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Cellular Oncology
Erschienen in: Cellular Oncology 2/2018

22.03.2018 | Review

Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis

verfasst von: Meysam Yousefi, Rahim Nosrati, Arash Salmaninejad, Sadegh Dehghani, Alireza Shahryari, Alihossein Saberi

Erschienen in: Cellular Oncology | Ausgabe 2/2018

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Abstract

Background

Breast cancer (BC) is the most common type of cancer in women and the second cause of cancer-related mortality world-wide. The majority of BC-related deaths is due to metastasis. Bone, lung, brain and liver are the primary target sites of BC metastasis. The clinical implications and mechanisms underlying bone metastasis have been reviewed before. Given the fact that BC lung metastasis (BCLM) usually produces symptoms only after the lungs have been vastly occupied with metastatic tumor masses, it is of paramount importance for diagnostic and prognostic, as well as therapeutic purposes to comprehend the molecular and cellular mechanisms underlying BCLM. Here, we review current insights into the organ-specificity of BC metastasis, including the role of cancer stem cells in triggering BC spread, the traveling of tumor cells in the blood stream and their migration across endothelial barriers, their adaptation to the lung microenvironment and the initiation of metastatic colonization within the lung.

Conclusions

Detailed understanding of the mechanisms underlying BCLM will shed a new light on the identification of novel molecular targets to impede daunting pulmonary metastases in patients with breast cancer.
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Metadaten
Titel
Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis
verfasst von
Meysam Yousefi
Rahim Nosrati
Arash Salmaninejad
Sadegh Dehghani
Alireza Shahryari
Alihossein Saberi
Publikationsdatum
22.03.2018
Verlag
Springer Netherlands
Erschienen in
Cellular Oncology / Ausgabe 2/2018
Print ISSN: 2211-3428
Elektronische ISSN: 2211-3436
DOI
https://doi.org/10.1007/s13402-018-0376-6

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