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Neurotherapeutics

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01.07.2014 | Review

Deep Brain Stimulation for the Treatment of Epilepsy: Circuits, Targets, and Trials

verfasst von: Nealen G. Laxpati, Willard S. Kasoff, Robert E. Gross

Erschienen in: Neurotherapeutics | Ausgabe 3/2014

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Abstract

Deep brain stimulation (DBS) has proven remarkably safe and effective in the treatment of movement disorders. As a result, it is being increasingly applied to a range of neurologic and psychiatric disorders, including medically refractory epilepsy. This review will examine the use of DBS in epilepsy, including known targets, mechanisms of neuromodulation and seizure control, published clinical evidence, and novel technologies. Cortical and deep neuromodulation for epilepsy has a long experimental history, but only recently have better understanding of epileptogenic networks, precise stereotactic techniques, and rigorous trial design combined to improve the quality of available evidence and make DBS a viable treatment option. Nonetheless, underlying mechanisms, anatomical targets, and stimulation parameters remain areas of active investigation.

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Titel: Deep Brain Stimulation for the Treatment of Epilepsy: Circuits, Targets, and Trials
verfasst von: Nealen G. Laxpati
Willard S. Kasoff
Robert E. Gross
Publikationsdatum: 01.07.2014
Verlag: Springer US
Erschienen in: Neurotherapeutics / Ausgabe 3/2014
Print ISSN: 1933-7213
Elektronische ISSN: 1878-7479
DOI: https://doi.org/10.1007/s13311-014-0279-9

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