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01.12.2013

Real-world impact of neurocognitive deficits in acute and early HIV infection

verfasst von: Katie L. Doyle, Erin E. Morgan, Sheldon Morris, Davey M. Smith, Susan Little, Jennifer E. Iudicello, Kaitlin Blackstone, David J. Moore, Igor Grant, Scott L. Letendre, Steven Paul Woods, The Translational Methamphetamine AIDS Research Center (TMARC) Group

Erschienen in: Journal of NeuroVirology | Ausgabe 6/2013

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Abstract

The acute and early period of HIV-1 infection (AEH) is characterized by neuroinflammatory and immunopathogenic processes that can alter the integrity of neural systems and neurocognitive functions. However, the extent to which central nervous system changes in AEH confer increased risk of real-world functioning (RWF) problems is not known. In the present study, 34 individuals with AEH and 39 seronegative comparison participants completed standardized neuromedical, psychiatric, and neurocognitive research evaluations, alongside a comprehensive assessment of RWF that included cognitive symptoms in daily life, basic and instrumental activities of daily living, clinician-rated global functioning, and employment. Results showed that AEH was associated with a significantly increased risk of dependence in RWF, which was particularly elevated among AEH persons with global neurocognitive impairment (NCI). Among those with AEH, NCI (i.e., deficits in learning and information processing speed), mood disorders (i.e., Bipolar Disorder), and substance dependence (e.g., methamphetamine dependence) were all independently predictive of RWF dependence. Findings suggest that neurocognitively impaired individuals with AEH are at notably elevated risk of clinically significant challenges in normal daily functioning. Screening for neurocognitive, mood, and substance use disorders in AEH may facilitate identification of individuals at high risk of functional dependence who may benefit from psychological and medical strategies to manage their neuropsychiatric conditions.

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Titel: Real-world impact of neurocognitive deficits in acute and early HIV infection
verfasst von: Katie L. Doyle
Erin E. Morgan
Sheldon Morris
Davey M. Smith
Susan Little
Jennifer E. Iudicello
Kaitlin Blackstone
David J. Moore
Igor Grant
Scott L. Letendre
Steven Paul Woods
The Translational Methamphetamine AIDS Research Center (TMARC) Group
Publikationsdatum: 01.12.2013
Verlag: Springer US
Erschienen in: Journal of NeuroVirology / Ausgabe 6/2013
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-013-0218-2

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