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RETRACTED ARTICLE: MicroRNA-495 mimics delivery inhibits lung tumor progression

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  • Published:
Tumor Biology

This article was retracted on 02 November 2016

Abstract

MicroRNAs (miRNAs) can function as tumor suppressors and might provide an efficient strategy for annihilating cancer. Specific miRNAs can be reintroduced into tumor cells to elicit the tumor suppressor activities. We show that systemically delivered, synthetic miRNA mimics in complex with a novel neutral lipid emulsion are preferentially targeted to lung tumors and show therapeutic benefit in mouse models of lung cancer. The delivery was demonstrated using mimics of the tumor suppressor microRNA-495 which is found downregulated in most lung cancer. Systemic treatment of a Kras-activated autochthonous mouse model of non-small cell lung cancer (NSCLC) led to a significant decrease in tumor burden. Specifically, mice treated with microRNA-495 displayed a large reduction in tumor area compared to mice treated with a miRNA control. These findings provide direct evidence that systematically delivered synthetic miRNA mimics to the mammalian lung can inhibit tumor proliferation and support the promise of miRNAs as a targeted therapy for lung cancer in future.

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Authors and Affiliations

  1. Department of Cardiothoracic Surgey, Panzhihua Central Hospital of Sichuan Province, No. 34 Yi Kang Street, Panzhihua, Sichuan, China

    Cheng Ai, Rujian Jiang, Li Fu & Youdong Chen

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  1. Cheng Ai
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  2. Rujian Jiang
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  3. Li Fu
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  4. Youdong Chen
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Corresponding author

Correspondence to Cheng Ai.

Additional information

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-016-5471-6.

The Editor-in-Chief has decided to retract this article. It has been found that the authors have plagiarized substantial parts from another article.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-016-5471-6.

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Ai, C., Jiang, R., Fu, L. et al. RETRACTED ARTICLE: MicroRNA-495 mimics delivery inhibits lung tumor progression. Tumor Biol. 36, 729–735 (2015). https://doi.org/10.1007/s13277-014-2687-1

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  • DOI: https://doi.org/10.1007/s13277-014-2687-1

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