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Tumor Biology

Erschienen in:

01.11.2014 | Review

Role of microRNA-93 in regulation of angiogenesis

verfasst von: Fangxuan Li, Xiaofeng Liang, Ying Chen, Shixia Li, Juntian Liu

Erschienen in: Tumor Biology | Ausgabe 11/2014

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Abstract

Angiogenesis is essential for a wide variety of physiological and pathological processes. To date, many angiogenic microRNAs (miRNAs) have been identified and several of them were further investigated to elucidate the mechanisms of specific miRNAs in regulating angiogenesis. In recent studies concerning tumor and ischemia, the miRNA-93 had been demonstrated to be able to modulate angiogenesis in different molecular pathways. The miRNA-93 can promote angiogenesis via enhancing endothelial cell proliferation, migration, and tube formation. Additionally, miRNA-93-over-expressing cells developed a relationship with the blood vessels allowing tumor cells to survive and to grow well. However, high expression of miRNA-93 can depress the vascular endothelial growth factor (VEGF) secretion and its downstream molecular targets in in vivo and vitro experiments. MiRNA-93’s effects on angiogenesis are dependent on the interaction of other multiple genes and signal pathways, such as P21, E2F1, integrin-β8, LATS2, etc. Future investigation should involve mapping the network by which miRNA-93 exerts its functions.

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Titel: Role of microRNA-93 in regulation of angiogenesis
verfasst von: Fangxuan Li
Xiaofeng Liang
Ying Chen
Shixia Li
Juntian Liu
Publikationsdatum: 01.11.2014
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 11/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2605-6

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