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Erschienen in: Tumor Biology 11/2014

01.11.2014 | Research Article

miR-144 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting E2F3

verfasst von: Tingjia Cao, Hanjun Li, Yilin Hu, Dandan Ma, Xun Cai

Erschienen in: Tumor Biology | Ausgabe 11/2014

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Abstract

MicroRNAs (miRNAs) play essential roles in the progression of hepatocellular carcinoma (HCC). miR-144 acts as a tumor suppressor in some malignancies, while its role in HCC is unclear. Here, we found that miR-144 was significantly decreased in HCC tissues and cell lines. Forced overexpression of miR-144 remarkably reduced cell proliferation, increased apoptosis, and suppressed migration and invasion of HCC cells. E2F transcription factor 3 (E2F3) was identified as a target of miR-144 in HCC cells. Moreover, E2F3 overexpression partially attenuated the tumor suppressive effects of miR-144, and the expression of E2F3 was negatively correlated with miR-144 level in HCC tissues. Our data suggest that miR-144 might suppress the growth and motility of HCC cells partially by targeting E2F3.
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Metadaten
Titel
miR-144 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting E2F3
verfasst von
Tingjia Cao
Hanjun Li
Yilin Hu
Dandan Ma
Xun Cai
Publikationsdatum
01.11.2014
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 11/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-2017-7

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