Fig. 2
Suggested beneficial effects of electrical muscle stimulation (EMS) with regard to muscle hypertrophy, atrophy, aerobic capacity, membrane excitability and membrane translocation of GLUT4. EMS may preserve membrane excitability. Membrane translocation of GLUT4 is regulated by IGF-1, AMPK, PGC-1α and its downstream targets, which may all be affected by EMS. Atrophy gene expression (MuRF-1, atrogin-1) increases upon desphosphorylation of FoxO3 trancription factors, which is inhibited by downstream insulin signalling. EMS electrical muscle stimulation, IGF-1 insulin growth factor-1, GLUT4 glucose transporter 4, IRS-1 insulin receptor substrate 1, AMPK AMP-activated protein kinase, PI3K phopshoinositide 3-kinase, PPAR peroxisome proliferator-activated receptor, PGC-1α PPAR-γ coactivator 1α, pAKT phosphorylated Akt protein kinase B, mTOR mammalian target of rapamycin, FoxO3 forkhead box O3, MuRF muscle-specific ring finger protein