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Erschienen in: Journal of NeuroVirology 2/2011

01.04.2011

A comparison of performance-based measures of function in HIV-associated neurocognitive disorders

verfasst von: Nishiena S. Gandhi, Richard L. Skolasky, Katherine B. Peters, Richard T. Moxley IV, Jason Creighton, Heidi Vornbrock Roosa, Ola A. Selnes, Justin McArthur, Ned Sacktor

Erschienen in: Journal of NeuroVirology | Ausgabe 2/2011

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Abstract

The objectives of this study are to compare the results of newer performance-based functional assessments in the study of HIV-associated neurocognitive disorders (HAND) and to correlate these functional assessments with specific levels of severity of HAND. One hundred fourteen HIV+ subjects in an existing cohort were evaluated with a medical history, neurological exam, neuropsychological test battery as well as subjective and novel objective measures of functional abilities. Self-reported measures of functional performance included the Karnofsky Performance Scale, a questionnaire for instrumental activities of daily living, and a questionnaire for physical quality of life measures. The newer objective functional performance assessments included the Columbia Medication Management and the San Diego Finances tests. These newer performance-based measures of function were assessed for their ability to predict level of HAND. The two objective measures of functional performance, The Columbia Medication Management Scale and the San Diego Finances Test, were both associated with levels of severity of HAND. The Karnofsky Performance Scale and the questionnaires for role and physical quality of life were subjective measures that were also associated with specific levels of HAND. Newer measures of functional performance can be used to objectively evaluate functional impairment in HAND and validate different levels of HAND.
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Metadaten
Titel
A comparison of performance-based measures of function in HIV-associated neurocognitive disorders
verfasst von
Nishiena S. Gandhi
Richard L. Skolasky
Katherine B. Peters
Richard T. Moxley IV
Jason Creighton
Heidi Vornbrock Roosa
Ola A. Selnes
Justin McArthur
Ned Sacktor
Publikationsdatum
01.04.2011
Verlag
Springer US
Erschienen in
Journal of NeuroVirology / Ausgabe 2/2011
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-011-0023-8

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