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01.02.2012 | Short Communication

Altered prefronto-striato-parietal network response to mental rotation in HIV

verfasst von: Brian C. Schweinsburg, J. Cobb Scott, Alecia Dager Schweinsburg, Joanna Jacobus, Rebecca J. Theilmann, Larry R. Frank, Erica Weber, Igor Grant, Steven Paul Woods, and the HIV Neurobehavioral Research Center (HNRC) Group

Erschienen in: Journal of NeuroVirology | Ausgabe 1/2012

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Abstract

The present study used functional magnetic resonance imaging to examine the neural substrates of mental rotation in 11 individuals with HIV infection and 13 demographically similar HIV seronegative volunteers. Individuals with HIV showed increased brain response to mental rotation in prefrontal and posterior parietal cortices, striatum, and thalamus, with significant HIV by angle interactions emerging in the prefrontal cortex and caudate. Results indicate that HIV infection is associated with altered brain response to mental rotation in fronto-striato-parietal pathways, which may reflect compensatory strategies, recruitment of additional brain regions, and/or increased neuroenergetic demands during mental rotation needed to offset underlying HIV-associated neural injury.

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Titel: Altered prefronto-striato-parietal network response to mental rotation in HIV
verfasst von: Brian C. Schweinsburg
J. Cobb Scott
Alecia Dager Schweinsburg
Joanna Jacobus
Rebecca J. Theilmann
Larry R. Frank
Erica Weber
Igor Grant
Steven Paul Woods
and the HIV Neurobehavioral Research Center (HNRC) Group
Publikationsdatum: 01.02.2012
Verlag: Springer US
Erschienen in: Journal of NeuroVirology / Ausgabe 1/2012
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-011-0072-z

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Altered prefronto-striato-parietal network response to mental rotation in HIV

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