nach oben

Erschienen in:

26.11.2018

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals

verfasst von: Thomas A. Premeaux, Michelle L. D’Antoni, Mohamed Abdel-Mohsen, Satish K. Pillai, Kalpana J. Kallianpur, Beau K. Nakamoto, Melissa Agsalda-Garcia, Bruce Shiramizu, Cecilia M. Shikuma, Magnus Gisslén, Richard W. Price, Victor Valcour, Lishomwa C. Ndhlovu

Erschienen in: Journal of NeuroVirology | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

We previously reported that galectin-9 (Gal-9), a soluble lectin with immunomodulatory properties, is elevated in plasma during HIV infection and induces HIV transcription. The link between Gal-9 and compromised neuronal function is becoming increasingly evident; however, the association with neuroHIV remains unknown. We measured Gal-9 levels by ELISA in cerebrospinal fluid (CSF) and plasma of 70 HIV-infected (HIV+) adults stratified by age (older > 40 years and younger < 40 years) either ART suppressed or with detectable CSF HIV RNA, including a subgroup with cognitive assessments, and 18 HIV uninfected (HIV−) controls. Gal-9 tissue expression was compared in necropsy brain specimens from HIV− and HIV+ donors using gene datasets and immunohistochemistry. Among older HIV+ adults, CSF Gal-9 was elevated in the ART suppressed and CSF viremic groups compared to controls, whereas in the younger group, Gal-9 levels were elevated only in the CSF viremic group (p < 0.05). CSF Gal-9 positively correlated with age in all groups (p < 0.05). CSF Gal-9 tracked with CSF HIV RNA irrespective of age (β = 0.33; p < 0.05). Higher CSF Gal-9 in the older viremic HIV+ group correlated with worse neuropsychological test performance scores independently of age and CSF HIV RNA (p < 0.05). Furthermore, CSF Gal-9 directly correlated with myeloid activation (CSF-soluble CD163 and neopterin) in both HIV+ older groups (p < 0.05). Among HIV+ necropsy specimens, Gal-9 expression was increased in select brain regions compared to controls (p < 0.05). Gal-9 may serve as a novel neuroimmuno-modulatory protein that is involved in driving cognitive deficits in those aging with HIV and may be valuable in tracking cognitive abnormalities.

Nur mit Berechtigung zugänglich

Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerham LR, Pilcher CD, Hecht FM, Liegler T, Richman DD, Deeks SG, Pillai SK (2015) Select host restriction factors are associated with HIV persistence during antiretroviral therapy. AIDS 29(4):411–420. https://doi.org/10.1097/QAD.0000000000000572 CrossRefPubMed

Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK (2016) Human galectin-9 is a potent mediator of HIV transcription and reactivation. PLoS Pathog 12(6):e1005677. https://doi.org/10.1371/journal.ppat.1005677 CrossRefPubMedPubMedCentral

Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69(18):1789–1799. https://doi.org/10.1212/01.WNL.0000287431.88658.8b CrossRefPubMed

Asakura H, Kashio Y, Nakamura K, Seki M, Dai S, Shirato Y, Abedin MJ, Yoshida N, Nishi N, Imaizumi T, Saita N, Toyama Y, Takashima H, Nakamura T, Ohkawa M, Hirashima M (2002) Selective eosinophil adhesion to fibroblast via IFN-gamma-induced galectin-9. J Immunol 169(10):5912–5918CrossRefPubMed

Becker JT, Lopez OL, Dew MA, Aizenstein HJ (2004) Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS 18(Suppl 1):S11–S18CrossRefPubMed

Blomberg M, Jensen M, Basun H, Lannfelt L, Wahlund LO (2001) Cerebrospinal fluid tau levels increase with age in healthy individuals. Dement Geriatr Cogn Disord 12(2):127–132. https://doi.org/10.1159/000051246 CrossRefPubMed

Bottiggi KA, Chang JJ, Schmitt FA, Avison MJ, Mootoor Y, Nath A, Berger JR (2007) The HIV dementia scale: predictive power in mild dementia and HAART. J Neurol Sci 260(1–2):11–15. https://doi.org/10.1016/j.jns.2006.03.023 CrossRefPubMed

Brew BJ, Bhalla RB, Paul M, Gallardo H, McArthur JC, Schwartz MK et al (1990) Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection. Ann Neurol 28(4):556–560. https://doi.org/10.1002/ana.410280413 CrossRefPubMed

Burman J, Svenningsson A (2016) Cerebrospinal fluid concentration of galectin-9 is increased in secondary progressive multiple sclerosis. J Neuroimmunol 292:40–44. https://doi.org/10.1016/j.jneuroim.2016.01.008 CrossRefPubMed

Chen MF, Gill AJ, Kolson DL (2014a) Neuropathogenesis of HIV-associated neurocognitive disorders: roles for immune activation, HIV blipping and viral tropism. Curr Opin HIV AIDS 9(6):559–564. https://doi.org/10.1097/COH.0000000000000105 CrossRefPubMedPubMedCentral

Chen HL, Liao F, Lin TN, Liu FT (2014b) Galectins and neuroinflammation. Adv Neurobiol 9:517–542. https://doi.org/10.1007/978-1-4939-1154-7_24 CrossRefPubMed

Cinque P, Vago L, Mengozzi M, Torri V, Ceresa D, Vicenzi E, Transidico P, Vagani A, Sozzani S, Mantovani A, Lazzarin A, Poli G (1998) Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS 12(11):1327–1332CrossRefPubMed

Coban H, Robertson K, Smurzynski M, Krishnan S, Wu K, Bosch RJ, Collier AC, Ellis RJ (2017) Impact of aging on neurocognitive performance in previously antiretroviral-naive HIV-infected individuals on their first suppressive regimen. AIDS 31(11):1565–1571. https://doi.org/10.1097/QAD.0000000000001523 CrossRefPubMed

Cohen RA, Seider TR, Navia B (2015) HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease? Alzheimers Res Ther 7(1):37. https://doi.org/10.1186/s13195-015-0123-4 CrossRefPubMedPubMedCentral

Cole JH, Caan MWA, Underwood J, De Francesco D, van Zoest RA, Wit F et al (2018) No evidence for accelerated aging-related brain pathology in treated human immunodeficiency virus: longitudinal neuroimaging results from the Comorbidity in Relation to AIDS (COBRA) project. Clin Infect Dis 66(12):1899–1909. https://doi.org/10.1093/cid/cix1124 CrossRefPubMed

Cysique LA, Hey-Cunningham WJ, Dermody N, Chan P, Brew BJ, Koelsch KK (2015) Peripheral blood mononuclear cells HIV DNA levels impact intermittently on neurocognition. PLoS One 10(4):e0120488. https://doi.org/10.1371/journal.pone.0120488 CrossRefPubMedPubMedCentral

D'Antoni ML, Paul RH, Mitchell BI, Kohorn L, Fischer L, Lefebvre E et al (2018a) Improved cognitive performance and reduced monocyte activation in virally suppressed chronic HIV following dual CCR2 and CCR5 antagonism. J Acquir Immune Defic Syndr 79:108–116. https://doi.org/10.1097/QAI.0000000000001752 CrossRefPubMedPubMedCentral

D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P et al (2018b) Normalization of soluble CD163 levels after institution of antiretroviral therapy during acute HIV infection tracks with fewer neurological abnormalities. J Infect Dis 218(9):1453–1463. https://doi.org/10.1093/infdis/jiy337 CrossRefPubMedPubMedCentral

de la Fuente H, Perez-Gala S, Bonay P, Cruz-Adalia A, Cibrian D, Sanchez-Cuellar S, Dauden E, Fresno M, García-Diez A, Sanchez-Madrid F (2012) Psoriasis in humans is associated with down-regulation of galectins in dendritic cells. J Pathol 228(2):193–203. https://doi.org/10.1002/path.3996 CrossRefPubMed

de Oliveira MF, Murrel B, Perez-Santiago J, Vargas M, Ellis RJ, Letendre S et al (2015) Circulating HIV DNA correlates with neurocognitive impairment in older HIV-infected adults on suppressive ART. Sci Rep 5:17094. https://doi.org/10.1038/srep17094 CrossRefPubMedPubMedCentral

Duffau P, Ozanne A, Bonnet F, Lazaro E, Cazanave C, Blanco P, Rivière E, Desclaux A, Hyernard C, Gensous N, Pellegrin I, Wittkop L (2018) Multimorbidity, age-related comorbidities and mortality: association of activation, senescence and inflammation markers in HIV adults. AIDS 32:1651–1660. https://doi.org/10.1097/QAD.0000000000001875 CrossRefPubMed

Dzwonek J, Wilczynski GM (2015) CD44: molecular interactions, signaling and functions in the nervous system. Front Cell Neurosci 9:175. https://doi.org/10.3389/fncel.2015.00175 CrossRefPubMedPubMedCentral

Eden A, Marcotte TD, Heaton RK, Nilsson S, Zetterberg H, Fuchs D et al (2016) Increased intrathecal immune activation in virally suppressed HIV-1 infected patients with neurocognitive impairment. PLoS One 11(6):e0157160. https://doi.org/10.1371/journal.pone.0157160 CrossRefPubMedPubMedCentral

Ellis RJ, Seubert P, Motter R, Galasko D, Deutsch R, Heaton RK, Heyes MP, McCutchan JA, Hampton Atkinson J, Grant I (1998) Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans. HIV Neurobehavioral Research Center Group (HNRC). Neurosci Lett 254(1):1–4CrossRefPubMed

Gates TM, Cysique LA, Siefried KJ, Chaganti J, Moffat KJ, Brew BJ (2016) Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder. AIDS 30(4):591–600. https://doi.org/10.1097/QAD.0000000000000951 CrossRefPubMed

Gisslen M, Hagberg L, Brew BJ, Cinque P, Price RW, Rosengren L (2007) Elevated cerebrospinal fluid neurofilament light protein concentrations predict the development of AIDS dementia complex. J Infect Dis 195(12):1774–1778. https://doi.org/10.1086/518043 CrossRefPubMed

Gisslen M, Krut J, Andreasson U, Blennow K, Cinque P, Brew BJ et al (2009) Amyloid and tau cerebrospinal fluid biomarkers in HIV infection. BMC Neurol 9:63. https://doi.org/10.1186/1471-2377-9-63 CrossRefPubMedPubMedCentral

Hagberg L, Cinque P, Gisslen M, Brew BJ, Spudich S, Bestetti A, Price RW, Fuchs D (2010) Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection. AIDS Res Ther 7:15. https://doi.org/10.1186/1742-6405-7-15 CrossRefPubMedPubMedCentral

Harwood NM, Golden-Mason L, Cheng L, Rosen HR, Mengshol JA (2016) HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production. J Leukoc Biol 99(3):495–503. https://doi.org/10.1189/jlb.5A1214-582R CrossRefPubMed

Heaton RK, Marcotte TD, Mindt MR, Sadek J, Moore DJ, Bentley H et al (2004) The impact of HIV-associated neuropsychological impairment on everyday functioning. J Int Neuropsychol Soc 10(3):317–331. https://doi.org/10.1017/S1355617704102130 CrossRefPubMed

Heaton RK, Clifford DB, Franklin DR Jr, Woods SP, Ake C, Vaida F et al (2010) HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 75(23):2087–2096. https://doi.org/10.1212/WNL.0b013e318200d727 CrossRefPubMedPubMedCentral

Horie H, Inagaki Y, Sohma Y, Nozawa R, Okawa K, Hasegawa M, Muramatsu N, Kawano H, Horie M, Koyama H, Sakai I, Takeshita K, Kowada Y, Takano M, Kadoya T (1999) Galectin-1 regulates initial axonal growth in peripheral nerves after axotomy. J Neurosci 19(22):9964–9974CrossRefPubMedPubMedCentral

Horvath S, Levine AJ (2015) HIV-1 infection accelerates age according to the epigenetic clock. J Infect Dis 212(10):1563–1573. https://doi.org/10.1093/infdis/jiv277 CrossRefPubMedPubMedCentral

Hu J, Ferreira A, Van Eldik LJ (1997) S100beta induces neuronal cell death through nitric oxide release from astrocytes. J Neurochem 69(6):2294–2301CrossRefPubMed

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid. beta Sci Transl Med 4(147):147ra11. https://doi.org/10.1126/scitranslmed.3003748 CrossRef

Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M, Nishi N, Fujimoto K, Tanji K, Shibata T, Tamo W, Matsumiya T, Yoshida H, Cui XF, Takanashi S, Hanada K, Okumura K, Yagihashi S, Wakabayashi K, Nakamura T, Hirashima M, Satoh K (2002) Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. J Leukoc Biol 72(3):486–491PubMed

Ishikawa A, Imaizumi T, Yoshida H, Nishi N, Nakamura T, Hirashima M, Satoh K (2004) Double-stranded RNA enhances the expression of galectin-9 in vascular endothelial cells. Immunol Cell Biol 82(4):410–414. https://doi.org/10.1111/j.0818-9641.2004.01248.x CrossRefPubMed

Jiang HR, Al Rasebi Z, Mensah-Brown E, Shahin A, Xu D, Goodyear CS et al (2009) Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis. J Immunol 182(2):1167–1173CrossRefPubMed

John CM, Jarvis GA, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JML (2002) Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol 4(10):649–662CrossRefPubMed

Kurose Y, Wada J, Kanzaki M, Teshigawara S, Nakatsuka A, Murakami K, Inoue K, Terami T, Katayama A, Watanabe M, Higuchi C, Eguchi J, Miyatake N, Makino H (2013) Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease. BMC Nephrol 14:23. https://doi.org/10.1186/1471-2369-14-23 CrossRefPubMedPubMedCentral

Kusao I, Shiramizu B, Liang CY, Grove J, Agsalda M, Troelstrup D, Velasco VN, Marshall A, Whitenack N, Shikuma C, Valcour V (2012) Cognitive performance related to HIV-1-infected monocytes. J Neuropsychiatr Clin Neurosci 24(1):71–80. https://doi.org/10.1176/appi.neuropsych.11050109 CrossRef

Lerman BJ, Hoffman EP, Sutherland ML, Bouri K, Hsu DK, Liu FT, Rothstein JD, Knoblach SM (2012) Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Brain Behav 2(5):563–575. https://doi.org/10.1002/brb3.75 CrossRefPubMedPubMedCentral

Letendre S (2011) Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder. Top Antivir Med 19(4):137–142PubMed

Liu Z, Han H, He X, Li S, Wu C, Yu C et al (2016) Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. Oncol Lett 11(3):1829–1834. https://doi.org/10.3892/ol.2016.4142 CrossRefPubMedPubMedCentral

Lv K, Zhang Y, Zhang M, Zhong M, Suo Q (2013) Galectin-9 promotes TGF-beta1-dependent induction of regulatory T cells via the TGF-beta/Smad signaling pathway. Mol Med Rep 7(1):205–210. https://doi.org/10.3892/mmr.2012.1125 CrossRefPubMed

Mahy M, Autenrieth CS, Stanecki K, Wynd S (2014) Increasing trends in HIV prevalence among people aged 50 years and older: evidence from estimates and survey data. AIDS 28(Suppl 4):S453–S459. https://doi.org/10.1097/QAD.0000000000000479 CrossRefPubMed

Mellgren A, Price RW, Hagberg L, Rosengren L, Brew BJ, Gisslen M (2007) Antiretroviral treatment reduces increased CSF neurofilament protein (NFL) in HIV-1 infection. Neurology 69(15):1536–1541. https://doi.org/10.1212/01.wnl.0000277635.05973.55 CrossRefPubMed

Nakamoto BK, Valcour VG, Kallianpur K, Liang CY, McMurtray A, Chow D, Kappenburg E, Shikuma CM (2011) Impact of cerebrovascular disease on cognitive function in HIV-infected patients. J Acquir Immune Defic Syndr 57(3):e66–e68. https://doi.org/10.1097/QAI.0b013e31821ff8bd CrossRefPubMedPubMedCentral

Ndhlovu LC, Umaki T, Chew GM, Chow DC, Agsalda M, Kallianpur KJ, Paul R, Zhang G, Ho E, Hanks N, Nakamoto B, Shiramizu BT, Shikuma CM (2014) Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND). J Neuro-Oncol 20(6):571–582. https://doi.org/10.1007/s13365-014-0279-x CrossRef

Parikh NU, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Mammen MJ, Schwartz SA, Mahajan SD (2015) Galectin-1 suppresses methamphetamine induced neuroinflammation in human brain microvascular endothelial cells: Neuroprotective role in maintaining blood brain barrier integrity. Brain Res 1624:175–187. https://doi.org/10.1016/j.brainres.2015.07.033 CrossRefPubMedPubMedCentral

Peluso MJ, Meyerhoff DJ, Price RW, Peterson J, Lee E, Young AC, Walter R, Fuchs D, Brew BJ, Cinque P, Robertson K, Hagberg L, Zetterberg H, Gisslen M, Spudich S (2013) Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary HIV infection. J Infect Dis 207(11):1703–1712. https://doi.org/10.1093/infdis/jit088 CrossRefPubMedPubMedCentral

Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett BL, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW (2014) Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection. PLoS One 9(12):e116081. https://doi.org/10.1371/journal.pone.0116081 CrossRefPubMedPubMedCentral

Rahimy E, Li FY, Hagberg L, Fuchs D, Robertson K, Meyerhoff DJ, Zetterberg H, Price RW, Gisslén M, Spudich S (2017) Blood-brain barrier disruption is initiated during primary HIV infection and not rapidly altered by antiretroviral therapy. J Infect Dis 215(7):1132–1140. https://doi.org/10.1093/infdis/jix013 CrossRefPubMedPubMedCentral

Robertson KR, Smurzynski M, Parsons TD, Wu K, Bosch RJ, Wu J, McArthur JC, Collier AC, Evans SR, Ellis RJ (2007) The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS 21(14):1915–1921. https://doi.org/10.1097/QAD.0b013e32828e4e27 CrossRefPubMed

Saitoh H, Ashino Y, Chagan-Yasutan H, Niki T, Hirashima M, Hattori T (2012) Rapid decrease of plasma galectin-9 levels in patients with acute HIV infection after therapy. Tohoku J Exp Med 228(2):157–161CrossRefPubMed

Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H (2006) A carbohydrate-binding protein, galectin-1, promotes proliferation of adult neural stem cells. Proc Natl Acad Sci U S A 103(18):7112–7117. https://doi.org/10.1073/pnas.0508793103 CrossRefPubMedPubMedCentral

Schouten J, Wit FW, Stolte IG, Kootstra NA, van der Valk M, Geerlings SE, Prins M, Reiss P, for the AGEhIV Cohort Study Group, Reiss P, Wit FWNM, van der Valk M, Schouten J, Kooij KW, van Zoest RA, Elsenga BC, Prins M, Stolte IG, Martens M, Moll S, Berkel J, Moller L, Visser GR, Welling C, Zaheri S, Hillebregt MMJ, Gras LAJ, Ruijs YMC, Benschop DP, Reiss P, Kootstra NA, Harskamp-Holwerda AM, Maurer I, Mangas Ruiz MM, Girigorie AF, van Leeuwen E, Janssen FR, Heidenrijk M, Schrijver JHN, Zikkenheiner W, Wezel M, Jansen-Kok CSM, Geerlings SE, Godfried MH, Goorhuis A, van der Meer JTM, Nellen FJB, van der Poll T, Prins JM, Reiss P, van der Valk M, Wiersinga WJ, Wit FWNM, van Eden J, Henderiks A, van Hes AMH, Mutschelknauss M, Nobel HE, Pijnappel FJJ, Westerman AM, de Jong J, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, de Rooij SEJA, Willemsen JMR, Vogt L, Schouten J, Portegies P, Schmand BA, Geurtsen GJ, ter Stege JA, Klein Twennaar M, van Eck-Smit BLF, de Jong M, Richel DJ, Verbraak FD, Demirkaya N, Visser I, Ruhe HG, Nieuwkerk PT, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, Su T, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC (2014) Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study. Clin Infect Dis 59(12):1787–1797. https://doi.org/10.1093/cid/ciu701 CrossRefPubMed

Sehrawat S, Reddy PB, Rajasagi N, Suryawanshi A, Hirashima M, Rouse BT (2010) Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response. PLoS Pathog 6(5):e1000882. https://doi.org/10.1371/journal.ppat.1000882 CrossRefPubMedPubMedCentral

Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M (2008) Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 127(1):78–88. https://doi.org/10.1016/j.clim.2008.01.006 CrossRefPubMed

Sevigny JJ, Albert SM, McDermott MP, McArthur JC, Sacktor N, Conant K et al (2004) Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology 63(11):2084–2090CrossRefPubMed

Shin T (2013) The pleiotropic effects of galectin-3 in neuroinflammation: a review. Acta Histochem 115(5):407–411. https://doi.org/10.1016/j.acthis.2012.11.010 CrossRefPubMed

Spudich S, Gonzalez-Scarano F (2012) HIV-1-related central nervous system disease: current issues in pathogenesis, diagnosis, and treatment. Cold Spring Harb Perspect Med 2(6):a007120. https://doi.org/10.1101/cshperspect.a007120 CrossRefPubMedPubMedCentral

Stancic M, van Horssen J, Thijssen VL, Gabius HJ, van der Valk P, Hoekstra D, Baron W (2011) Increased expression of distinct galectins in multiple sclerosis lesions. Neuropathol Appl Neurobiol 37(6):654–671. https://doi.org/10.1111/j.1365-2990.2011.01184.x CrossRefPubMed

Steelman AJ, Li J (2014) Astrocyte galectin-9 potentiates microglial TNF secretion. J Neuroinflammation 11:144. https://doi.org/10.1186/s12974-014-0144-0 CrossRefPubMedPubMedCentral

Steelman AJ, Smith R 3rd, Welsh CJ, Li J (2013) Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem 288(33):23776–23787. https://doi.org/10.1074/jbc.M113.451658 CrossRefPubMedPubMedCentral

Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN, Deeks SG, Ndhlovu LC (2014) Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers. AIDS Res Hum Retrovir 30(7):654–664. https://doi.org/10.1089/AID.2014.0004 CrossRefPubMedPubMedCentral

Tedaldi EM, Minniti NL, Fischer T (2015) HIV-associated neurocognitive disorders: the relationship of HIV infection with physical and social comorbidities. Biomed Res Int 2015:641913–641913. https://doi.org/10.1155/2015/641913 CrossRefPubMedPubMedCentral

The Human Protein Atlas (n.d.) http://www.proteinatlas.org/ENSG00000168961-LGALS9/tissue. Accessed 23 Aug 2016

Vagberg M, Norgren N, Dring A, Lindqvist T, Birgander R, Zetterberg H et al (2015) Levels and age dependency of neurofilament light and glial fibrillary acidic protein in healthy individuals and their relation to the brain parenchymal fraction. PLoS One 10(8):e0135886. https://doi.org/10.1371/journal.pone.0135886 CrossRefPubMedPubMedCentral

Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Holck P, Grove J, Sacktor N (2004) Higher frequency of dementia in older HIV-1 individuals: the Hawaii aging with HIV-1 cohort. Neurology 63(5):822–827CrossRefPubMed

Valcour VG, Ananworanich J, Agsalda M, Sailasuta N, Chalermchai T, Schuetz A, Shikuma C, Liang CY, Jirajariyavej S, Sithinamsuwan P, Tipsuk S, Clifford DB, Paul R, Fletcher JLK, Marovich MA, Slike BM, DeGruttola V, Shiramizu B, for the SEARCH 011 Protocol Team (2013) HIV DNA reservoir increases risk for cognitive disorders in cART-naive patients. PLoS One 8(7):e70164. https://doi.org/10.1371/journal.pone.0070164 CrossRefPubMedPubMedCentral

Valle M, Price RW, Nilsson A, Heyes M, Verotta D (2004) CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy. Brain 127(Pt 5):1047–1060. https://doi.org/10.1093/brain/awh130 CrossRefPubMed

Wada J, Kanwar YS (1997) Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin. J Biol Chem 272(9):6078–6086CrossRefPubMed

Wang HW, Zhu XL, Qin LM, Qian HJ, Wang Y (2015) Microglia activity modulated by T cell Ig and mucin domain protein 3 (Tim-3). Cell Immunol 293(1):49–58. https://doi.org/10.1016/j.cellimm.2014.12.005 CrossRefPubMed

Wright EJ, Grund B, Robertson K, Brew BJ, Roediger M, Bain MP, Drummond F, Vjecha MJ, Hoy J, Miller C, Penalva de Oliveira AC, Pumpradit W, Shlay JC, el-Sadr W, Price RW, For the INSIGHT SMART Study Group (2010) Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons. Neurology 75(10):864–873. https://doi.org/10.1212/WNL.0b013e3181f11bd8 CrossRefPubMedPubMedCentral

Yeo YA, Martinez Gomez JM, Croxford JL, Gasser S, Ling EA, Schwarz H (2012) CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species. J Neuroinflammation 9:173. https://doi.org/10.1186/1742-2094-9-173 CrossRefPubMedPubMedCentral

Yilmaz A, Blennow K, Hagberg L, Nilsson S, Price RW, Schouten J, Spudich S, Underwood J, Zetterberg H, Gisslén M (2017) Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls. Expert Rev Mol Diagn 17(8):761–770. https://doi.org/10.1080/14737159.2017.1341313 CrossRefPubMed

Yoshida H, Imaizumi T, Kumagai M, Kimura K, Satoh C, Hanada N, Fujimoto K, Nishi N, Tanji K, Matsumiya T, Mori F, Cui XF, Tamo W, Shibata T, Takanashi S, Okumura K, Nakamura T, Wakabayashi K, Hirashima M, Sato Y, Satoh K (2001) Interleukin-1beta stimulates galectin-9 expression in human astrocytes. Neuroreport 12(17):3755–3758CrossRefPubMed

Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6(12):1245–1252. https://doi.org/10.1038/ni1271 CrossRefPubMed

Titel: Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals
verfasst von: Thomas A. Premeaux
Michelle L. D’Antoni
Mohamed Abdel-Mohsen
Satish K. Pillai
Kalpana J. Kallianpur
Beau K. Nakamoto
Melissa Agsalda-Garcia
Bruce Shiramizu
Cecilia M. Shikuma
Magnus Gisslén
Richard W. Price
Victor Valcour
Lishomwa C. Ndhlovu
Publikationsdatum: 26.11.2018
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 2/2019
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0696-3

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2019

Initiation of antiretroviral therapy after the critical neuronal developmental period of the second postnatal year affects white matter microstructure in adolescents living with HIV

Headache prevalence and its functional impact among HIV-infected adults in rural Rakai District, Uganda

Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes

Progressive multifocal leukoencephalopathy treated with nivolumab

The role of HHV-6 and HHV-7 infections in the development of fibromyalgia

Neuroinvasion of influenza A/H3N2: a fatal case in an immunocompetent adult

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie