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Tumor Biology

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01.04.2015 | Research Article

miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1

verfasst von: Ye Zhang, Xiujuan Qu, Ce Li, Yibo Fan, Xiaofang Che, Ximing Wang, Ying Cai, Xuejun Hu, Yunpeng Liu

Erschienen in: Tumor Biology | Ausgabe 4/2015

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Abstract

MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs with the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In the present study, we analyzed miRNA expression levels between multidrug-resistant gastric carcinoma cell line SGC7901/ADR and its parent cell line SGC7901 using a miRNA microarray. MiR-103/107 was downregulated compared with parental SGC7901 cells. Overexpression of miR-103/107 sensitized SGC7901/ADR cells to doxorubicin (DOX), as demonstrated by in vitro and in vivo drug sensitivity assay. We further confirmed that miR-103/107 inhibited P-gp function in gastric cancer SGC7901/ADR cells. Finally, we verified that caveolin-1 (Cav-1), a critical component of lipid rafts, was a target of miR-103/107.

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Titel: miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1
verfasst von: Ye Zhang
Xiujuan Qu
Ce Li
Yibo Fan
Xiaofang Che
Ximing Wang
Ying Cai
Xuejun Hu
Yunpeng Liu
Publikationsdatum: 01.04.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 4/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2835-7

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miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1

Abstract

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Abstract

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