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Acta Neurologica Belgica

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01.06.2014 | Review Article

Imaging predictors of outcome following intravenous thrombolysis in acute stroke

verfasst von: Archana Hinduja

Erschienen in: Acta Neurologica Belgica | Ausgabe 2/2014

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Abstract

Intravenous tissue plasminogen activator is the only approved medical treatment for patients with acute ischemic stroke. While it is associated with excellent clinical outcome in about 30 %, even with timely thrombolysis administration, certain strokes continue to evolve and lead to poor outcomes. Several studies have attempted to identify predictors of outcome despite timely thrombolysis. Persistence of a proximal clot burden and large vessel occlusion following thrombolysis are markers for patients who may potentially benefit from advanced treatment modalities like intra-arterial thrombolysis and thrombectomy. Timely brain imaging and interpretation play a crucial role in providing these treatment decisions. In this review, various imaging predictors of poor outcome among patients with acute ischemic stroke treated with intravenous thrombolysis are outlined. Despite identification of these imaging predictors, thrombolysis should not be withheld, as it may still be beneficial in a subset of patients. Knowledge of these predictors may set benchmarks for selecting candidates who may potentially benefit from advanced management strategies in future trials.

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Titel: Imaging predictors of outcome following intravenous thrombolysis in acute stroke
verfasst von: Archana Hinduja
Publikationsdatum: 01.06.2014
Verlag: Springer Milan
Erschienen in: Acta Neurologica Belgica / Ausgabe 2/2014
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-013-0270-y

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Imaging predictors of outcome following intravenous thrombolysis in acute stroke

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