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Erschienen in: Journal of NeuroVirology 1/2020

08.07.2019 | Case Report

Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis

verfasst von: T. Singhal, I. Solomon, F. Akbik, S. Smirnakis, H. Vaitkevicius

Erschienen in: Journal of NeuroVirology | Ausgabe 1/2020

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Abstract

A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly elevated protein but herpes simplex virus (HSV) polymerase chain reaction (PCR) was negative. A repeat CSF examination performed 9 days later showed a positive HSV PCR. Histopathological and immunohistochemical examination of autopsy specimen confirmed the presence of CD45+ lymphocytes and HSV antigen, suggesting the presence of both inflammation and viral infection corresponding to PET abnormality.
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Metadaten
Titel
Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis
verfasst von
T. Singhal
I. Solomon
F. Akbik
S. Smirnakis
H. Vaitkevicius
Publikationsdatum
08.07.2019
Verlag
Springer International Publishing
Erschienen in
Journal of NeuroVirology / Ausgabe 1/2020
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-019-00779-2

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