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Tumor Biology
Erschienen in: Tumor Biology 3/2015

01.03.2015 | Review

Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal

verfasst von: Suoyuan Li, Wei Sun, Hongsheng Wang, Dongqing Zuo, Yingqi Hua, Zhengdong Cai

Erschienen in: Tumor Biology | Ausgabe 3/2015

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Abstract

Osteosarcoma (OS) is the most common and aggressive primary malignant type of bone cancer in children and adolescents. Chemotherapy is one of the most important treatments for OS. Although cancer therapy has improved over the past few decades, survival outcomes for OS patients remain unsatisfactory. One of the primary reasons for the failure of current treatments is that patients with stage IV cancer often develop resistance to anticancer agents. This article will review multidrug resistance (MDR) mechanisms of OS and strategies for overcoming resistance.
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Metadaten
Titel
Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal
verfasst von
Suoyuan Li
Wei Sun
Hongsheng Wang
Dongqing Zuo
Yingqi Hua
Zhengdong Cai
Publikationsdatum
01.03.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 3/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3181-0

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