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01.04.2016

Age exacerbates HIV-associated white matter abnormalities

verfasst von: Talia R. Seider, Assawin Gongvatana, Adam J. Woods, Huaihou Chen, Eric C. Porges, Tiffany Cummings, Stephen Correia, Karen Tashima, Ronald A. Cohen

Erschienen in: Journal of NeuroVirology | Ausgabe 2/2016

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Abstract

Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the combined effects of age and HIV serostatus on WMH and DTI measures, as well as the relationships between these white matter measures, in 88 HIV seropositive (HIV+) and 49 seronegative (HIV−) individuals aged 23–79 years. A whole-brain volumetric measure of WMH was quantified from FLAIR images using a semi-automated process, while fractional anisotropy (FA) was calculated for 15 regions of a whole-brain white matter skeleton generated using tract-based spatial statistics (TBSS). An age by HIV interaction was found indicating a significant association between WMH and older age in HIV+ participants only. Similarly, significant age by HIV interactions were found indicating stronger associations between older age and decreased FA in the posterior limbs of the internal capsules, cerebral peduncles, and anterior corona radiata in HIV+ vs. HIV− participants. The interactive effects of HIV and age were stronger with respect to whole-brain WMH than for any of the FA measures. Among HIV+ participants, greater WMH and lower anterior corona radiata FA were associated with active hepatitis C virus infection, a history of AIDS, and higher current CD4 cell count. Results indicate that age exacerbates HIV-associated abnormalities of whole-brain WMH and fronto-subcortical white matter integrity.

Abe O, Aoki S, Hayashi N, Yamada H, Kunimatsu A, Mori H, Yoshikawa T, Okubo T, Ohtomo K (2002) Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis. Neurobiol Aging 23(3):433–441. doi:10.1016/S0197-4580(01)00318-9 CrossRefPubMed

Aine CJ, Sanfratello L, Adair JC, Knoefel JE, Qualls C, Lundy SL, Caprihan A, Stone D, Stephen JM (2014) Characterization of a normal control group: are they healthy? Neuroimage 84:796–809. doi:10.1016/j.neuroimage.2013.09.025 CrossRefPubMedPubMedCentral

Alexander DC, Pierpaoli C, Basser PJ, Gee JC (2001) Spatial transformations of diffusion tensor magnetic resonance images. IEEE Trans Med Imaging 20(11):1131–1139. doi:10.1109/42.963816 CrossRefPubMed

Ances BM, Ortega M, Vaida F, Heaps J, Paul R (2012) Independent effects of HIV, aging, and HAART on brain volumetric measures. J Acquir Immune Defic Syndr 59(5):469–477. doi:10.1097/QAI.0b013e318249db17 CrossRefPubMedPubMedCentral

Appel J, Potter E, Bhatia N, Shen Q, Zhao W, Greig MT, Raj A, Barker WW, Potter H, Schofield E, Wu Y, Loewenstein DA, Duara R (2009) Association of white matter hyperintensity measurements on brain mr imaging with cognitive status, medial temporal atrophy, and cardiovascular risk factors. AJNR Am J Neuroradiol 30(10):1870–1876. doi:10.3174/ajnr.A1693 CrossRefPubMed

Ardekani S, Kumar A, Bartzokis G, Sinha U (2007) Exploratory voxel-based analysis of diffusion indices and hemispheric asymmetry in normal aging. Magn Reson Imaging 25(2):154–167. doi:10.1016/j.mri.2006.09.045 CrossRefPubMed

Aylward EH, Henderer B, Jea MC (1993) Reduced basal ganglia volume in HIV-1 associated dementia: results from quantitative neuroimaging. Neurology 43:2099–2104. doi:10.1212/WNL.43.10.2099 CrossRefPubMed

Basser PJ, Jones DK (2002) Diffusion-tensor MRI: theory, experimental design and data analysis—a technical review. NMR Biomed 15(7–8):456–467. doi:10.1002/nbm.783 CrossRefPubMed

Becker JT, Lopez OL, Dew MA, Aizenstein HJ (2004) Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS 18(Suppl 1):S11–18CrossRefPubMed

Becker JT, Maruca V, Kingsley LA, Sanders JM, Alger JR, Barker PB, Goodkin K, Martin E, Miller EN, Ragin A, Sacktor N, Selnes O, Multicenter ACS (2012) Factors affecting brain structure in men with HIV disease in the post-HAART era. Neuroradiology 54(2):113–121. doi:10.1007/s00234-011-0854-2 CrossRefPubMedPubMedCentral

Bendlin BB, Fitzgerald ME, Ries ML, Xu G, Kastman EK, Thiel BW, Rowley HA, Lazar M, Alexander AL, Johnson SC (2010) White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three. Dev Neuropsychol 35(3):257–277. doi:10.1080/87565641003696775 CrossRefPubMedPubMedCentral

Bhatia R, Ryscavage P, Taiwo B (2012) Accelerated aging and human immunodeficiency virus infection: emerging challenges of growing older in the era of successful antiretroviral therapy. J Neurovirol 18(4):247–255. doi:10.1007/s13365-011-0073-y CrossRefPubMed

Bradley W, Waluch V, Brant-Zawadzki M, Vadley R, Wycoff R (1984) Patchy periventricular white matter lesions in the elderly: a common observation during NMR imaging. Noninvasive Med Imaging 1:35–41

Brickman AM, Zimmerman ME, Paul RH, Grieve SM, Tate DF, Cohen RA, Williams LM, Clark CR, Gordon E (2006) Regional white matter and neuropsychological functioning across the adult lifespan. Biol Psychiatry 60(5):444–453. doi:10.1016/j.biopsych.2006.01.011 CrossRefPubMed

Chang L, Holt JL, Yakupov R, Jiang CS, Ernst T (2013) Lower cognitive reserve in the aging human immunodeficiency virus-infected brain. Neurobiol Aging 34(4):1240–1253. doi:10.1016/j.neurobiolaging.2012.10.012 CrossRefPubMedPubMedCentral

Cohen RA, Boland R, Paul R, Tashima KT, Schoenbaum EE, Celentano DD, Schuman P, Smith DK, Carpenter CC (2001) Neurocognitive performance enhanced by highly active antiretroviral therapy in HIV-infected women. AIDS 15(3):341–345CrossRefPubMed

Cohen RA, Seider TR, Navia B (2015) HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease? Alzheimers Res Ther 7(1):37. doi:10.1186/s13195-015-0123-4 CrossRefPubMedPubMedCentral

Cox RW (1996) Afni: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29(3):162–173. doi:10.1006/cbmr.1996.0014 CrossRefPubMed

Detels R, Munoz A, McFarlane G, Kingsley LA, Margolick JB, Giorgi J, Schrager LK, Phair JP (1998) Effectiveness of potent antiretroviral therapy on time to aids and death in men with known HIV infection duration. Multicenter aids cohort study investigators. JAMA 280(17):1497–1503. doi:10.1001/jama.280.17.1497 CrossRefPubMed

Devlin KN, Gongvatana A, Clark US, Chasman JD, Westbrook ML, Tashima KT, Navia B, Cohen RA (2012) Neurocognitive effects of HIV, hepatitis C, and substance use history. J Int Neuropsychol Soc 18(1):68–78. doi:10.1017/S1355617711001408

Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, Huebner RE, Janoff EN, Justice AC, Kuritzkes D, Nayfield SG, Plaeger SF, Schmader KE, Ashworth JR, Campanelli C, Clayton CP, Rada B, Woolard NF, High KP (2008) Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis 47(4):542–553. doi:10.1086/590150 CrossRefPubMedPubMedCentral

Ernst T, Chang L (2004) Effect of aging on brain metabolism in antiretroviral-naive HIV patients. AIDS 18(Suppl 1):S61–67CrossRefPubMed

Ernst T, Itti E, Itti L, Chang L (2000) Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: a coregistered (1)H MRS and SPECT study. J Magn Reson Imaging 12(6):859–865CrossRefPubMed

Fennema-Notestine C, Ellis RJ, Archibald SL, Jernigan TL, Letendre SL, Notestine RJ, Taylor MJ, Theilmann RJ, Julaton MD, Croteau DJ, Wolfson T, Heaton RK, Gamst AC, Franklin DR Jr, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I, Group C (2013) Increases in brain white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV infection. J Neurovirol 19(4):393–401. doi:10.1007/s13365-013-0185-7 CrossRefPubMedPubMedCentral

Filippi C, Ulug A, Ryan E, Ferrando S, Van Gorp W (2001) Diffusion tensor imaging of patients with HIV and normal-appearing white matter on mr images of the brain. AJNR Am J Neuroradiol 22(2):277–283PubMed

Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman DD, Siliciano RF (1997) Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278(5341):1295–1300CrossRefPubMed

Fischl B (2012) Freesurfer. Neuroimage 62(2):774–781. doi:10.1016/j.neuroimage.2012.01.021 CrossRefPubMedPubMedCentral

Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HB (2000) Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet 356(9230):628–634. doi:10.1016/S0140-6736(00)02604-0 CrossRefPubMed

Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14(1 Pt 1):21–36. doi:10.1006/nimg.2001.0786 CrossRefPubMed

Greve DN, Fischl B (2009) Accurate and robust brain image alignment using boundary-based registration. Neuroimage 48(1):63–72. doi:10.1016/j.neuroimage.2009.06.060 CrossRefPubMedPubMedCentral

Grieve SM, Williams LM, Paul RH, Clark CR, Gordon E (2007) Cognitive aging, executive function, and fractional anisotropy: a diffusion tensor MR imaging study. AJNR Am J Neuroradiol 28(2):226–235PubMed

Grueter BE, Schulz UG (2012) Age-related cerebral white matter disease (leukoaraiosis): a review. Postgrad Med J 88(1036):79–87. doi:10.1136/postgradmedj-2011-130307 CrossRefPubMed

Head D, Buckner RL, Shimony JS, Williams LE, Akbudak E, Conturo TE, McAvoy M, Morris JC, Snyder AZ (2004) Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging. Cereb Cortex 14(4):410–423. doi:10.1093/cercor/bhh003 CrossRefPubMed

Hopkins RO, Beck CJ, Burnett DL, Weaver LK, Victoroff J, Bigler ED (2006) Prevalence of white matter hyperintensities in a young healthy population. J Neuroimaging 16(3):243–251. doi:10.1111/j.1552-6569.2006.00047.x CrossRefPubMed

Jenkinson M, Smith S (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5(2):143–156. doi:10.1016/S1361-8415(01)00036-6 CrossRefPubMed

Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17(2):825–841. doi:10.1006/nimg.2002.1132 CrossRefPubMed

Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM (2012) Fsl. Neuroimage 62(2):782–790. doi:10.1016/j.neuroimage.2011.09.015 CrossRefPubMed

Jernigan TL, Archibald SL, Fennema-Notestine C, Taylor MJ, Theilmann RJ, Julaton MD, Notestine RJ, Wolfson T, Letendre SL, Ellis RJ, Heaton RK, Gamst AC, Franklin DR Jr, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I, Group C (2011) Clinical factors related to brain structure in HIV: the CHARTER study. J Neurovirol 17(3):248–257. doi:10.1007/s13365-011-0032-7 CrossRefPubMedPubMedCentral

Little TD, Bovaird JA, Widaman KF (2006) On the merits of orthogonalizing powered and product terms: implications for modeling interactions among latent variables. Struct Equ Model 13(4):497–519. doi:10.1207/s15328007sem1304_1 CrossRef

Mack K, Ory M (2003) Aids and older Americans at the end of the twentieth century. J Acquir Immune Defic Syndr 33(2):568–572

Maillard P, Carmichael O, Harvey D, Fletcher E, Reed B, Mungas D, DeCarli C (2013) Flair and diffusion MRI signals are independent predictors of white matter hyperintensities. AJNR Am J Neuroradiol 34(1):54–61. doi:10.3174/ajnr.A3146 CrossRefPubMedPubMedCentral

Manfredi R, Nanetti A, Valentini R, Calza L, Chiodo F (2002) Frequency, epidemiology, risk factors, clinical and bacteriological features of enterococcal disease in patients with HIV infection in a decade survey. New Microbiol 25(2):179–186PubMed

Marsh HW, Wen Z, Hau KT, Little TD, Bovaird JA, Widaman KF (2007) Unconstrained structural equation models of latent interactions: contrasting residual-and mean-centered approaches. Struct Equ Model 14(4):570–580. doi:10.1080/10705510701303921 CrossRef

Meier IB, Manly JJ, Provenzano FA, Louie KS, Wasserman BT, Griffith EY, Hector JT, Allocco E, Brickman AM (2012) White matter predictors of cognitive functioning in older adults. J Int Neuropsychol Soc 18(3):414–427. doi:10.1017/S1355617712000227 CrossRefPubMedPubMedCentral

Morgan EE, Iudicello JE, Weber E, Duarte NA, Riggs PK, Delano-Wood L, Ellis R, Grant I, Woods SP, Group HIVNRP (2012) Synergistic effects of HIV infection and older age on daily functioning. J Acquir Immune Defic Syndr 61(3):341–348. doi:10.1097/QAI.0b013e31826bfc53 CrossRefPubMedPubMedCentral

Nath A, Anderson C, Jones M, Maragos W, Booze R, Mactutus C, Bell J, Hauser KF, Mattson M (2000) Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia. J Psychopharmacol 14(3):222–227. doi:10.1177/026988110001400305 CrossRefPubMed

Nir TM, Jahanshad N, Busovaca E, Wendelken L, Nicolas K, Thompson PM, Valcour VG (2014) Mapping white matter integrity in elderly people with HIV. Hum Brain Mapp 35(3):975–992. doi:10.1002/hbm.22228 CrossRefPubMedPubMedCentral

Pfefferbaum A, Sullivan EV, Hedehus M, Lim KO, Adalsteinsson E, Moseley M (2000) Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn Reson Med 44(2):259–268. doi:10.1002/1522-2594(200008)44:2<259::AID-MRM13>3.0.CO;2-6 CrossRefPubMed

Pfefferbaum A, Rogosa DA, Rosenbloom MJ, Chu W, Sassoon SA, Kemper CA, Deresinski S, Rohlfing T, Zahr NM, Sullivan EV (2014) Accelerated aging of selective brain structures in human immunodeficiency virus infection: a controlled, longitudinal magnetic resonance imaging study. Neurobiol Aging 35(7):1755–1768. doi:10.1016/j.neurobiolaging.2014.01.008 CrossRefPubMedPubMedCentral

Pomara N, Crandall DT, Choi SJ, Johnson G, Lim KO (2001) White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study. Psychiatry Res 106(1):15–24. doi:10.1016/S0925-4927(00)00082-2 CrossRefPubMed

Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatzikos C (2003) Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci 23(8):3295–3301PubMed

Sacktor N, Skolasky RL, Cox C, Selnes O, Becker JT, Cohen B, Martin E, Miller EN, Multicenter ACS (2010) Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus. J Neurovirol 16(5):335–341. doi:10.3109/13550284.2010.504249 CrossRefPubMedPubMedCentral

Seider TR, Luo X, Gongvatana A, Devlin K, de la Monte S, Chasman JD, Peisi Y, Tashima K, Navia B, Cohen RA (2014) Verbal memory declines more rapidly with age in HIV infected versus uninfected adults. Submitted for publication. J Clin Exp Neuropsychol 36(4):356–367. doi:10.1080/13803395.2014.892061 CrossRefPubMedPubMedCentral

Simioni S, Cavassini M, Annoni JM, Rimbault Abraham A, Bourquin I, Schiffer V, Calmy A, Chave JP, Giacobini E, Hirschel B, Du Pasquier RA (2010) Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS 24(9):1243–1250. doi:10.1097/QAD.0b013e3283354a7b PubMed

Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM (2004) Advances in functional and structural mr image analysis and implementation as FSL. Neuroimage 23(Suppl 1):S208–219. doi:10.1016/j.neuroimage.2004.07.051 CrossRefPubMed

Thomas JB, Brier MR, Snyder AZ, Vaida FF, Ances BM (2013) Pathways to neurodegeneration: effects of HIV and aging on resting-state functional connectivity. Neurology 80(13):1186–1193. doi:10.1212/WNL.0b013e318288792b CrossRefPubMedPubMedCentral

Thurnher MM, Castillo M, Stadler A, Rieger A, Schmid B, Sundgren PC (2005) Diffusion-tensor mr imaging of the brain in human immunodeficiency virus-positive patients. AJNR Am J Neuroradiol 26(9):2275–2281PubMed

van Sighem AI, Gras LA, Reiss P, Brinkman K, de Wolf F, Study Anoc (2010) Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals. AIDS 24(10):1527–1535. doi:10.1097/QAD.0b013e32833a3946 CrossRefPubMed

Vernooij MW, Ikram MA, Vrooman HA, Wielopolski PA, Krestin GP, Hofman A, Niessen WJ, Van der Lugt A, Breteler MM (2009) White matter microstructural integrity and cognitive function in a general elderly population. Arch Gen Psychiatry 66(5):545–553. doi:10.1001/archgenpsychiatry.2009.5 CrossRefPubMed

Woolrich MW, Jbabdi S, Patenaude B, Chappell M, Makni S, Behrens T, Beckmann C, Jenkinson M, Smith SM (2009) Bayesian analysis of neuroimaging data in FSL. Neuroimage 45(1 Suppl):S173–186. doi:10.1016/j.neuroimage.2008.10.055 CrossRefPubMed

Wu Y, Storey P, Cohen BA, Epstein LG, Edelman RR, Ragin AB (2006) Diffusion alterations in corpus callosum of patients with HIV. AJNR Am J Neuroradiol 27(3):656–660PubMedPubMedCentral

Xuan A, Wang GB, Shi DP, Xu JL, Li YL (2013) Initial study of magnetic resonance diffusion tensor imaging in brain white matter of early aids patients. Chin Med J (Engl) 126(14):2720–2724

Zhang Y, Brady M, Smith S (2001) Segmentation of brain MRI through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 20(1):45–57. doi:10.1109/42.906424 CrossRefPubMed

Zhu T, Zhong J, Hu R, Tivarus M, Ekholm S, Harezlak J, Ombao H, Navia B, Cohen R, Schifitto G (2013) Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study. J Neurovirol 19(1):10–23. doi:10.1007/s13365-012-0135-9 CrossRefPubMedPubMedCentral

Titel: Age exacerbates HIV-associated white matter abnormalities
verfasst von: Talia R. Seider
Assawin Gongvatana
Adam J. Woods
Huaihou Chen
Eric C. Porges
Tiffany Cummings
Stephen Correia
Karen Tashima
Ronald A. Cohen
Publikationsdatum: 01.04.2016
Verlag: Springer US
Erschienen in: Journal of NeuroVirology / Ausgabe 2/2016
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-015-0386-3

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