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Erschienen in: Tumor Biology 11/2016

12.09.2016 | Original Article

High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma

verfasst von: Xinghua Zhu, Yaxun Wu, Xiaobing Miao, Chunsun Li, Haibing Yin, Shuyun Yang, Xiaoyun Lu, Yushan Liu, Yali Chen, Rong Shen, Xudong Chen, Song He

Erschienen in: Tumor Biology | Ausgabe 11/2016

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Abstract

Dysregulation of TRIM44 has been reported to be involved in tumorigenesis, but its role in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the clinicopathological and biological significance of TRIM44 in HCC. We found that TRIM44 mRNA and protein expression was upregulated in HCC compared with matched normal tissues. Intriguingly, we also found that TRIM44 expression was significantly correlated with tumor size (P < 0.001), vascular invasion (P < 0.001), intrahepatic metastasis (P < 0.001), distant metastasis (P < 0.001), and Ki-67 expression (P < 0.001). Kaplan-Meier analysis showed that high TRIM44 staining was significantly correlated with shorter overall survival (P < 0.001). TRIM44 was an independent predictor of overall survival in patients with HCC. Furthermore, we found that ectopic expression of TRIM44 could promote cell proliferation via accelerating the G1/S-phase transition in HCC. Moreover, overexpression of TRIM44 could enhance the invasive and migratory capacity of HCC cells. Meanwhile, we found that high expression of TRIM44 could enhance resistance of HCC cells to doxorubicin via accelerating NF-κB activation. In conclusion, our results suggest that TRIM44 may be a novel prognostic indicator and potential therapeutic target of HCC.
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Metadaten
Titel
High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma
verfasst von
Xinghua Zhu
Yaxun Wu
Xiaobing Miao
Chunsun Li
Haibing Yin
Shuyun Yang
Xiaoyun Lu
Yushan Liu
Yali Chen
Rong Shen
Xudong Chen
Song He
Publikationsdatum
12.09.2016
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 11/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-5316-3

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