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Neurotherapeutics
Erschienen in: Neurotherapeutics 4/2016

01.10.2016 | Review

Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?

verfasst von: Nikunj Satani, Sean I. Savitz

Erschienen in: Neurotherapeutics | Ausgabe 4/2016

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Abstract

Inflammation within the brain and in peripheral tissues contributes to brain injury following ischemic stroke. Therapeutic modulation of the inflammatory response has been actively pursued as a novel stroke treatment approach for decades, without success. In recent years, extensive studies support the high potential for cell-based therapies to become a new treatment modality for stroke and other neurological disorders. In this review, we explore different types of cellular therapies and discuss how they modulate central and peripheral inflammatory processes after stroke. Apart from identifying potential targets for cell therapy, we also discuss paracrine and immunomodulatory mechanisms of cell therapy.
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Metadaten
Titel
Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?
verfasst von
Nikunj Satani
Sean I. Savitz
Publikationsdatum
01.10.2016
Verlag
Springer US
Erschienen in
Neurotherapeutics / Ausgabe 4/2016
Print ISSN: 1933-7213
Elektronische ISSN: 1878-7479
DOI
https://doi.org/10.1007/s13311-016-0468-9

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