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Erschienen in: Tumor Biology 11/2016

20.09.2016 | Review

Natural products against cancer angiogenesis

verfasst von: El Bairi Khalid, EL-Meghawry EL-Kenawy Ayman, Heshu Rahman, Guaadaoui Abdelkarim, Agnieszka Najda

Erschienen in: Tumor Biology | Ausgabe 11/2016

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Abstract

The process of angiogenesis is quite well-known nowadays. Some medicines and extracts affecting this process are already used routinely in supporting the conventional treatment of many diseases that are considered angiogenic such as cancer. However, we must be aware that the area of currently used drugs of this type is much narrower than the theoretical possibilities existing in therapeutic angiogenesis. Plant substances are a large and diverse group of compounds that are found naturally in fruits, vegetables, spices, and medicinal plants. They also have different anticancer properties. The aim of this literature review article is to present the current state of knowledge concerning the molecular targets of tumor angiogenesis and the active substances (polyphenols, alkaloids, phytohormones, carbohydrates, and terpenes) derived from natural sources, whose activity against cancer angiogenesis has been confirmed.
Literatur
1.
2.
Zurück zum Zitat Ferlay J et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014;136:359–86.CrossRef Ferlay J et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014;136:359–86.CrossRef
3.
4.
Zurück zum Zitat Davis EL. Oh B, Butow PN, Mullan BA, Clarke S. Cancer patient disclosure and patient-doctor communication of complementary and alternative medicine use: a systematic review. Oncologist. 2012;17:1475–81.PubMedPubMedCentralCrossRef Davis EL. Oh B, Butow PN, Mullan BA, Clarke S. Cancer patient disclosure and patient-doctor communication of complementary and alternative medicine use: a systematic review. Oncologist. 2012;17:1475–81.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Harvey AL, Edrada-Ebel RA, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nature Rev. Drug Discov. 2015;14(2):111–29.CrossRef Harvey AL, Edrada-Ebel RA, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nature Rev. Drug Discov. 2015;14(2):111–29.CrossRef
6.
Zurück zum Zitat Wang CZ, He H, Wang X, Yuan CS. Trends in scientific publications of Chinese medicine. Am J Chin Med. 2012;40:1099–108.PubMedCrossRef Wang CZ, He H, Wang X, Yuan CS. Trends in scientific publications of Chinese medicine. Am J Chin Med. 2012;40:1099–108.PubMedCrossRef
7.
Zurück zum Zitat Bell RMA. Review of complementary and alternative medicine practices among cancer survivors. Clin J Oncol Nurs. 2010;14:365–70.PubMedCrossRef Bell RMA. Review of complementary and alternative medicine practices among cancer survivors. Clin J Oncol Nurs. 2010;14:365–70.PubMedCrossRef
9.
Zurück zum Zitat Cragg GM, Grothaus PG, Newman DJ. Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009;109:3012–43.PubMedCrossRef Cragg GM, Grothaus PG, Newman DJ. Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009;109:3012–43.PubMedCrossRef
10.
Zurück zum Zitat Lenzi P, Bocci G, Natale G. John Hunter and the origin of the term “angiogenesis”. Angiogenesis. 2016; 1–2. Lenzi P, Bocci G, Natale G. John Hunter and the origin of the term “angiogenesis”. Angiogenesis. 2016; 1–2.
12.
Zurück zum Zitat Distler JW, Hirth A, Kurowska-Stolarska M, Gay RE, Gay S, Distler O. Angiogenic and angiostatic factors in the molecular control of angiogenesis. Q J Nucl Med. 2003;47:149–61.PubMed Distler JW, Hirth A, Kurowska-Stolarska M, Gay RE, Gay S, Distler O. Angiogenic and angiostatic factors in the molecular control of angiogenesis. Q J Nucl Med. 2003;47:149–61.PubMed
13.
Zurück zum Zitat Kinja K, Rohit S, Mandloi A, Sharma I, Savita S. Anti-angiogenic therapy—past, present and future. Rec Res Sci Tech. 2001;3:8–15. Kinja K, Rohit S, Mandloi A, Sharma I, Savita S. Anti-angiogenic therapy—past, present and future. Rec Res Sci Tech. 2001;3:8–15.
14.
Zurück zum Zitat Shojaei F. Anti-angiogenesis therapy in cancer: current challenges and future perspectives. Cancer Lett. 2012;320:130–7.PubMedCrossRef Shojaei F. Anti-angiogenesis therapy in cancer: current challenges and future perspectives. Cancer Lett. 2012;320:130–7.PubMedCrossRef
15.
Zurück zum Zitat Zielonka TM. Angiogeneza – Część I. Mechanizm powstawania nowych naczyń krwionośnych. Alerg Astma Immun. 2003;8:169–74. Zielonka TM. Angiogeneza – Część I. Mechanizm powstawania nowych naczyń krwionośnych. Alerg Astma Immun. 2003;8:169–74.
16.
Zurück zum Zitat King A, Balaji S, Keswani SG, Crombleholme TM. The role of stem cells in wound angiogenesis. Adv Wound Care (New Rochelle). 2014;3:614–25.CrossRef King A, Balaji S, Keswani SG, Crombleholme TM. The role of stem cells in wound angiogenesis. Adv Wound Care (New Rochelle). 2014;3:614–25.CrossRef
17.
Zurück zum Zitat Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson RS, Kąt N, Cheresh DA. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature. 2008;456(7223):809–13.PubMedPubMedCentralCrossRef Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson RS, Kąt N, Cheresh DA. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature. 2008;456(7223):809–13.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Kurzyk A. Angiogenesis—the possibilities, problems and prospects. Progress Biochemistry. 2015;61(1):25–34 [in Polish]. Kurzyk A. Angiogenesis—the possibilities, problems and prospects. Progress Biochemistry. 2015;61(1):25–34 [in Polish].
19.
Zurück zum Zitat Watt SM, Athanassopoulos A, Harris AL. Human endothelial stem/progenitor cells, angiogenic factors and vascular repair. J R Soc Interface. 2010;7(6):731–51.CrossRef Watt SM, Athanassopoulos A, Harris AL. Human endothelial stem/progenitor cells, angiogenic factors and vascular repair. J R Soc Interface. 2010;7(6):731–51.CrossRef
20.
Zurück zum Zitat Wiśniewski T, Makarewicz R, Ziółkowska E, Rystok D, Zekannowska E. Angiogeneza nowotworowa – mechanizmy, czynniki regulujące, leki. Onkologia Info. 2009;6(5):172–8. Wiśniewski T, Makarewicz R, Ziółkowska E, Rystok D, Zekannowska E. Angiogeneza nowotworowa – mechanizmy, czynniki regulujące, leki. Onkologia Info. 2009;6(5):172–8.
21.
Zurück zum Zitat Namiecińska M, Marciniak K, Nowak JZ. VEGF jako czynnik angiogenny, neurotroficzny i neuroprotekcyjny. Postepy Hig Med Dośw. 2005;59:573–83. Namiecińska M, Marciniak K, Nowak JZ. VEGF jako czynnik angiogenny, neurotroficzny i neuroprotekcyjny. Postepy Hig Med Dośw. 2005;59:573–83.
22.
Zurück zum Zitat Folkman J. Angiogenesis: an organizing principle for drug discovery? Nature Rev Drug Discov. 2007;6:273–86.CrossRef Folkman J. Angiogenesis: an organizing principle for drug discovery? Nature Rev Drug Discov. 2007;6:273–86.CrossRef
23.
Zurück zum Zitat Siemerink MJ, Augustin AJ, Schlingemann RO. Mechanisms of ocular angiogenesis and its molecular mediators. Dev Ophthalmol. 2010;46:4–20.PubMedCrossRef Siemerink MJ, Augustin AJ, Schlingemann RO. Mechanisms of ocular angiogenesis and its molecular mediators. Dev Ophthalmol. 2010;46:4–20.PubMedCrossRef
24.
25.
Zurück zum Zitat Shahneh FZ, Baradaran B, Zamani F, Aghebati-Maleki L. Tumor angiogenesis and anti-angiogenic therapies. Hum Antibodies. 2013;22:15–9.PubMed Shahneh FZ, Baradaran B, Zamani F, Aghebati-Maleki L. Tumor angiogenesis and anti-angiogenic therapies. Hum Antibodies. 2013;22:15–9.PubMed
26.
Zurück zum Zitat Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M. Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc Natl Acad Sci. 2007;104:967–72.PubMedPubMedCentralCrossRef Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M. Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc Natl Acad Sci. 2007;104:967–72.PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Vasudev NS, Reynolds AR. Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis. 2014;17(3):471–94.PubMedPubMedCentralCrossRef Vasudev NS, Reynolds AR. Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis. 2014;17(3):471–94.PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Swift MR, Weinstein BM. Arterial-venous specification during development. Circ Res. 2009;104:576–88.PubMedCrossRef Swift MR, Weinstein BM. Arterial-venous specification during development. Circ Res. 2009;104:576–88.PubMedCrossRef
29.
Zurück zum Zitat Herbert SP, Stainier DY. Molecular control of endothelial cell behavior during blood vessel morphogenesis. Nat Rev Mol Cell Biol. 2011;12:551–64.PubMedPubMedCentralCrossRef Herbert SP, Stainier DY. Molecular control of endothelial cell behavior during blood vessel morphogenesis. Nat Rev Mol Cell Biol. 2011;12:551–64.PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153:543–53.PubMedPubMedCentralCrossRef Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153:543–53.PubMedPubMedCentralCrossRef
31.
Zurück zum Zitat Ferrara N, Gerber HP. The biology of VEGF and its receptors. J Nat Med. 2003;9:669–76.CrossRef Ferrara N, Gerber HP. The biology of VEGF and its receptors. J Nat Med. 2003;9:669–76.CrossRef
32.
33.
Zurück zum Zitat Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003;3:401–10.PubMedCrossRef Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003;3:401–10.PubMedCrossRef
35.
Zurück zum Zitat Zhang J, Li Y. Therapeutic uses of FGFs. Semin Cell Dev Biol. 2015:S1084–9521 (15)00166-4. Zhang J, Li Y. Therapeutic uses of FGFs. Semin Cell Dev Biol. 2015:S1084–9521 (15)00166-4.
36.
Zurück zum Zitat Thomas M, Augustin HG. The role of the angiopoietins in vascular morphogenesis. Angiogenesis. 2009;12(2):125–37.PubMedCrossRef Thomas M, Augustin HG. The role of the angiopoietins in vascular morphogenesis. Angiogenesis. 2009;12(2):125–37.PubMedCrossRef
37.
Zurück zum Zitat Kappou D, Sifakis S, Konstantinidou A, Papantoniou N, Spandidos DA. Role of the angiopoietin/Tie system in pregnancy (review). Exp Ther Med. 2015;9(4):1091–6.PubMedPubMedCentral Kappou D, Sifakis S, Konstantinidou A, Papantoniou N, Spandidos DA. Role of the angiopoietin/Tie system in pregnancy (review). Exp Ther Med. 2015;9(4):1091–6.PubMedPubMedCentral
38.
Zurück zum Zitat Khan KA, Bicknell R. Anti-angiogenic alternatives to VEGF blockade. Clin Exp Metastasis. 2016;33:197–210.PubMedCrossRef Khan KA, Bicknell R. Anti-angiogenic alternatives to VEGF blockade. Clin Exp Metastasis. 2016;33:197–210.PubMedCrossRef
39.
Zurück zum Zitat Holderfield MT, Hughes CCW. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res. 2008;102:637–52.PubMedCrossRef Holderfield MT, Hughes CCW. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res. 2008;102:637–52.PubMedCrossRef
40.
Zurück zum Zitat Roedersheimer M et al. A bone-derived mixture of TGFβ-superfamily members forms a more mature vascular network than bFGF or TGF-β2 in vivo. Angiogenesis. 2006;8(4):327–38.CrossRef Roedersheimer M et al. A bone-derived mixture of TGFβ-superfamily members forms a more mature vascular network than bFGF or TGF-β2 in vivo. Angiogenesis. 2006;8(4):327–38.CrossRef
42.
Zurück zum Zitat Umikawa M, Umikawa A, Asato T, Takei K, Matsuzaki G, Kariya K, Zhang CC. Angiopoietin-like protein 2 induces proinflammatory responses in peritoneal cells. Biochem Biophys Res Commun. 2015;467(2):235–41.PubMedPubMedCentralCrossRef Umikawa M, Umikawa A, Asato T, Takei K, Matsuzaki G, Kariya K, Zhang CC. Angiopoietin-like protein 2 induces proinflammatory responses in peritoneal cells. Biochem Biophys Res Commun. 2015;467(2):235–41.PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Wagner M et al. Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis. 2012;15(3):481–95.PubMedPubMedCentralCrossRef Wagner M et al. Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis. 2012;15(3):481–95.PubMedPubMedCentralCrossRef
44.
Zurück zum Zitat Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell. 2009;16(2):196–208.PubMedCrossRef Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell. 2009;16(2):196–208.PubMedCrossRef
45.
Zurück zum Zitat Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 2007;21(20):2511–24.PubMedCrossRef Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 2007;21(20):2511–24.PubMedCrossRef
46.
Zurück zum Zitat Sainson RCA, Harris AL. Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies. Angiogenesis. 2008;11(1):41–51.PubMedCrossRef Sainson RCA, Harris AL. Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies. Angiogenesis. 2008;11(1):41–51.PubMedCrossRef
47.
Zurück zum Zitat Gorantla B et al. Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma. Angiogenesis. 2013;16(1):85–100.PubMedCrossRef Gorantla B et al. Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma. Angiogenesis. 2013;16(1):85–100.PubMedCrossRef
48.
Zurück zum Zitat Serini G, Maione F, Bussolino F. Semaphorins and tumor angiogenesis. Angiogenesis. 2009;12(2):187–93.PubMedCrossRef Serini G, Maione F, Bussolino F. Semaphorins and tumor angiogenesis. Angiogenesis. 2009;12(2):187–93.PubMedCrossRef
50.
Zurück zum Zitat Geretti E, Shimizu A, Klagsbrun M. Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis. Angiogenesis. 2008;11(1):31–9.PubMedCrossRef Geretti E, Shimizu A, Klagsbrun M. Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis. Angiogenesis. 2008;11(1):31–9.PubMedCrossRef
51.
Zurück zum Zitat Staton CA. Class 3 semaphorins and their receptors in physiological and pathological angiogenesis. Biochem Soc Trans. 2011;39:1565–70.PubMedCrossRef Staton CA. Class 3 semaphorins and their receptors in physiological and pathological angiogenesis. Biochem Soc Trans. 2011;39:1565–70.PubMedCrossRef
52.
Zurück zum Zitat Leszczynska K, Kaur S, Wilson E, Bicknell R, Heath VL. The role of RhoJ in endothelial cell biology and angiogenesis. Biochem Soc Trans. 2011;39:1606–11.PubMedCrossRef Leszczynska K, Kaur S, Wilson E, Bicknell R, Heath VL. The role of RhoJ in endothelial cell biology and angiogenesis. Biochem Soc Trans. 2011;39:1606–11.PubMedCrossRef
55.
Zurück zum Zitat Zhuang X, Cross D, Heath VL, Bicknell R. Shear stress, tip cells and regulators of endothelial migration. Biochem Soc Trans. 2011;39:1571–5.PubMedCrossRef Zhuang X, Cross D, Heath VL, Bicknell R. Shear stress, tip cells and regulators of endothelial migration. Biochem Soc Trans. 2011;39:1571–5.PubMedCrossRef
56.
Zurück zum Zitat Francis ME, Uriel S, Brey EM. Endothelial cell-matrix interactions in neovascularization. Tissue Eng Part B Rev. 2008;14(1):19–32.PubMedCrossRef Francis ME, Uriel S, Brey EM. Endothelial cell-matrix interactions in neovascularization. Tissue Eng Part B Rev. 2008;14(1):19–32.PubMedCrossRef
57.
Zurück zum Zitat Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res. 2005;97(6):512–23.PubMedCrossRef Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res. 2005;97(6):512–23.PubMedCrossRef
58.
Zurück zum Zitat Laurenzana A, Fibbi G, Margheri F, Biagioni A, Luciani C, Del Rosso M, Chillà A. Endothelial progenitor cells in sprouting angiogenesis: proteases pave the way. Curr Mol Med. 2015;15(7):606–20.PubMedCrossRef Laurenzana A, Fibbi G, Margheri F, Biagioni A, Luciani C, Del Rosso M, Chillà A. Endothelial progenitor cells in sprouting angiogenesis: proteases pave the way. Curr Mol Med. 2015;15(7):606–20.PubMedCrossRef
59.
Zurück zum Zitat Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Betsholtz C. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161(6):1163–77.PubMedPubMedCentralCrossRef Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Betsholtz C. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161(6):1163–77.PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Makanya AN, Hlushchuk R, Djonov VG. Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling. Angiogenesis. 2009;12:113–23.PubMedCrossRef Makanya AN, Hlushchuk R, Djonov VG. Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling. Angiogenesis. 2009;12:113–23.PubMedCrossRef
61.
Zurück zum Zitat Gianni-Barrera R et al. VEGF over-expression in skeletal muscle induces angiogenesis by intussusception rather than sprouting. Angiogenesis. 2013;16(1):123–36.PubMedCrossRef Gianni-Barrera R et al. VEGF over-expression in skeletal muscle induces angiogenesis by intussusception rather than sprouting. Angiogenesis. 2013;16(1):123–36.PubMedCrossRef
62.
Zurück zum Zitat VanHinsbergh VW, Koolwijk P. Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead. Cardiovasc Res. 2008;78(2):203–12.CrossRef VanHinsbergh VW, Koolwijk P. Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead. Cardiovasc Res. 2008;78(2):203–12.CrossRef
63.
Zurück zum Zitat Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomaki A, Aranda E, Miura N, Yla-Herttuala S, Fruttiger M, Makinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing notch signalling. Nat Cell Biol. 2011;13:1202–13.PubMedPubMedCentralCrossRef Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomaki A, Aranda E, Miura N, Yla-Herttuala S, Fruttiger M, Makinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing notch signalling. Nat Cell Biol. 2011;13:1202–13.PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Fresco P, Borges F, Diniz C, Marques MPM. New insights on the anticancer properties of dietary polyphenols. Med Res Rev. 2006;26(6):747–66.PubMedCrossRef Fresco P, Borges F, Diniz C, Marques MPM. New insights on the anticancer properties of dietary polyphenols. Med Res Rev. 2006;26(6):747–66.PubMedCrossRef
66.
Zurück zum Zitat Lau ST, Lin ZX, Zhao M, Leung PS. Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines. Phytother Res. 2008;22:477–86.PubMedCrossRef Lau ST, Lin ZX, Zhao M, Leung PS. Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines. Phytother Res. 2008;22:477–86.PubMedCrossRef
67.
Zurück zum Zitat Lee RT, Hlubocky F, Hu JJ, Stafford R, Daugherty C. An international pilot study of oncology physicians? Opinions and practices on complementary and alternative medicine (CAM). Integr Cancer Ther. 2008;7(2):70–5.PubMedCrossRef Lee RT, Hlubocky F, Hu JJ, Stafford R, Daugherty C. An international pilot study of oncology physicians? Opinions and practices on complementary and alternative medicine (CAM). Integr Cancer Ther. 2008;7(2):70–5.PubMedCrossRef
68.
Zurück zum Zitat Lee SM, Kwon JI, Choi YH, Eom HS, Chi GY. Induction of G2/M arrest and apoptosis by water extract of Strychni semen in human gastric carcinoma AGS cells. Phytother Res. 2008;22(6):752–8.PubMedCrossRef Lee SM, Kwon JI, Choi YH, Eom HS, Chi GY. Induction of G2/M arrest and apoptosis by water extract of Strychni semen in human gastric carcinoma AGS cells. Phytother Res. 2008;22(6):752–8.PubMedCrossRef
69.
Zurück zum Zitat Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho CW, Chan K, Wang YT, Luo GA, Ziche M, Presta M, Charnock-Jones DS, Fan TP. The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo. Angiogenesis. 2011;14(2):187–97.PubMedCrossRef Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho CW, Chan K, Wang YT, Luo GA, Ziche M, Presta M, Charnock-Jones DS, Fan TP. The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo. Angiogenesis. 2011;14(2):187–97.PubMedCrossRef
70.
Zurück zum Zitat Rasul A, Yu B, Khan M, Zhang K, Iqbal F, Ma T, Yang H. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol. 2012;40(4):1153–61.PubMed Rasul A, Yu B, Khan M, Zhang K, Iqbal F, Ma T, Yang H. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol. 2012;40(4):1153–61.PubMed
71.
Zurück zum Zitat Lumlerdkij N et al. Cytotoxicity of medicinal plants used in cancer prevention in Thailand. Planta Med. 2015;81(16) PW_31. Lumlerdkij N et al. Cytotoxicity of medicinal plants used in cancer prevention in Thailand. Planta Med. 2015;81(16) PW_31.
72.
Zurück zum Zitat Mehta HJ, Patel V, Sadikot RT. Curcumin and lung cancer—a review. Target Oncol. 2014;9(4):295–310.PubMedCrossRef Mehta HJ, Patel V, Sadikot RT. Curcumin and lung cancer—a review. Target Oncol. 2014;9(4):295–310.PubMedCrossRef
73.
Zurück zum Zitat de Vogel S, Dindore V, van Engeland M, Goldbohm RA, van den Brandt PA, Weijenberg MP. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr. 2008;138:2372–8.PubMedCrossRef de Vogel S, Dindore V, van Engeland M, Goldbohm RA, van den Brandt PA, Weijenberg MP. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr. 2008;138:2372–8.PubMedCrossRef
75.
Zurück zum Zitat Danciu C, Avram S, Gaje P, Pop G, Şoica C, Craina M, Dumitru C, Dehelean C, Peev C. An evaluation of three nutraceutical species in the Apiaceae family from the western part of Romania: antiproliferative and antiangiogenic potential. J Agroalimentary Processes Technol. 2013;19(2):173–9. Danciu C, Avram S, Gaje P, Pop G, Şoica C, Craina M, Dumitru C, Dehelean C, Peev C. An evaluation of three nutraceutical species in the Apiaceae family from the western part of Romania: antiproliferative and antiangiogenic potential. J Agroalimentary Processes Technol. 2013;19(2):173–9.
76.
Zurück zum Zitat Sauer, Heinrich, et al. Herbal ingredients for the inhibition of tumour-induced angiogenesis. Botanical Medicine in Clinical Practice. 2008. p. 335. Sauer, Heinrich, et al. Herbal ingredients for the inhibition of tumour-induced angiogenesis. Botanical Medicine in Clinical Practice. 2008. p. 335.
77.
Zurück zum Zitat Carvalho AA, Costa PMD, Vieira GC, Jamacaru FVF, Moraes MO, Cavalcanti BC, Pessoa C. Natural products used as candidates for angiogenesis inhibitors in cancer therapy. Trends Org Chem. 2011;15:79–93. Carvalho AA, Costa PMD, Vieira GC, Jamacaru FVF, Moraes MO, Cavalcanti BC, Pessoa C. Natural products used as candidates for angiogenesis inhibitors in cancer therapy. Trends Org Chem. 2011;15:79–93.
78.
Zurück zum Zitat Dudkowska M, Kucharewicz K. Natural compounds—modulators of senescence and cell death. Postępy Biochemii. 2014;60(2):207–20.PubMed Dudkowska M, Kucharewicz K. Natural compounds—modulators of senescence and cell death. Postępy Biochemii. 2014;60(2):207–20.PubMed
79.
Zurück zum Zitat Lin W, Zhao J, Cao Z, Zhuang Q, Zheng L, Zeng J, Hong Z, Peng J. Livistona chinensis seeds inhibit hepatocellular carcinoma angiogenesis in vivo via suppression of the Notch pathway. Oncol Rep. 2014;31:1723–8.PubMed Lin W, Zhao J, Cao Z, Zhuang Q, Zheng L, Zeng J, Hong Z, Peng J. Livistona chinensis seeds inhibit hepatocellular carcinoma angiogenesis in vivo via suppression of the Notch pathway. Oncol Rep. 2014;31:1723–8.PubMed
81.
Zurück zum Zitat Jennifer AD, Jennifer EH, Gerald EH. Role of apoptosis in anti-angiogenic cancer therapies. In: Gewirtz DA, Holt SE, Grant S, editors. Apoptosis, senescence and cancer. New York: Humana Press Inc.; 2007. p. 537–56. Jennifer AD, Jennifer EH, Gerald EH. Role of apoptosis in anti-angiogenic cancer therapies. In: Gewirtz DA, Holt SE, Grant S, editors. Apoptosis, senescence and cancer. New York: Humana Press Inc.; 2007. p. 537–56.
82.
Zurück zum Zitat Millimouno FM, Dong J, Yang L, Li J, Li X. Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Am Assoc Cancer Res. 2014;8(26):1–27. Millimouno FM, Dong J, Yang L, Li J, Li X. Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Am Assoc Cancer Res. 2014;8(26):1–27.
83.
Zurück zum Zitat Ludwiczuk A, Najda A, Wolski T, Baj T. Chromatographic determination of the content and the composition of extracts and essential oils from the fruits of three varieties of stalk celery (Apium graveolens L. var dulce Mill. Pers.). JPC-J Planar Chromat. 2001;14(6):400–4. Ludwiczuk A, Najda A, Wolski T, Baj T. Chromatographic determination of the content and the composition of extracts and essential oils from the fruits of three varieties of stalk celery (Apium graveolens L. var dulce Mill. Pers.). JPC-J Planar Chromat. 2001;14(6):400–4.
84.
Zurück zum Zitat Buczkowska H, Dyduch J, Najda A. Capsaicinoids in hot pepper depending on fruit maturity stage and harvest date. Acta Sci Pol-Hortorum Cultus. 2013;6:183–96. Buczkowska H, Dyduch J, Najda A. Capsaicinoids in hot pepper depending on fruit maturity stage and harvest date. Acta Sci Pol-Hortorum Cultus. 2013;6:183–96.
85.
Zurück zum Zitat Kapłan M, Najda A. Antioxidant activity of vine fruits depending on their colouring. Chemija. 2014;25(1):51–5. Kapłan M, Najda A. Antioxidant activity of vine fruits depending on their colouring. Chemija. 2014;25(1):51–5.
86.
Zurück zum Zitat Chinembiri TN, du Plessis LH, Gerber M, Hamman JH, du Plessis J. Review of natural compounds for potential skin cancer treatment. Molecules. 2014;19:11679–721.PubMedCrossRef Chinembiri TN, du Plessis LH, Gerber M, Hamman JH, du Plessis J. Review of natural compounds for potential skin cancer treatment. Molecules. 2014;19:11679–721.PubMedCrossRef
87.
Zurück zum Zitat Najda A, Dyduch-Siemińska M, Dyduch J, Gantner M. Comparative analysis of secondary metabolites contents in Fragaria vesca L. fruits. Ann Agric Envir Med. 2014;21(2):339–43.CrossRef Najda A, Dyduch-Siemińska M, Dyduch J, Gantner M. Comparative analysis of secondary metabolites contents in Fragaria vesca L. fruits. Ann Agric Envir Med. 2014;21(2):339–43.CrossRef
88.
Zurück zum Zitat Najda A, Dyduch J, Świca K, Kapłan M, Papliński R, Sachadyn-Król M, Klimek K. Identification and profile of furanocoumarins from the ribbed celery (Apium graveolens L. Var. dulce mill. / Pers.). Food Sci Tech Res. 2015;21(1). Najda A, Dyduch J, Świca K, Kapłan M, Papliński R, Sachadyn-Król M, Klimek K. Identification and profile of furanocoumarins from the ribbed celery (Apium graveolens L. Var. dulce mill. / Pers.). Food Sci Tech Res. 2015;21(1).
89.
Zurück zum Zitat Najda A. Toxic substances in plants with built structure with nitrogen. Episteme. 2014;25(1):65–76. Najda A. Toxic substances in plants with built structure with nitrogen. Episteme. 2014;25(1):65–76.
90.
Zurück zum Zitat Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012;39:283–99.PubMedPubMedCentralCrossRef Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012;39:283–99.PubMedPubMedCentralCrossRef
91.
92.
Zurück zum Zitat Qiu Y, Yu T, Wang W, Pan K, Shi D, Sun H. Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening. BiochemBiophys Res Commun. 2014;448:15–21.CrossRef Qiu Y, Yu T, Wang W, Pan K, Shi D, Sun H. Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening. BiochemBiophys Res Commun. 2014;448:15–21.CrossRef
93.
Zurück zum Zitat Martinez RM, Pinho-Ribeiro FA, Steffen VS, Silva TC, Caviglione CV, Bottura C, Fonseca MJ, Vicentini FT, Vignoli JA, Baracat MM, Georgetti SR, Verri Jr WA, Casagrande R. Topical formulation containing naringenin: efficacy against ultraviolet b irradiation-induced skin inflammation and oxidative stress in mice. PLoS One. 2016;11(1). doi:10.1371/journal.pone.0146296. Martinez RM, Pinho-Ribeiro FA, Steffen VS, Silva TC, Caviglione CV, Bottura C, Fonseca MJ, Vicentini FT, Vignoli JA, Baracat MM, Georgetti SR, Verri Jr WA, Casagrande R. Topical formulation containing naringenin: efficacy against ultraviolet b irradiation-induced skin inflammation and oxidative stress in mice. PLoS One. 2016;11(1). doi:10.​1371/​journal.​pone.​0146296.
94.
Zurück zum Zitat Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol. 2002;40(8):1091–7.PubMedCrossRef Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol. 2002;40(8):1091–7.PubMedCrossRef
95.
Zurück zum Zitat Najda A, Błaszczyk L, Winiarczyk K, Dyduch J, Tchórzewska D. Comparative studies of nutritional and health-enhancing properties in the “garlic-like” plant Allium ampeloprasum var. ampeloprasum (GHG-L) and A. sativum. Sci Horticulturae. 2016;201:247–55.CrossRef Najda A, Błaszczyk L, Winiarczyk K, Dyduch J, Tchórzewska D. Comparative studies of nutritional and health-enhancing properties in the “garlic-like” plant Allium ampeloprasum var. ampeloprasum (GHG-L) and A. sativum. Sci Horticulturae. 2016;201:247–55.CrossRef
96.
Zurück zum Zitat Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods HumNutr. 2010;65:158–63.CrossRef Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods HumNutr. 2010;65:158–63.CrossRef
97.
Zurück zum Zitat Petiwala SM, Berhe S, Li G, Puthenveetil AG, Rahman O, Nonn L, Johnson JJ. Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth. PLoS One. 2014;9:e89772.PubMedPubMedCentralCrossRef Petiwala SM, Berhe S, Li G, Puthenveetil AG, Rahman O, Nonn L, Johnson JJ. Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth. PLoS One. 2014;9:e89772.PubMedPubMedCentralCrossRef
98.
Zurück zum Zitat Kwon H.J., Shim J.S., Kim J.H., Cho H.Y., Yum Y.N., Kim S.H., Yu J. Betulinic acid inhibits growth factor-induced angiogenesis via the modulation of mitochondrial function in endothelial cells. Jpn J Cancer Res 2002; 93(4): 417–425. Kwon H.J., Shim J.S., Kim J.H., Cho H.Y., Yum Y.N., Kim S.H., Yu J. Betulinic acid inhibits growth factor-induced angiogenesis via the modulation of mitochondrial function in endothelial cells. Jpn J Cancer Res 2002; 93(4): 417–425.
99.
Zurück zum Zitat Shimamura M, Hazato T, Ashino H, Yamamoto Y, Iwasaki E, Tobe H, Yamamoto K, Yamamoto S. Inhibition of angiogenesis by humulone; a bitter acid from beer hop. Biochem.Biophys. Res. Commun. 2001;289(1):220–4.PubMedCrossRef Shimamura M, Hazato T, Ashino H, Yamamoto Y, Iwasaki E, Tobe H, Yamamoto K, Yamamoto S. Inhibition of angiogenesis by humulone; a bitter acid from beer hop. Biochem.Biophys. Res. Commun. 2001;289(1):220–4.PubMedCrossRef
100.
Zurück zum Zitat Shukla Y, Singh R. Resveratrol and cellular mechanisms of cancer prevention. Ann N Y Acad Sci. 2011;1215:1–8.PubMedCrossRef Shukla Y, Singh R. Resveratrol and cellular mechanisms of cancer prevention. Ann N Y Acad Sci. 2011;1215:1–8.PubMedCrossRef
101.
Zurück zum Zitat Shen T, Xie CF, Wang XN, Luo HX. Stilbenoids. In: Ramawat KG, Merillon JM, editors. Natural products. Berlin: Springer; 2013. p. 1901–49.CrossRef Shen T, Xie CF, Wang XN, Luo HX. Stilbenoids. In: Ramawat KG, Merillon JM, editors. Natural products. Berlin: Springer; 2013. p. 1901–49.CrossRef
102.
Zurück zum Zitat Foitzik T, Hotz HG, Hotz B, Wittig F, Buhr HJ. Selective inhibition of cyclooxygenase-2 (COX-2) reduces prostaglandin E2 production and attenuates systemic disease sequelae in experimental pancreatitis. Hepato-Gastroenterology. 2003;50(52):1159–62.PubMed Foitzik T, Hotz HG, Hotz B, Wittig F, Buhr HJ. Selective inhibition of cyclooxygenase-2 (COX-2) reduces prostaglandin E2 production and attenuates systemic disease sequelae in experimental pancreatitis. Hepato-Gastroenterology. 2003;50(52):1159–62.PubMed
103.
Zurück zum Zitat Höper MM, Voelkel NF, Bates TQ, Allard JD, Horan M, Shepherd D, Tudier R. Prostaglandin induce VEGF growth factor in human monocytic cell lines and rat lungs via cAMP. Am J Respir Cell Mol Biol. 1997;17(6):748–56.PubMedCrossRef Höper MM, Voelkel NF, Bates TQ, Allard JD, Horan M, Shepherd D, Tudier R. Prostaglandin induce VEGF growth factor in human monocytic cell lines and rat lungs via cAMP. Am J Respir Cell Mol Biol. 1997;17(6):748–56.PubMedCrossRef
104.
Zurück zum Zitat Li T, Hu J, Du S, Chen Y, Wang S, Wu Q. ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes. Mol Vis. 2014;20:1109–21.PubMedPubMedCentral Li T, Hu J, Du S, Chen Y, Wang S, Wu Q. ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes. Mol Vis. 2014;20:1109–21.PubMedPubMedCentral
105.
Zurück zum Zitat Romano M, Claria J. Cyclooxygenase-2 and 5-lipoxygenase converging function on cell proliferation and angiogenesis: implication for cancer therapy. FASEB J. 2003;17(14):1986–95.PubMedCrossRef Romano M, Claria J. Cyclooxygenase-2 and 5-lipoxygenase converging function on cell proliferation and angiogenesis: implication for cancer therapy. FASEB J. 2003;17(14):1986–95.PubMedCrossRef
107.
Zurück zum Zitat Bardia A, Barton DL, Prokop LJ, Bauer BA, Moynihan TJ. Efficacy of complementary and alternative medicine therapies in relieving cancer pain: a systematic review. Am Soc Clin Oncol. 2006;24(34):5457–64.CrossRef Bardia A, Barton DL, Prokop LJ, Bauer BA, Moynihan TJ. Efficacy of complementary and alternative medicine therapies in relieving cancer pain: a systematic review. Am Soc Clin Oncol. 2006;24(34):5457–64.CrossRef
108.
Zurück zum Zitat Castillo-Pichardo L, Dharmawardhane SF. Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Nutr Cancer. 2012;64:1058–69.PubMedPubMedCentralCrossRef Castillo-Pichardo L, Dharmawardhane SF. Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Nutr Cancer. 2012;64:1058–69.PubMedPubMedCentralCrossRef
109.
Zurück zum Zitat Huang S et al. Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling. Nutr Res. 2012;32(7):530–6.PubMedCrossRef Huang S et al. Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling. Nutr Res. 2012;32(7):530–6.PubMedCrossRef
110.
Zurück zum Zitat Taraphdar AK, Roy M, Bhattacharya RK. Natural products as inducers of apoptosis: implication for cancer therapy and prevention. Current Sci. 2001;80:1387–96. Taraphdar AK, Roy M, Bhattacharya RK. Natural products as inducers of apoptosis: implication for cancer therapy and prevention. Current Sci. 2001;80:1387–96.
111.
Zurück zum Zitat Molassiotis A, Fernandez-Ortega P, Pud D, Ozden G, Scott JA, Panteli V, Margulies A, Browall M, Magri M, Selvekerova S. Use of complementary and alternative medicine in cancer patients: a European survey. Ann Oncol. 2005;16:655–63.PubMedCrossRef Molassiotis A, Fernandez-Ortega P, Pud D, Ozden G, Scott JA, Panteli V, Margulies A, Browall M, Magri M, Selvekerova S. Use of complementary and alternative medicine in cancer patients: a European survey. Ann Oncol. 2005;16:655–63.PubMedCrossRef
112.
Zurück zum Zitat Loboda A, Cisowaski J, Zarebski A, Jazwa A, Rivera Nunez D, Kyprotakis Z, Heinrich M, Dulak J. Effect of plant extracts on angiogenic activities of endothelial cells and keratinomycetes. J Physiol Pharmacol. 2005;1:125–37. Loboda A, Cisowaski J, Zarebski A, Jazwa A, Rivera Nunez D, Kyprotakis Z, Heinrich M, Dulak J. Effect of plant extracts on angiogenic activities of endothelial cells and keratinomycetes. J Physiol Pharmacol. 2005;1:125–37.
113.
Zurück zum Zitat Lamy S, Akla N, Ouanouki A, Lord-Dufour S, Béliveau R. Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway. Exp Cell Res. 2012;318(13):1586–96.PubMedCrossRef Lamy S, Akla N, Ouanouki A, Lord-Dufour S, Béliveau R. Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway. Exp Cell Res. 2012;318(13):1586–96.PubMedCrossRef
114.
115.
Zurück zum Zitat Ribatti D, Nico B, Vacca A, Roncali L, Djonov V. Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and antiangiogenesis in vivo. Ant Rec. 2001;264:317–24.CrossRef Ribatti D, Nico B, Vacca A, Roncali L, Djonov V. Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and antiangiogenesis in vivo. Ant Rec. 2001;264:317–24.CrossRef
116.
Zurück zum Zitat Durupt F, Koppers-Lalic D, Balme B, Budel L, Terrier O, Lina B, Thomas L, Hoeben RC, Rosa-Calatrava M. The chicken chorioallantoic membrane tumor assay as model for qualitative testing of oncolytic adenoviruses. Cancer Gene Ther. 2012;19:58–68.PubMedCrossRef Durupt F, Koppers-Lalic D, Balme B, Budel L, Terrier O, Lina B, Thomas L, Hoeben RC, Rosa-Calatrava M. The chicken chorioallantoic membrane tumor assay as model for qualitative testing of oncolytic adenoviruses. Cancer Gene Ther. 2012;19:58–68.PubMedCrossRef
117.
Zurück zum Zitat Hsin CH, Wu BC, Chuang CY, Yang SF, Hsieh YH, Ho HY, Lin HP, Chen MK, Lin CW. Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells. BMC Complement Altern Med. 2013;13:234–45.PubMedPubMedCentralCrossRef Hsin CH, Wu BC, Chuang CY, Yang SF, Hsieh YH, Ho HY, Lin HP, Chen MK, Lin CW. Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells. BMC Complement Altern Med. 2013;13:234–45.PubMedPubMedCentralCrossRef
118.
Zurück zum Zitat Yi JM, Park JS, Oh SM, Lee J, Kim J, Oh DS, Bang OS, Kim NS. Ethanol extract of Gleditsia sinensis thorn suppresses angiogenesis in vitro and in vivo. BMC ComplementAltern Med. 2012;12:243–51. Yi JM, Park JS, Oh SM, Lee J, Kim J, Oh DS, Bang OS, Kim NS. Ethanol extract of Gleditsia sinensis thorn suppresses angiogenesis in vitro and in vivo. BMC ComplementAltern Med. 2012;12:243–51.
119.
Zurück zum Zitat Kim EC, Kim SH, Piao SJ, Kim TJ, Bae k, Kim HS, Hong SS, Lee BI, Nam M. Antiangiogenic activity of Acer tegmentosum Maxim water extract in vitro and in vivo. J Korean Med Sci. 2015;30:979–87.PubMedPubMedCentralCrossRef Kim EC, Kim SH, Piao SJ, Kim TJ, Bae k, Kim HS, Hong SS, Lee BI, Nam M. Antiangiogenic activity of Acer tegmentosum Maxim water extract in vitro and in vivo. J Korean Med Sci. 2015;30:979–87.PubMedPubMedCentralCrossRef
120.
Zurück zum Zitat Najda A. Planning and evaluation of phytochemical plants in various growth phases of two varieties of celery (Apium graveolens L. var dulce Mil./Pers.). 2004; PhD Dissertation, University of Life Sciences in Lublin. Najda A. Planning and evaluation of phytochemical plants in various growth phases of two varieties of celery (Apium graveolens L. var dulce Mil./Pers.). 2004; PhD Dissertation, University of Life Sciences in Lublin.
122.
Zurück zum Zitat Zhang T, Jia W, Sun X. 3-n-Butylphthalide (NBP) reduces apoptosis and enhances vascular endothelial growth factor (VEGF) up-regulation in diabetic rats. Neurol Res. 2010;32:390–6.PubMedCrossRef Zhang T, Jia W, Sun X. 3-n-Butylphthalide (NBP) reduces apoptosis and enhances vascular endothelial growth factor (VEGF) up-regulation in diabetic rats. Neurol Res. 2010;32:390–6.PubMedCrossRef
123.
Zurück zum Zitat Tai J, Cheung S, Wu M, Hasman D. Antiproliferation effect of rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Phytomed. 2012;19:436–43.CrossRef Tai J, Cheung S, Wu M, Hasman D. Antiproliferation effect of rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Phytomed. 2012;19:436–43.CrossRef
124.
Zurück zum Zitat Petiwala SM, Johnson JJ. Diterpenes from rosemary (Rosmarinus officinalis): defining their potential for anti-cancer activity. Cancer Lett. 2015;367:93–102.PubMedCrossRef Petiwala SM, Johnson JJ. Diterpenes from rosemary (Rosmarinus officinalis): defining their potential for anti-cancer activity. Cancer Lett. 2015;367:93–102.PubMedCrossRef
125.
Zurück zum Zitat Agostinis P, Vantieghem A, Merlevede W, de Witte PAM. Hypericin in cancer 85 treatment: more light on the way. Int J Biochem Cell Biol. 2002;34:221–41.PubMedCrossRef Agostinis P, Vantieghem A, Merlevede W, de Witte PAM. Hypericin in cancer 85 treatment: more light on the way. Int J Biochem Cell Biol. 2002;34:221–41.PubMedCrossRef
126.
Zurück zum Zitat Carimi F, Zottini M, Formentin E, Terzi M, Lo Schiavo F. Cytokinins: new apoptotic inducers in plants. Planta. 2003;216:413–21.PubMed Carimi F, Zottini M, Formentin E, Terzi M, Lo Schiavo F. Cytokinins: new apoptotic inducers in plants. Planta. 2003;216:413–21.PubMed
127.
Zurück zum Zitat Kuttan G., Pratheeshkumar P., Manu K.A,, Kuttan R. Inhibition of tumor progression by naturally occurring terpenoids. Pharm Biol 2011; 49: 995–1007.PubMedCrossRef Kuttan G., Pratheeshkumar P., Manu K.A,, Kuttan R. Inhibition of tumor progression by naturally occurring terpenoids. Pharm Biol 2011; 49: 995–1007.PubMedCrossRef
128.
Zurück zum Zitat Batra P, Sharma AK. Anti-cancer potential of flavonoids: recent trends and future perspectives. Biotech. 2013;3:439–59. Batra P, Sharma AK. Anti-cancer potential of flavonoids: recent trends and future perspectives. Biotech. 2013;3:439–59.
129.
Zurück zum Zitat Parikh NR, Mandal A, Bhatia D, Siveen KS, Sethi G, Bishayee A. Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives. Phytochem Rev. 2014;13:793–810.PubMedPubMedCentralCrossRef Parikh NR, Mandal A, Bhatia D, Siveen KS, Sethi G, Bishayee A. Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives. Phytochem Rev. 2014;13:793–810.PubMedPubMedCentralCrossRef
130.
Zurück zum Zitat Albini A et al. Cancer prevention by targeting angiogenesis. Nat Rev Clin Oncol. 2012;9(9):498–509.PubMedCrossRef Albini A et al. Cancer prevention by targeting angiogenesis. Nat Rev Clin Oncol. 2012;9(9):498–509.PubMedCrossRef
131.
Zurück zum Zitat Weng CJ, Yen GC. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treatment Rev. 2012;38:76–87.CrossRef Weng CJ, Yen GC. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treatment Rev. 2012;38:76–87.CrossRef
132.
Zurück zum Zitat Beghlal D, El Bairi K, Marmouzi I, Haddar L, Mohamed B. Phytochemical, organoleptic and ferric reducing properties of essential oil and ethanolic extract from Pistacia lentiscus (L.). Asian Pac J Trop Dis. 2016;6(4):305–10.CrossRef Beghlal D, El Bairi K, Marmouzi I, Haddar L, Mohamed B. Phytochemical, organoleptic and ferric reducing properties of essential oil and ethanolic extract from Pistacia lentiscus (L.). Asian Pac J Trop Dis. 2016;6(4):305–10.CrossRef
133.
Zurück zum Zitat Koohpar ZK, Entezari M, Movafagh A, Hashem M. Anticancer activity of curcumin on human breast adenocarcinoma: role of mcl-1 gene. Iran J Cancer Prev. 2015;8(3):e2331. Koohpar ZK, Entezari M, Movafagh A, Hashem M. Anticancer activity of curcumin on human breast adenocarcinoma: role of mcl-1 gene. Iran J Cancer Prev. 2015;8(3):e2331.
134.
Zurück zum Zitat Wolanin K, Piwocka K. Curcumin - from natural medicine clinic. Kosmos. 2008;57:53–65. Wolanin K, Piwocka K. Curcumin - from natural medicine clinic. Kosmos. 2008;57:53–65.
135.
Zurück zum Zitat Kumaravel M, Sankar P, Rukkuma-Ni R. Antiproliferative efect of an analog of curcumin bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione in human breast cancer cells. Eur Rev Med Pharmacol Sci. 2012;16:1900–7.PubMed Kumaravel M, Sankar P, Rukkuma-Ni R. Antiproliferative efect of an analog of curcumin bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione in human breast cancer cells. Eur Rev Med Pharmacol Sci. 2012;16:1900–7.PubMed
136.
Zurück zum Zitat Devasena T, Rajasekarana KN, Menon VP. Bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione (a curcumin analog) ameliorates DMH-induced hepatic oxidative stressduring colon carcinogenesis. Pharmacol Res. 2002;46:39–45.PubMedCrossRef Devasena T, Rajasekarana KN, Menon VP. Bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione (a curcumin analog) ameliorates DMH-induced hepatic oxidative stressduring colon carcinogenesis. Pharmacol Res. 2002;46:39–45.PubMedCrossRef
137.
Zurück zum Zitat Mohankumar K, Pajaniradje S, Sridharan S, Kumar Singh V, Ronsard L, Banerjea AC, Selvanesan Benson C, Selvaraj Coumar M, Rajagopalan R. Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin—an in vitro and in silico approach. Chem Biol Interact. 2014;210:51–63.PubMedCrossRef Mohankumar K, Pajaniradje S, Sridharan S, Kumar Singh V, Ronsard L, Banerjea AC, Selvanesan Benson C, Selvaraj Coumar M, Rajagopalan R. Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin—an in vitro and in silico approach. Chem Biol Interact. 2014;210:51–63.PubMedCrossRef
138.
Zurück zum Zitat Srinivasan M, Sudheer AR, Menon VP. Ferulic acid: therapeutic potential through its antioxidant property. J Clinic Biochem Nutr. 2007;40:92–100.CrossRef Srinivasan M, Sudheer AR, Menon VP. Ferulic acid: therapeutic potential through its antioxidant property. J Clinic Biochem Nutr. 2007;40:92–100.CrossRef
139.
Zurück zum Zitat Ho K, Yazan LS, Ismail N, Ismail M. Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin. Cancer Epidem. 2009;33:155–60.CrossRef Ho K, Yazan LS, Ismail N, Ismail M. Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin. Cancer Epidem. 2009;33:155–60.CrossRef
140.
Zurück zum Zitat Lirdprapamongkol K, Sakurai H, Kawasaki N, Choo MK, Saitoh Y, Aozukay Y, Singhirunnusorn P, Ruchirawat S, Svasti J, Saiki I. Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci. 2005;25:57–65.PubMedCrossRef Lirdprapamongkol K, Sakurai H, Kawasaki N, Choo MK, Saitoh Y, Aozukay Y, Singhirunnusorn P, Ruchirawat S, Svasti J, Saiki I. Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci. 2005;25:57–65.PubMedCrossRef
141.
Zurück zum Zitat Nakazato T, Ito K, Ikeda Y, Kizaki M. Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clinic Cancer Res. 2005;11:6040–9.CrossRef Nakazato T, Ito K, Ikeda Y, Kizaki M. Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clinic Cancer Res. 2005;11:6040–9.CrossRef
142.
Zurück zum Zitat Cheung S, Tai J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep. 2007;17:1525–31.PubMed Cheung S, Tai J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep. 2007;17:1525–31.PubMed
143.
Zurück zum Zitat Bai N, He K, Roller M, Lai CS, Shao X, Pan MH, Ho CT. Flavonoids and phenolic compounds from Rosmarinus officinalis. J Agric Food Chem. 2010;58:5363–7.PubMedCrossRef Bai N, He K, Roller M, Lai CS, Shao X, Pan MH, Ho CT. Flavonoids and phenolic compounds from Rosmarinus officinalis. J Agric Food Chem. 2010;58:5363–7.PubMedCrossRef
144.
Zurück zum Zitat Mulinacci N, Innocenti M, Bellumori M, Giaccherini C, Martini V, Michelozzi M. Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: an HPLC/DAD/MS study. Talanta. 2011;85:167–76.PubMedCrossRef Mulinacci N, Innocenti M, Bellumori M, Giaccherini C, Martini V, Michelozzi M. Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: an HPLC/DAD/MS study. Talanta. 2011;85:167–76.PubMedCrossRef
145.
Zurück zum Zitat Bernardes WA, Lucarini R, Tozatti MG, Souza MG, Silva ML, Filho AA, et al. Antimicrobial activity of Rosmarinus officinalis against oral pathogens: relevance of carnosic acid and carnosol. Chem Biodivers. 2010;7:1835–40.PubMedCrossRef Bernardes WA, Lucarini R, Tozatti MG, Souza MG, Silva ML, Filho AA, et al. Antimicrobial activity of Rosmarinus officinalis against oral pathogens: relevance of carnosic acid and carnosol. Chem Biodivers. 2010;7:1835–40.PubMedCrossRef
147.
Zurück zum Zitat Nabekura T, Yamaki T, Hiroi T, Ueno K, Kitagawa S. Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. Pharmacol Res. 2010;61:259–63.PubMedCrossRef Nabekura T, Yamaki T, Hiroi T, Ueno K, Kitagawa S. Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. Pharmacol Res. 2010;61:259–63.PubMedCrossRef
148.
Zurück zum Zitat Yu YM, Lin CH, Chan HC, Tsai HD. Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells. Eur J Nutr. 2009;48:101–6.PubMedCrossRef Yu YM, Lin CH, Chan HC, Tsai HD. Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells. Eur J Nutr. 2009;48:101–6.PubMedCrossRef
150.
Zurück zum Zitat López-Jiménez A, García-Caballero M, Medina MA, Quesada AR. Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. Eur J Nutri. 2013;51(1):85–95.CrossRef López-Jiménez A, García-Caballero M, Medina MA, Quesada AR. Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. Eur J Nutri. 2013;51(1):85–95.CrossRef
151.
Zurück zum Zitat Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, Gilb B, Kaufmann T, Borner C, Sleeman JP, Simon JC. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John’s wort that acts by induction of apoptosis. Oncogene. 2002;21:1242–50.PubMedCrossRef Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, Gilb B, Kaufmann T, Borner C, Sleeman JP, Simon JC. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John’s wort that acts by induction of apoptosis. Oncogene. 2002;21:1242–50.PubMedCrossRef
152.
Zurück zum Zitat Hostanska K, Reichling J, Bommer S, Weber M, Saller R. Hyperforin a constituent of St. John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur J Pharm Biopharm. 2003;56:121–32.PubMedCrossRef Hostanska K, Reichling J, Bommer S, Weber M, Saller R. Hyperforin a constituent of St. John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur J Pharm Biopharm. 2003;56:121–32.PubMedCrossRef
153.
Zurück zum Zitat Dona M, Dell’Aica I, Pezzato E, Sartor L, Calabrese F, Della Barbera M, Donella-Deana A, Appendino G, Borsarini A, Caniato R, Garbisa S. Hyperforin inhibits cancer invasion and metastasis. Cancer Res. 2004;64:6225–32.PubMedCrossRef Dona M, Dell’Aica I, Pezzato E, Sartor L, Calabrese F, Della Barbera M, Donella-Deana A, Appendino G, Borsarini A, Caniato R, Garbisa S. Hyperforin inhibits cancer invasion and metastasis. Cancer Res. 2004;64:6225–32.PubMedCrossRef
154.
Zurück zum Zitat Martínez-Poveda B, Quesada AR, Medina MA. Hyperforin, a bio-active compound of St. John’s wort, is a new inhibitor of angiogenesis targeting several key steps of the process. Inter J Cancer. 2005;17(5):775–80.CrossRef Martínez-Poveda B, Quesada AR, Medina MA. Hyperforin, a bio-active compound of St. John’s wort, is a new inhibitor of angiogenesis targeting several key steps of the process. Inter J Cancer. 2005;17(5):775–80.CrossRef
155.
Zurück zum Zitat Aggarwal BB, Bhardwaj A, Aggarwal RS, Steram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004;24:2783–840.PubMed Aggarwal BB, Bhardwaj A, Aggarwal RS, Steram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004;24:2783–840.PubMed
156.
Zurück zum Zitat Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Anti-angiogenic property of edible berries. Free Radic Res. 2002;36:1023–31.PubMedCrossRef Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Anti-angiogenic property of edible berries. Free Radic Res. 2002;36:1023–31.PubMedCrossRef
157.
Zurück zum Zitat Pozo-Guisado E, Merino JM, Mulero-Navarro S, Lorenzo-Benayas MJ, Centeno F, Alvarez-Barrientos A, Salguero PMF. Resveratrol-induced apoptosis in Mcf-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-κB. Int J Cancer. 2005;115:74–84.PubMedCrossRef Pozo-Guisado E, Merino JM, Mulero-Navarro S, Lorenzo-Benayas MJ, Centeno F, Alvarez-Barrientos A, Salguero PMF. Resveratrol-induced apoptosis in Mcf-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-κB. Int J Cancer. 2005;115:74–84.PubMedCrossRef
158.
Zurück zum Zitat Kiliańska ZM, Żołnierczyk J, Węgierska-Gądek J. Biological activity of poly (ADP-ribose) -1. Postep. Hig Med Dosw. 2010;64:344–63. Kiliańska ZM, Żołnierczyk J, Węgierska-Gądek J. Biological activity of poly (ADP-ribose) -1. Postep. Hig Med Dosw. 2010;64:344–63.
159.
Zurück zum Zitat Roy P, Kalra N, Prasad S, George J, Skuhla Y. Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways. Pharmaceut Res. 2009;26:221–17.CrossRef Roy P, Kalra N, Prasad S, George J, Skuhla Y. Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways. Pharmaceut Res. 2009;26:221–17.CrossRef
160.
Zurück zum Zitat Cao Y, Fu ZD, Wang F, Liu HY, Han R. Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants. J Asian Nat Prod Res. 2005;7:205–13.PubMedCrossRef Cao Y, Fu ZD, Wang F, Liu HY, Han R. Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants. J Asian Nat Prod Res. 2005;7:205–13.PubMedCrossRef
161.
Zurück zum Zitat Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001;171:11–6.PubMedCrossRef Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001;171:11–6.PubMedCrossRef
162.
Zurück zum Zitat Lin MT, Yen ML, Lin CY, Kuo ML. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of src dependent vascular endothelial cadherin tyrosine phosphorylation. Mol Pharmacol. 2003;64:1029–36.PubMedCrossRef Lin MT, Yen ML, Lin CY, Kuo ML. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of src dependent vascular endothelial cadherin tyrosine phosphorylation. Mol Pharmacol. 2003;64:1029–36.PubMedCrossRef
163.
Zurück zum Zitat Kanavi MR, Darjatmoko S, Wang S, Azari AA, Farnoodian M, Kenealey JD, van Ginkel PR, Albert DM, Sheibani N, Polans AS. The sustained delivery of resveratrol or a defined grape powder inhibits new blood vessel formation in a mouse model of choroidal neovascularization. Molecules. 2014;19(11):17578–603.PubMedPubMedCentralCrossRef Kanavi MR, Darjatmoko S, Wang S, Azari AA, Farnoodian M, Kenealey JD, van Ginkel PR, Albert DM, Sheibani N, Polans AS. The sustained delivery of resveratrol or a defined grape powder inhibits new blood vessel formation in a mouse model of choroidal neovascularization. Molecules. 2014;19(11):17578–603.PubMedPubMedCentralCrossRef
164.
Zurück zum Zitat Zhang H, He S, Spee C, Ishikawa K, Hinton DR. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by resveratrol and its relevance to choroidal neovascularization. Cytokine. 2001;76(2):549–52.CrossRef Zhang H, He S, Spee C, Ishikawa K, Hinton DR. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by resveratrol and its relevance to choroidal neovascularization. Cytokine. 2001;76(2):549–52.CrossRef
165.
Zurück zum Zitat Zhang X, Song Y, Wu Y, et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011;129:2502–11.PubMedCrossRef Zhang X, Song Y, Wu Y, et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011;129:2502–11.PubMedCrossRef
166.
Zurück zum Zitat Vitale DC, Piazza C, Melilli B, Drago F, Salomone S. Isoflavones: estrogenic activity, biological effect and bioavailability. Eur J Drug Metab Pharmacokinet. 2013;38(1):15–25.PubMedCrossRef Vitale DC, Piazza C, Melilli B, Drago F, Salomone S. Isoflavones: estrogenic activity, biological effect and bioavailability. Eur J Drug Metab Pharmacokinet. 2013;38(1):15–25.PubMedCrossRef
167.
169.
Zurück zum Zitat Giovannini C, Scazzocchio B, Varì R, Santangelo C, D’archivio M, Masella R. Apoptosis in cancer and atherosclerosis: polyphenol activities. Sanità Ann Ist Super Sanità. 2007;43:406–16.PubMed Giovannini C, Scazzocchio B, Varì R, Santangelo C, D’archivio M, Masella R. Apoptosis in cancer and atherosclerosis: polyphenol activities. Sanità Ann Ist Super Sanità. 2007;43:406–16.PubMed
170.
Zurück zum Zitat Huynh H, Nguyen TT, Chan E, Tran E. Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-α)- and epidermal growth factor (EGF) induced human PC-3 prostate cancer cell proliferation. Int J Oncol. 2003;23:821–9.PubMed Huynh H, Nguyen TT, Chan E, Tran E. Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-α)- and epidermal growth factor (EGF) induced human PC-3 prostate cancer cell proliferation. Int J Oncol. 2003;23:821–9.PubMed
171.
Zurück zum Zitat Tan WF, Lin LP, Li MH, Zhang YX, Dong JG, Xiao D, Din J. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol. 2003;459:255–62.PubMedCrossRef Tan WF, Lin LP, Li MH, Zhang YX, Dong JG, Xiao D, Din J. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol. 2003;459:255–62.PubMedCrossRef
172.
Zurück zum Zitat O’Leary KA, de Pascual–Tereasa S, Needs PW, Bao YP, O’Brien NM, Williamson G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat Res. 2004;551:245–54.PubMedCrossRef O’Leary KA, de Pascual–Tereasa S, Needs PW, Bao YP, O’Brien NM, Williamson G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat Res. 2004;551:245–54.PubMedCrossRef
173.
Zurück zum Zitat Dash R, Uddin MM, Hosen SM, Rahim ZB, Dinar AM, Kabir MS, Sultan RA, Islam A, Hossain MK. Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer. Bioinformat. 2015;11(12):543–9.CrossRef Dash R, Uddin MM, Hosen SM, Rahim ZB, Dinar AM, Kabir MS, Sultan RA, Islam A, Hossain MK. Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer. Bioinformat. 2015;11(12):543–9.CrossRef
174.
Zurück zum Zitat Ma ZS, Huynh TH, Ng CP, Do PT, Nguyen TH, Huynh H. Reduction of CWR22 prostate tumor xenograft growth by combined tamoxifen-quercetin treatment is associated with inhibition of angiogenesis and cellular proliferation. Int J Oncol. 2004;24:1297–304.PubMed Ma ZS, Huynh TH, Ng CP, Do PT, Nguyen TH, Huynh H. Reduction of CWR22 prostate tumor xenograft growth by combined tamoxifen-quercetin treatment is associated with inhibition of angiogenesis and cellular proliferation. Int J Oncol. 2004;24:1297–304.PubMed
175.
Zurück zum Zitat Mojzis J, Varinska L, Mojzisova G, Kostova I, Mirossay L. Anti-angiogenic effects of flavonoids and chalcones. Pharmacol Res. 2008;57(4):259–65.PubMedCrossRef Mojzis J, Varinska L, Mojzisova G, Kostova I, Mirossay L. Anti-angiogenic effects of flavonoids and chalcones. Pharmacol Res. 2008;57(4):259–65.PubMedCrossRef
176.
Zurück zum Zitat Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. PNAS. 2008;105:11105–9.PubMedPubMedCentralCrossRef Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. PNAS. 2008;105:11105–9.PubMedPubMedCentralCrossRef
177.
Zurück zum Zitat Rastogi T, Devesa S, Mangtani P, Mathew A, Cooper N, Kao R, Sinha R. Cancer incidence rates among south Asians in four geographic regions: India, Singapore, UK and US. Int J Epidemiol. 2007;37:147–60.PubMedCrossRef Rastogi T, Devesa S, Mangtani P, Mathew A, Cooper N, Kao R, Sinha R. Cancer incidence rates among south Asians in four geographic regions: India, Singapore, UK and US. Int J Epidemiol. 2007;37:147–60.PubMedCrossRef
178.
Zurück zum Zitat Mense SM, Hei TK, Ganju RK, Bhat HK. Phytoestrogens and breast cancer prevention: possible mechanisms of action. Environ Health Perspect. 2008;116:426–33.PubMedPubMedCentralCrossRef Mense SM, Hei TK, Ganju RK, Bhat HK. Phytoestrogens and breast cancer prevention: possible mechanisms of action. Environ Health Perspect. 2008;116:426–33.PubMedPubMedCentralCrossRef
179.
Zurück zum Zitat Gutierrez RMP. Flavonoids. In: Handbook of compounds with cytotoxic activity isolated from plants. Commack, NY: Nova Science Publishers Inc.; 2007. p. 158–65. Gutierrez RMP. Flavonoids. In: Handbook of compounds with cytotoxic activity isolated from plants. Commack, NY: Nova Science Publishers Inc.; 2007. p. 158–65.
180.
Zurück zum Zitat Sharma P, Kapoor S. Biopharmaceutical aspects of Brassica vegetables. J Pharm Phytochem. 2015;4(1):140–7. Sharma P, Kapoor S. Biopharmaceutical aspects of Brassica vegetables. J Pharm Phytochem. 2015;4(1):140–7.
181.
Zurück zum Zitat Teicher BA. Newer cytotoxic agents: attacking cancer broadly. Clin Cancer Res. 2008;14:1610–7.PubMedCrossRef Teicher BA. Newer cytotoxic agents: attacking cancer broadly. Clin Cancer Res. 2008;14:1610–7.PubMedCrossRef
182.
Zurück zum Zitat Katz L, Baltz RH. Natural product discovery: past, present, and future. J Ind Microbiol Biotechnol. 2016;43(2–3):155–76.PubMedCrossRef Katz L, Baltz RH. Natural product discovery: past, present, and future. J Ind Microbiol Biotechnol. 2016;43(2–3):155–76.PubMedCrossRef
183.
Zurück zum Zitat Vacca A, Iurlaro M, Ribatti D, Minischetti M, Nico B, Ria R, Pellegrino A, Dammacco F. Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood. 1997;94:4143–55. Vacca A, Iurlaro M, Ribatti D, Minischetti M, Nico B, Ria R, Pellegrino A, Dammacco F. Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood. 1997;94:4143–55.
184.
Zurück zum Zitat Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, Bohlen P, Kerbel RS. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest. 2000;105:R15–24.PubMedPubMedCentralCrossRef Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, Bohlen P, Kerbel RS. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest. 2000;105:R15–24.PubMedPubMedCentralCrossRef
185.
Zurück zum Zitat Klement G, Huang P, Mayer B, Green SK, Man S, Bohlen P, Hicklin D, Kerbel RS. Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin Cancer Res. 2002;8:221–32.PubMed Klement G, Huang P, Mayer B, Green SK, Man S, Bohlen P, Hicklin D, Kerbel RS. Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin Cancer Res. 2002;8:221–32.PubMed
186.
Zurück zum Zitat Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4:423–36.PubMedCrossRef Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4:423–36.PubMedCrossRef
187.
Zurück zum Zitat Stempac D, Seely D, Baruchel S. Metronomic dosing of chemotherapy: applications in pediatric oncology. Cancer Investig. 2006;24:432–43.CrossRef Stempac D, Seely D, Baruchel S. Metronomic dosing of chemotherapy: applications in pediatric oncology. Cancer Investig. 2006;24:432–43.CrossRef
188.
Zurück zum Zitat Verreault M, Strutt D, Masin D, Anantha M, Yung A, Kozlowski P, Waterhouse D, Bally MB, Yapp DT. Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine. BMC Cancer. 2011;11:124–42.PubMedPubMedCentralCrossRef Verreault M, Strutt D, Masin D, Anantha M, Yung A, Kozlowski P, Waterhouse D, Bally MB, Yapp DT. Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine. BMC Cancer. 2011;11:124–42.PubMedPubMedCentralCrossRef
189.
Zurück zum Zitat Avramis IA, Kwock R, Avramis VI. Taxotere and vincristine inhibit the secretion of the angiogenesis inducing vascular endothelial growth factor (VEGF) by wild-type and drug-resistant human leukemia T-cell lines. Anticancer Res. 2001;21(4):2281–6.PubMed Avramis IA, Kwock R, Avramis VI. Taxotere and vincristine inhibit the secretion of the angiogenesis inducing vascular endothelial growth factor (VEGF) by wild-type and drug-resistant human leukemia T-cell lines. Anticancer Res. 2001;21(4):2281–6.PubMed
190.
Zurück zum Zitat Mabeta P, Pepper MSA. Comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents. Angiogenesis. 2009;12:81–90.PubMedCrossRef Mabeta P, Pepper MSA. Comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents. Angiogenesis. 2009;12:81–90.PubMedCrossRef
191.
Zurück zum Zitat Pasquier E, Street J, Pouchy C, Carre M, Gifford AJ, Murray J, Norris MD, Trahair T, Andre N, Kavallaris M. Beta-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma. Br J Cancer. 2013;108:2485–94.PubMedPubMedCentralCrossRef Pasquier E, Street J, Pouchy C, Carre M, Gifford AJ, Murray J, Norris MD, Trahair T, Andre N, Kavallaris M. Beta-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma. Br J Cancer. 2013;108:2485–94.PubMedPubMedCentralCrossRef
192.
Zurück zum Zitat Grange C, Bussolati B, Bruno S, Fonsato V, Sapino A, Camussi G. Isolation and characterization of human breast tumor-derived endothelial cells. Oncol Rep. 2006;15:381–6.PubMed Grange C, Bussolati B, Bruno S, Fonsato V, Sapino A, Camussi G. Isolation and characterization of human breast tumor-derived endothelial cells. Oncol Rep. 2006;15:381–6.PubMed
193.
Zurück zum Zitat Xiong YQ, Sun HC, Zhang W, Zhu XD, Zhuang PY, Zhang JB, Wang L, Wu WZ, Qin LX, Tang ZY. Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells. Clin Cancer Res. 2009;15:4838–46.PubMedCrossRef Xiong YQ, Sun HC, Zhang W, Zhu XD, Zhuang PY, Zhang JB, Wang L, Wu WZ, Qin LX, Tang ZY. Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells. Clin Cancer Res. 2009;15:4838–46.PubMedCrossRef
194.
Zurück zum Zitat Polat U. The effects on metabolism of glucosinolates and their hydrolysis products. J Biol Environ Sci. 2010;4(10):39–42. Polat U. The effects on metabolism of glucosinolates and their hydrolysis products. J Biol Environ Sci. 2010;4(10):39–42.
195.
Zurück zum Zitat Chang HK, Shin MS, Yang HY, Lee JW, Kim YS, Lee MH, Kim J, Kim KH, Kim CJ. Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells. Biol Pharm Bul. 2006;29:1597–602.CrossRef Chang HK, Shin MS, Yang HY, Lee JW, Kim YS, Lee MH, Kim J, Kim KH, Kim CJ. Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells. Biol Pharm Bul. 2006;29:1597–602.CrossRef
196.
Zurück zum Zitat Milazzo S, Lejeune S, Ernst E. Laetrile for cancer: a systematic review of the clinical evidence. Suppor Care Cancer. 2007;15:583–95.CrossRef Milazzo S, Lejeune S, Ernst E. Laetrile for cancer: a systematic review of the clinical evidence. Suppor Care Cancer. 2007;15:583–95.CrossRef
197.
Zurück zum Zitat Hayes JD, Kelleher MO, Eggleston IM. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Clin Nutr. 2008;47:73–88.CrossRef Hayes JD, Kelleher MO, Eggleston IM. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Clin Nutr. 2008;47:73–88.CrossRef
198.
Zurück zum Zitat Zalega J, Szostak-Węgierek D. Nutrition in cancer prevention. Part I. Plant polyphenols, carotenoids, dietary fiber. ProblHig Epidemiol. 2013;94:41–9. Zalega J, Szostak-Węgierek D. Nutrition in cancer prevention. Part I. Plant polyphenols, carotenoids, dietary fiber. ProblHig Epidemiol. 2013;94:41–9.
199.
Zurück zum Zitat Kusznierewicz B., Piasek A., Lewandowska J., Śmiechowska A., Bartoszek A., Anti-carcinogenic properties of white cabbage. Żywność Nauka Technologia Jakość 2007; 6: 20–23. Kusznierewicz B., Piasek A., Lewandowska J., Śmiechowska A., Bartoszek A., Anti-carcinogenic properties of white cabbage. Żywność Nauka Technologia Jakość 2007; 6: 20–23.
200.
Zurück zum Zitat Traka M, Mithen R. Glucosinolates, isothiocyanates and human health. Phytochem Rev. 2009;8:269–82.CrossRef Traka M, Mithen R. Glucosinolates, isothiocyanates and human health. Phytochem Rev. 2009;8:269–82.CrossRef
201.
Zurück zum Zitat Casero RA, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov. 2007;6(5):373–90.PubMedCrossRef Casero RA, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov. 2007;6(5):373–90.PubMedCrossRef
202.
Zurück zum Zitat Zdrojewicz Z, Lachowski M. The importance of putrescine in the human body. Postepy Hig Med Dosw. 2014;68:393–403.CrossRef Zdrojewicz Z, Lachowski M. The importance of putrescine in the human body. Postepy Hig Med Dosw. 2014;68:393–403.CrossRef
203.
Zurück zum Zitat Kucharzewska P, Welch JE, Svensson KJ, Belting M. The polyamines regulate endothelial cell survival during hypoxic stress through PI3K/AKT and MCL-1. Biochem Bioph Res. 2009;380(2):413–8.CrossRef Kucharzewska P, Welch JE, Svensson KJ, Belting M. The polyamines regulate endothelial cell survival during hypoxic stress through PI3K/AKT and MCL-1. Biochem Bioph Res. 2009;380(2):413–8.CrossRef
204.
Zurück zum Zitat Koomoa DLT, Geerts D, Lange I, Koster J, Pegg AE, Feith DJ, Bachmann AS. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Int J Oncol. 2013;42:1219–28.PubMedPubMedCentral Koomoa DLT, Geerts D, Lange I, Koster J, Pegg AE, Feith DJ, Bachmann AS. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Int J Oncol. 2013;42:1219–28.PubMedPubMedCentral
205.
Zurück zum Zitat Jabłońska-Trypuć A, Czerpak R. The role of connective tissue growth factor (CTGF) in fibroproliferative processes and tissues fibrosis. Postepy Biol Komorki. 2009;36:135–54. Jabłońska-Trypuć A, Czerpak R. The role of connective tissue growth factor (CTGF) in fibroproliferative processes and tissues fibrosis. Postepy Biol Komorki. 2009;36:135–54.
206.
Zurück zum Zitat Minorsky PV. The hot and the classic. Plant Physiol. 2000;132:1135–6.CrossRef Minorsky PV. The hot and the classic. Plant Physiol. 2000;132:1135–6.CrossRef
207.
Zurück zum Zitat Ishii Y, Hori Y, Sakai S, Honma Y. Control of diferentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant rediferentiation-inducing hormones. Cell Growth Differ. 2002;13:19–26.PubMed Ishii Y, Hori Y, Sakai S, Honma Y. Control of diferentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant rediferentiation-inducing hormones. Cell Growth Differ. 2002;13:19–26.PubMed
208.
Zurück zum Zitat Kunikowska A, Byczkowska A, Doniak M, Kaźmierczak A. Cytokinins resume: their signaling and role in programmed cell death in plants. Plant Cell Rep. 2013;32:771–80.PubMedPubMedCentralCrossRef Kunikowska A, Byczkowska A, Doniak M, Kaźmierczak A. Cytokinins resume: their signaling and role in programmed cell death in plants. Plant Cell Rep. 2013;32:771–80.PubMedPubMedCentralCrossRef
209.
Zurück zum Zitat Coltella N, Valsecchi R, Ponente M, Ponzoni M, Bernardi R. Synergistic leukemia eradication by combined treatment with retinoic acid and HIF inhibition by EZN-2208 (PEG-SN38) in preclinical models of PML-RARα and PLZF-RARα-driven leukemia. Clin Cancer Res. 2015;21(16):3685–94.PubMedCrossRef Coltella N, Valsecchi R, Ponente M, Ponzoni M, Bernardi R. Synergistic leukemia eradication by combined treatment with retinoic acid and HIF inhibition by EZN-2208 (PEG-SN38) in preclinical models of PML-RARα and PLZF-RARα-driven leukemia. Clin Cancer Res. 2015;21(16):3685–94.PubMedCrossRef
210.
Zurück zum Zitat Liang C, Guo S, Yang L. Effects of all-trans retinoic acid on VEGF and HIF-1α expression in glioma cells under normoxia and hypoxia and its anti-angiogenic effect in an intracerebral glioma model. Mol Med Rep. 2014;10(5):2713–9.PubMed Liang C, Guo S, Yang L. Effects of all-trans retinoic acid on VEGF and HIF-1α expression in glioma cells under normoxia and hypoxia and its anti-angiogenic effect in an intracerebral glioma model. Mol Med Rep. 2014;10(5):2713–9.PubMed
211.
Zurück zum Zitat Aditya NP et al. Antiangiogenic effect of combined treatment with curcumin and genistein on human prostate cancer cell line. J Funct Foods. 2014;8:204–13.CrossRef Aditya NP et al. Antiangiogenic effect of combined treatment with curcumin and genistein on human prostate cancer cell line. J Funct Foods. 2014;8:204–13.CrossRef
212.
Zurück zum Zitat Yu X et al. Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation. Med Oncol. 2012;29(1):349–57.PubMedCrossRef Yu X et al. Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation. Med Oncol. 2012;29(1):349–57.PubMedCrossRef
213.
Zurück zum Zitat Mirzoeva S, Franzen CA, Pelling JC. Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3-and Src-dependent mechanism. Mol Carcinog. 2014;53(8):598–609.PubMed Mirzoeva S, Franzen CA, Pelling JC. Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3-and Src-dependent mechanism. Mol Carcinog. 2014;53(8):598–609.PubMed
214.
Zurück zum Zitat Silvan S, Manoharan S. Apigenin prevents deregulation in the expression pattern of cell-proliferative, apoptotic, inflammatory and angiogenic markers during 7, 12-dimethylbenz [a] anthracene-induced hamster buccal pouch carcinogenesis. Arch Oral Biol. 2013;58(1):94–101.PubMedCrossRef Silvan S, Manoharan S. Apigenin prevents deregulation in the expression pattern of cell-proliferative, apoptotic, inflammatory and angiogenic markers during 7, 12-dimethylbenz [a] anthracene-induced hamster buccal pouch carcinogenesis. Arch Oral Biol. 2013;58(1):94–101.PubMedCrossRef
215.
Zurück zum Zitat Kumar S, Raina K, Agarwal R. Chemopreventive and anticancer efficacy of silibinin against colorectal cancer, Multi-Targeted Approach to Treatment of Cancer. Berlin Heidelberg New York: Springer; 2015. p. 339–50. Kumar S, Raina K, Agarwal R. Chemopreventive and anticancer efficacy of silibinin against colorectal cancer, Multi-Targeted Approach to Treatment of Cancer. Berlin Heidelberg New York: Springer; 2015. p. 339–50.
216.
Zurück zum Zitat Yang SH, Lin JK, Chen WS, Chiu JH. Yang. Anti-angiogenic effects of silymarin on colon cancer LoVo cell line. J Surg Res. 2003;113(1):133–4l.PubMedCrossRef Yang SH, Lin JK, Chen WS, Chiu JH. Yang. Anti-angiogenic effects of silymarin on colon cancer LoVo cell line. J Surg Res. 2003;113(1):133–4l.PubMedCrossRef
217.
Zurück zum Zitat Kim KK et al. Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells. Int J Oncol. 2012;40(1):227–35.PubMed Kim KK et al. Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells. Int J Oncol. 2012;40(1):227–35.PubMed
218.
Zurück zum Zitat Wang M-L et al. Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages. Food Chem. 2012;134(2):811–20.PubMedCrossRef Wang M-L et al. Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages. Food Chem. 2012;134(2):811–20.PubMedCrossRef
219.
Zurück zum Zitat Kunimasa K et al. Antiangiogenic effects of indole-3-carbinol and 3,3′-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC. J Nutr. 2010;140(1):1–6.PubMedCrossRef Kunimasa K et al. Antiangiogenic effects of indole-3-carbinol and 3,3′-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC. J Nutr. 2010;140(1):1–6.PubMedCrossRef
220.
Zurück zum Zitat Mohan R et al. Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis. 2004;7(2):115–22.PubMedCrossRef Mohan R et al. Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis. 2004;7(2):115–22.PubMedCrossRef
221.
Zurück zum Zitat Hussain S et al. Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis. Angiogenesis. 2008;11(3):245–56.PubMedCrossRef Hussain S et al. Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis. Angiogenesis. 2008;11(3):245–56.PubMedCrossRef
222.
Zurück zum Zitat Nathan P, Zweifel M, Padhani AR, et al. Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer. Clin Cancer Res. 2012;18(12):3428–39.PubMedCrossRef Nathan P, Zweifel M, Padhani AR, et al. Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer. Clin Cancer Res. 2012;18(12):3428–39.PubMedCrossRef
224.
Zurück zum Zitat Zweifel M, Jayson GC, Reed NS, Osborne R, Hassan B, Ledermann J, Shreeves G, Poupard L, Lu SP, Balkissoon J, Chaplin DJ, Rustin GJ. Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer. Ann Oncol. 2011;22:2036–41.PubMedCrossRef Zweifel M, Jayson GC, Reed NS, Osborne R, Hassan B, Ledermann J, Shreeves G, Poupard L, Lu SP, Balkissoon J, Chaplin DJ, Rustin GJ. Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer. Ann Oncol. 2011;22:2036–41.PubMedCrossRef
225.
Zurück zum Zitat Granata R, Locati L, Licitra L. Therapeutic strategies in the management of patients with metastatic anaplastic thyroid cancer: review of the current literature. Curr Opin Oncol. 2013;25:224–8.PubMed Granata R, Locati L, Licitra L. Therapeutic strategies in the management of patients with metastatic anaplastic thyroid cancer: review of the current literature. Curr Opin Oncol. 2013;25:224–8.PubMed
226.
Zurück zum Zitat Ibrahim MA, Do DV, Sepah YJ, Shah SM, Van Anden E, Hafiz G, Donahue JK, Rivers R, Balkissoon J, Handa JT, Campochiaro PA, Nguyen QD. Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate. BMC Pharmacol Toxicol. 2013;14:7. doi:10.1186/2050-6511-14-7.PubMedPubMedCentralCrossRef Ibrahim MA, Do DV, Sepah YJ, Shah SM, Van Anden E, Hafiz G, Donahue JK, Rivers R, Balkissoon J, Handa JT, Campochiaro PA, Nguyen QD. Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate. BMC Pharmacol Toxicol. 2013;14:7. doi:10.​1186/​2050-6511-14-7.PubMedPubMedCentralCrossRef
228.
Zurück zum Zitat LoRusso PM, Boerner SA, Hunsberger S. Clinical development of vascular disrupting agents: what lessons can we learn from ASA404? J Clin Oncol. 2011;29(22):2952–5.PubMedCrossRef LoRusso PM, Boerner SA, Hunsberger S. Clinical development of vascular disrupting agents: what lessons can we learn from ASA404? J Clin Oncol. 2011;29(22):2952–5.PubMedCrossRef
230.
Zurück zum Zitat Head M, Jameson MB. The development of the tumor vascular-disrupting agent ASA404 (vadimezan, DMXAA): current status and future opportunities. Expert Opin Investig Drugs. 2010;19(2):295–304.PubMedCrossRef Head M, Jameson MB. The development of the tumor vascular-disrupting agent ASA404 (vadimezan, DMXAA): current status and future opportunities. Expert Opin Investig Drugs. 2010;19(2):295–304.PubMedCrossRef
231.
Zurück zum Zitat Lara, P. N., Douillard, J. Y., Nakagawa, K., Von Pawel, J., McKeage, M. J., et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol. 2011;JCO-2011. Lara, P. N., Douillard, J. Y., Nakagawa, K., Von Pawel, J., McKeage, M. J., et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol. 2011;JCO-2011.
232.
233.
Zurück zum Zitat Lorusso PM, Boerner SA, Hunsberger S. Clinical development of vascular disrupting agents: what lessons can we learn from ASA404? J Clin Oncol. 2011;29(22):2951–2.CrossRef Lorusso PM, Boerner SA, Hunsberger S. Clinical development of vascular disrupting agents: what lessons can we learn from ASA404? J Clin Oncol. 2011;29(22):2951–2.CrossRef
235.
Zurück zum Zitat Tsimberidou AA-MA, Akerley W, Schabel MC, et al. Phase I clinical trial of MPC-6827 (Azixa), a microtubule destabilizing agent, in patients with advanced cancer. Mol Cancer Ther. 2010;6827(12):3410–9.CrossRef Tsimberidou AA-MA, Akerley W, Schabel MC, et al. Phase I clinical trial of MPC-6827 (Azixa), a microtubule destabilizing agent, in patients with advanced cancer. Mol Cancer Ther. 2010;6827(12):3410–9.CrossRef
236.
Zurück zum Zitat Patterson DM, Zweifel M, Middleton MR, et al. Phase I clinical and pharmacokinetic evaluation of the vascular disrupting agent OXi4503 in patients with advanced solid tumors. Clin Cancer Res. 2012;18(5):1415–25.PubMedCrossRef Patterson DM, Zweifel M, Middleton MR, et al. Phase I clinical and pharmacokinetic evaluation of the vascular disrupting agent OXi4503 in patients with advanced solid tumors. Clin Cancer Res. 2012;18(5):1415–25.PubMedCrossRef
237.
Zurück zum Zitat Burns CJ, Fantino E, Powell AK, et al. The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo. J Pharmacol Exp Ther. 2011;339(3):799–806.PubMedCrossRef Burns CJ, Fantino E, Powell AK, et al. The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo. J Pharmacol Exp Ther. 2011;339(3):799–806.PubMedCrossRef
238.
Zurück zum Zitat Burge M, Francesconi AB, Kotasek D, et al. Phase I, pharmacokinetic and pharmacodynamic evaluation of CYT997, an orally-bioavailable cytotoxic and vascular disrupting agent. Investig New Drugs. 2013;31(1):126–35.CrossRef Burge M, Francesconi AB, Kotasek D, et al. Phase I, pharmacokinetic and pharmacodynamic evaluation of CYT997, an orally-bioavailable cytotoxic and vascular disrupting agent. Investig New Drugs. 2013;31(1):126–35.CrossRef
Metadaten
Titel
Natural products against cancer angiogenesis
verfasst von
El Bairi Khalid
EL-Meghawry EL-Kenawy Ayman
Heshu Rahman
Guaadaoui Abdelkarim
Agnieszka Najda
Publikationsdatum
20.09.2016
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 11/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-5364-8

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