the role of three single-nucleotide polymorphisms (SNPs) in excision repair cross-complementation group 1 (ERCC1) and two SNPs in excision repair cross-complementation group 2 (ERCC2) on the glioma risk in a Chinese population, and investigate the gene–environmental interaction for the cancer risk. A 1:2 matched case–control study was conducted. Logistic regression analysis revealed that individuals carrying ERCC1 rs2298881 CC genotype were associated with risk of glioma when compared with AA genotype carriers. The significant associations of ERCC1 rs2298881 polymorphism with glioma susceptibility were observed in both the dominant and the recessive models. In a stratification analysis, we found that ERCC1 rs2298881 variants showed an increased association with the risk of glioma in males, ever smokers, and high-grade glioma cases. In conclusion, our study suggests that ERCC1 rs2298881 polymorphism is associated with risk of glioma in codominant, dominant, and recessive models, especially in males, smokers, and high-grade glioma cases. This finding could be useful in revealing the genetic characteristics of glioma and suggests more effective strategies for prevention and treatment.

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Titel: Association of single-nucleotide polymorphisms in ERCC1 and ERCC2 with glioma risk
verfasst von: Lei Hui
Shuangzhu Yue
Guojun Gao
Haigang Chang
Xiangsheng Li
Publikationsdatum: 01.08.2014
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 8/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-1969-y

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Association of single-nucleotide polymorphisms in ERCC1 and ERCC2 with glioma risk

Abstract

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