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22.10.2015 | Original Article

Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma

verfasst von: Wenjian Yao, Yu Bai, Yan Li, Ling Guo, Ping Zeng, Yonglian Wang, Bo Qi, Shangguo Liu, Xiuguang Qin, Yongzhen Li, Baosheng Zhao

Erschienen in: Tumor Biology | Ausgabe 4/2016

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Abstract

The aim of this study is to investigate whether metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) can be used as a potential therapy target for human esophageal squamous cell carcinoma. MALAT-1 expression levels were detected in 137 paired EC samples and adjacent nonneoplastic tissues. Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase. These data indicates that MALAT-1 could be exploited for therapeutic benefit.

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Titel: Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma
verfasst von: Wenjian Yao
Yu Bai
Yan Li
Ling Guo
Ping Zeng
Yonglian Wang
Bo Qi
Shangguo Liu
Xiuguang Qin
Yongzhen Li
Baosheng Zhao
Publikationsdatum: 22.10.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 4/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4223-3

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Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma

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