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Erschienen in: American Journal of Clinical Dermatology 4/2015

01.08.2015 | Review Article

Dermal Fillers: An Update

verfasst von: Annelyse Cristine Ballin, Fredric S. Brandt, Alex Cazzaniga

Erschienen in: American Journal of Clinical Dermatology | Ausgabe 4/2015

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Abstract

Injection of dermal fillers is the second most frequent nonsurgical cosmetic procedure performed in the USA. Dermal fillers are an option in the treatment of volume deficiency, scars, and rhytides; facial sculpting; facial contouring; and augmentation of specific anatomical sites such as the lips. The number of injectable dermal fillers available on the market increases yearly. Dermatologists and cosmetic surgeons should regularly review treatment options to provide patients with safe and effective filler options. This paper extensively reviews the properties of the available fillers, such as their rheology, longevity, and adverse effects, and how these properties affect the choice of filler agent for a particular patient or a particular site. Also, trends in dermal filler injections are discussed.
Literatur
3.
4.
Zurück zum Zitat Brandt FS, Kaufman J, Green JB, Ballin AC, Cazzaniga A. Hyaluronic acid fillers. In: Nouri K, editor. Dermatologic surgery: step by step. Oxford: Wiley-Blackwell; 2012. p. 259–85. Brandt FS, Kaufman J, Green JB, Ballin AC, Cazzaniga A. Hyaluronic acid fillers. In: Nouri K, editor. Dermatologic surgery: step by step. Oxford: Wiley-Blackwell; 2012. p. 259–85.
5.
Zurück zum Zitat Vleggaar D, Fitzgerald R. Dermatological implications of skeletal aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7(3):209–20.PubMed Vleggaar D, Fitzgerald R. Dermatological implications of skeletal aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7(3):209–20.PubMed
6.
Zurück zum Zitat Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plastic Reconstr Surg. 2007;119:2219–27.CrossRef Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plastic Reconstr Surg. 2007;119:2219–27.CrossRef
7.
Zurück zum Zitat Lemperle G, Romano JJ, Busso M. Soft tissue augmentation with Artecoll: 10-year history, indications, techniques, and complications. Dermatol Surg. 2003;29(6):573–87.PubMed Lemperle G, Romano JJ, Busso M. Soft tissue augmentation with Artecoll: 10-year history, indications, techniques, and complications. Dermatol Surg. 2003;29(6):573–87.PubMed
8.
Zurück zum Zitat Kontis TC. Contemporary review of injectable facial fillers. JAMA Facial Plast Surg. 2013;15(1):58–64.PubMedCrossRef Kontis TC. Contemporary review of injectable facial fillers. JAMA Facial Plast Surg. 2013;15(1):58–64.PubMedCrossRef
9.
Zurück zum Zitat Conejo-Mir JS, Sanz Guirado S, Angel Munoz M. Adverse granulomatous reaction to Artecoll treated by intralesional 5-fluorouracil and triamcinolone injections. Dermatol Surg. 2006;32:1079–81.PubMed Conejo-Mir JS, Sanz Guirado S, Angel Munoz M. Adverse granulomatous reaction to Artecoll treated by intralesional 5-fluorouracil and triamcinolone injections. Dermatol Surg. 2006;32:1079–81.PubMed
10.
Zurück zum Zitat Lemperle G, Gauthier-Hazan N, Wolters M, Eisemann-Klein M, Zimmermann U, Duffy DM. Foreign body granulomas after all injectable dermal fillers: part 1. Possible causes. Plast Reconstr Surg. 2009;123:1842–63.PubMedCrossRef Lemperle G, Gauthier-Hazan N, Wolters M, Eisemann-Klein M, Zimmermann U, Duffy DM. Foreign body granulomas after all injectable dermal fillers: part 1. Possible causes. Plast Reconstr Surg. 2009;123:1842–63.PubMedCrossRef
11.
Zurück zum Zitat Lemperle G, Knapp TR, Sadick NS, Lemperle SM. ArteFill permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques. Aesthetic Plast Surg. 2010;34(3):264–72.PubMedCentralPubMedCrossRef Lemperle G, Knapp TR, Sadick NS, Lemperle SM. ArteFill permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques. Aesthetic Plast Surg. 2010;34(3):264–72.PubMedCentralPubMedCrossRef
12.
Zurück zum Zitat Sclafani AP, Fagien S. Treatment of injectable soft tissue filler complications. Dermatol Surg. 2009;35(Suppl 2):1672–80.PubMedCrossRef Sclafani AP, Fagien S. Treatment of injectable soft tissue filler complications. Dermatol Surg. 2009;35(Suppl 2):1672–80.PubMedCrossRef
13.
Zurück zum Zitat Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol. 2013;12(6):295–316. Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol. 2013;12(6):295–316.
15.
Zurück zum Zitat Karnik J, Baumann L, Bruce S, Callender V, Cohen S, Grimes P, Joseph J, Shamban A, Spencer J, Tedaldi R, Werschler WP, Smith SR. A double-blind, randomized, multicenter, controlled trial of suspended polymethylmethacrylate microspheres for the correction of atrophic facial acne scars. J Am Acad Dermatol. 2014;71(1):77–83.PubMedCrossRef Karnik J, Baumann L, Bruce S, Callender V, Cohen S, Grimes P, Joseph J, Shamban A, Spencer J, Tedaldi R, Werschler WP, Smith SR. A double-blind, randomized, multicenter, controlled trial of suspended polymethylmethacrylate microspheres for the correction of atrophic facial acne scars. J Am Acad Dermatol. 2014;71(1):77–83.PubMedCrossRef
16.
Zurück zum Zitat Goldberg D, Guana A, Volk A, et al. Single-arm study for the characterization of human tissue response to injectable poly-l-lactic acid. Dermatol Surg. 2013;39:915–22.PubMedCrossRef Goldberg D, Guana A, Volk A, et al. Single-arm study for the characterization of human tissue response to injectable poly-l-lactic acid. Dermatol Surg. 2013;39:915–22.PubMedCrossRef
17.
Zurück zum Zitat Vleggaar D. Facial volumetric correction with injectable poly-l-lactic acid. Dermatol Surg. 2005;3:1511–7.CrossRef Vleggaar D. Facial volumetric correction with injectable poly-l-lactic acid. Dermatol Surg. 2005;3:1511–7.CrossRef
18.
Zurück zum Zitat Brandt FS, Cazzaniga A, Baumann L, Fagien S, Glazer S, Kenkel JM, Lowe NJ, Monheit GD, Narins RS, Rendon MI, Rohrich RJ, Werschler WP. Investigator global evaluations of efficacy of injectable poly-l-lactic acid versus human collagen in the correction of nasolabial fold wrinkles. Aesthet Surg J. 2011;31(5):521–8.PubMedCrossRef Brandt FS, Cazzaniga A, Baumann L, Fagien S, Glazer S, Kenkel JM, Lowe NJ, Monheit GD, Narins RS, Rendon MI, Rohrich RJ, Werschler WP. Investigator global evaluations of efficacy of injectable poly-l-lactic acid versus human collagen in the correction of nasolabial fold wrinkles. Aesthet Surg J. 2011;31(5):521–8.PubMedCrossRef
19.
Zurück zum Zitat Fitzgerald R, Vleggaar D. Facial volume restoration of the aging face with poly-l-lactic acid. Dermatol Ther. 2011;24:2–27.PubMedCrossRef Fitzgerald R, Vleggaar D. Facial volume restoration of the aging face with poly-l-lactic acid. Dermatol Ther. 2011;24:2–27.PubMedCrossRef
20.
Zurück zum Zitat Rossner F, Rossner M, Hartmann V, Erdmann R, Wiest LG, Rzany B. Decrease of reported events to injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety Study. J Cosmet Dermatol. 2009;8(1):14–8.PubMedCrossRef Rossner F, Rossner M, Hartmann V, Erdmann R, Wiest LG, Rzany B. Decrease of reported events to injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety Study. J Cosmet Dermatol. 2009;8(1):14–8.PubMedCrossRef
21.
Zurück zum Zitat Woerle B, Hanke CW, Sattler G. Poly-l-lactic acid: a temporary filler for soft tissue augmentation. J Drugs Dermatol. 2004;3(4):385–9.PubMed Woerle B, Hanke CW, Sattler G. Poly-l-lactic acid: a temporary filler for soft tissue augmentation. J Drugs Dermatol. 2004;3(4):385–9.PubMed
22.
Zurück zum Zitat Alessio R, Rzany B, Eve L, Grangier Y, Herranz P, Olivier-Masveyraud F, Vleggaar D. European expert recommendations on the use of injectable poly-l-lactic acid for facial rejuvenation. J Drugs Dermatol. 2014;13(9):1057–66.PubMed Alessio R, Rzany B, Eve L, Grangier Y, Herranz P, Olivier-Masveyraud F, Vleggaar D. European expert recommendations on the use of injectable poly-l-lactic acid for facial rejuvenation. J Drugs Dermatol. 2014;13(9):1057–66.PubMed
23.
Zurück zum Zitat Palm MD, Goldman MP. Patient satisfaction and duration of effect with PLLA: a review of the literature. J Drugs Dermatol. 2009;8(10):s15–20.PubMed Palm MD, Goldman MP. Patient satisfaction and duration of effect with PLLA: a review of the literature. J Drugs Dermatol. 2009;8(10):s15–20.PubMed
24.
Zurück zum Zitat Smith S, Busso M, McClaren M, Bass LS. A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for the correction of nasolabial folds. Dermatol Surg. 2007;33(Suppl 2):S112–21 (discussion S121).PubMed Smith S, Busso M, McClaren M, Bass LS. A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for the correction of nasolabial folds. Dermatol Surg. 2007;33(Suppl 2):S112–21 (discussion S121).PubMed
25.
Zurück zum Zitat Moers-Carpi M, Vogt S, Santos BM, Planas J, Vallve SR, Howell DJ. A multicenter, randomized trial comparing calcium hydroxylapatite to two hyaluronic acids for treatment of nasolabial folds. Dermatol Surg. 2007;33(Suppl 2):S144–51.PubMed Moers-Carpi M, Vogt S, Santos BM, Planas J, Vallve SR, Howell DJ. A multicenter, randomized trial comparing calcium hydroxylapatite to two hyaluronic acids for treatment of nasolabial folds. Dermatol Surg. 2007;33(Suppl 2):S144–51.PubMed
26.
Zurück zum Zitat Moers-Carpi MM, Tufet JO. Calcium hydroxylapatite versus nonanimal stabilized hyaluronic acid for the correction of nasolabial folds: a 12-month, multicenter, prospective, randomized, controlled, split-face trial. Dermatol Surg. 2008;34(2):210–5.PubMedCrossRef Moers-Carpi MM, Tufet JO. Calcium hydroxylapatite versus nonanimal stabilized hyaluronic acid for the correction of nasolabial folds: a 12-month, multicenter, prospective, randomized, controlled, split-face trial. Dermatol Surg. 2008;34(2):210–5.PubMedCrossRef
27.
Zurück zum Zitat Bass LS, Smith S, Busso M, McClaren M. Calcium hydroxylapatite (Radiesse) for treatment of nasolabial folds: long-term safety and efficacy results. Aesthet Surg J. 2010;30(2):235–8.PubMedCrossRef Bass LS, Smith S, Busso M, McClaren M. Calcium hydroxylapatite (Radiesse) for treatment of nasolabial folds: long-term safety and efficacy results. Aesthet Surg J. 2010;30(2):235–8.PubMedCrossRef
28.
Zurück zum Zitat Graivier MH, Bass LS, Busso M, Jasin ME, Narins RS, Tzikas TL. Calcium hydroxylapatite (Radiesse) for correction of the mid-and lower face: consensus recommendations. Plast Reconstr Surg. 2007;120(6 Suppl):55S–66S.PubMedCrossRef Graivier MH, Bass LS, Busso M, Jasin ME, Narins RS, Tzikas TL. Calcium hydroxylapatite (Radiesse) for correction of the mid-and lower face: consensus recommendations. Plast Reconstr Surg. 2007;120(6 Suppl):55S–66S.PubMedCrossRef
29.
Zurück zum Zitat Daley T, Damm DD, Haden JA, Kolodychak MT. Oral lesions associated with injected hydroxyapatite cosmetic filler. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(1):107–11.PubMedCrossRef Daley T, Damm DD, Haden JA, Kolodychak MT. Oral lesions associated with injected hydroxyapatite cosmetic filler. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(1):107–11.PubMedCrossRef
30.
Zurück zum Zitat Tzikas TL. A 52-month summary of results using calcium hydroxylapatite for facial soft tissue augmentation. Dermatol Surg. 2008;34(Suppl 1):S9–15.PubMed Tzikas TL. A 52-month summary of results using calcium hydroxylapatite for facial soft tissue augmentation. Dermatol Surg. 2008;34(Suppl 1):S9–15.PubMed
31.
Zurück zum Zitat Emer J, Sundaram H. Aesthetic applications of calcium hydroxylapatite volumizing filler: an evidence-based review and discussion of current concepts (part 1 of 2). J Drugs Dermatol. 2013;12(12):1345–54.PubMed Emer J, Sundaram H. Aesthetic applications of calcium hydroxylapatite volumizing filler: an evidence-based review and discussion of current concepts (part 1 of 2). J Drugs Dermatol. 2013;12(12):1345–54.PubMed
32.
Zurück zum Zitat Sadick NS. A 52-week study of safety and efficacy of calcium hydroxylapatite for rejuvenation of the aging hand. J Drugs Dermatol. 2011;10(1):47–51.PubMed Sadick NS. A 52-week study of safety and efficacy of calcium hydroxylapatite for rejuvenation of the aging hand. J Drugs Dermatol. 2011;10(1):47–51.PubMed
33.
Zurück zum Zitat Marmur ES, Al Quran H, De Sa Earp AP, Yoo JY. A five-patient satisfaction pilot study of calcium hydroxylapatite injection for treatment of aging hands. Dermatol Surg. 2009;35(12):1978–84.PubMedCrossRef Marmur ES, Al Quran H, De Sa Earp AP, Yoo JY. A five-patient satisfaction pilot study of calcium hydroxylapatite injection for treatment of aging hands. Dermatol Surg. 2009;35(12):1978–84.PubMedCrossRef
35.
Zurück zum Zitat Weiss RA. Autologous cell therapy: will it replace dermal fillers? Facial Plast Surg Clin N Am. 2013;21(2):299–304.CrossRef Weiss RA. Autologous cell therapy: will it replace dermal fillers? Facial Plast Surg Clin N Am. 2013;21(2):299–304.CrossRef
36.
Zurück zum Zitat Smith SR, Munavalli G, Weiss R, Maslowski JM, Hennegan KP, Novak JM. A multicenter, double-blind, placebo controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles. Dermatol Surg. 2012;38(7 Pt 2):1234–43.PubMedCrossRef Smith SR, Munavalli G, Weiss R, Maslowski JM, Hennegan KP, Novak JM. A multicenter, double-blind, placebo controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles. Dermatol Surg. 2012;38(7 Pt 2):1234–43.PubMedCrossRef
37.
Zurück zum Zitat Weiss RA, Weiss MA, Beasley KL, Munavalli G. Autologous cultured fibroblast injection for facial contour deformities: a prospective, placebo-controlled, phase III clinical trial. Dermatol Surg. 2007;33(3):263–8.PubMed Weiss RA, Weiss MA, Beasley KL, Munavalli G. Autologous cultured fibroblast injection for facial contour deformities: a prospective, placebo-controlled, phase III clinical trial. Dermatol Surg. 2007;33(3):263–8.PubMed
39.
Zurück zum Zitat Kablik J, Monheit GD, Yu L, et al. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009;35:S302–12.CrossRef Kablik J, Monheit GD, Yu L, et al. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009;35:S302–12.CrossRef
40.
Zurück zum Zitat Sundaram H, Voigts B, Beer K, Meland M. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg. 2010;36:1859–65.PubMedCrossRef Sundaram H, Voigts B, Beer K, Meland M. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg. 2010;36:1859–65.PubMedCrossRef
41.
Zurück zum Zitat Edsman K, Nord LI, Ohrlund A, Lärkner H, Kenne AH. Gel properties of hyaluronic acid dermal fillers. Dermatol Surg. 2012;38(7 Pt 2):1170–9.PubMedCrossRef Edsman K, Nord LI, Ohrlund A, Lärkner H, Kenne AH. Gel properties of hyaluronic acid dermal fillers. Dermatol Surg. 2012;38(7 Pt 2):1170–9.PubMedCrossRef
42.
Zurück zum Zitat Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008;10:35–42.PubMedCrossRef Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008;10:35–42.PubMedCrossRef
43.
Zurück zum Zitat Flynn TC, Sarazin D, Bezzola A, Terrani C, Micheels P. Comparative histology of intradermal implantation of mono and biphasic hyaluronic acid fillers. Dermatol Surg. 2011;37(5):637–43.PubMedCrossRef Flynn TC, Sarazin D, Bezzola A, Terrani C, Micheels P. Comparative histology of intradermal implantation of mono and biphasic hyaluronic acid fillers. Dermatol Surg. 2011;37(5):637–43.PubMedCrossRef
44.
Zurück zum Zitat Cohen JL, Dayan SH, Brandt FS, Nelson DB, Axford-Gatley RA, Theisen MJ, Narins RS. Systematic review of clinical trials of small- and large-gel-particle hyaluronic acid injectable fillers for aesthetic soft tissue augmentation. Dermatol Surg. 2013;39(2):205–31.PubMedCrossRef Cohen JL, Dayan SH, Brandt FS, Nelson DB, Axford-Gatley RA, Theisen MJ, Narins RS. Systematic review of clinical trials of small- and large-gel-particle hyaluronic acid injectable fillers for aesthetic soft tissue augmentation. Dermatol Surg. 2013;39(2):205–31.PubMedCrossRef
46.
Zurück zum Zitat Narins RS, Coleman WP III, Donofrio LM, et al. Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial. Dermatol Surg. 2010;36(Suppl 3):1800–8.PubMedCrossRef Narins RS, Coleman WP III, Donofrio LM, et al. Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial. Dermatol Surg. 2010;36(Suppl 3):1800–8.PubMedCrossRef
47.
Zurück zum Zitat Kühne U, Imhof M, Kirchmeir M, Howell DJ. Five-year retrospective review of safety, injected volumes, and longevity of the hyaluronic acid Belotero Basic for facial treatments in 317 patients. J Drugs Dermatol. 2012;11:1032–5.PubMed Kühne U, Imhof M, Kirchmeir M, Howell DJ. Five-year retrospective review of safety, injected volumes, and longevity of the hyaluronic acid Belotero Basic for facial treatments in 317 patients. J Drugs Dermatol. 2012;11:1032–5.PubMed
48.
Zurück zum Zitat Downie JB, Grimes PE, Callender VD. A multicenter study of the safety and effectiveness of hyaluronic acid with a cohesive polydensified matrix for treatment of nasolabial folds in subjects with Fitzpatrick skin types IV, V, and VI. Plast Reconstr Surg. 2013;132(4 Suppl 2):41S–7S.PubMedCrossRef Downie JB, Grimes PE, Callender VD. A multicenter study of the safety and effectiveness of hyaluronic acid with a cohesive polydensified matrix for treatment of nasolabial folds in subjects with Fitzpatrick skin types IV, V, and VI. Plast Reconstr Surg. 2013;132(4 Suppl 2):41S–7S.PubMedCrossRef
49.
Zurück zum Zitat Goh AS, Kohn JC, Rootman DB, Lin JL, Goldberg RA. Hyaluronic acid gel distribution pattern in periocular area with high-resolution ultrasound imaging. Aesthet Surg J. 2014;34(4):510–5.PubMedCrossRef Goh AS, Kohn JC, Rootman DB, Lin JL, Goldberg RA. Hyaluronic acid gel distribution pattern in periocular area with high-resolution ultrasound imaging. Aesthet Surg J. 2014;34(4):510–5.PubMedCrossRef
50.
Zurück zum Zitat Prager W, Wissmueller E, Havermann I, et al. A prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial folds. Dermatol Surg. 2012;38(7 Pt 2):1143–50.PubMedCrossRef Prager W, Wissmueller E, Havermann I, et al. A prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial folds. Dermatol Surg. 2012;38(7 Pt 2):1143–50.PubMedCrossRef
51.
Zurück zum Zitat Lorenc ZP, Fagien S, Flynn TC, Waldorf HA. Review of key Belotero Balance safety and efficacy trials. Plast Reconstr Surg. 2013;132(4 Suppl 2):33S–40S.PubMedCrossRef Lorenc ZP, Fagien S, Flynn TC, Waldorf HA. Review of key Belotero Balance safety and efficacy trials. Plast Reconstr Surg. 2013;132(4 Suppl 2):33S–40S.PubMedCrossRef
52.
Zurück zum Zitat Sundaram H, Cassuto D. Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications. Plast Reconstr Surg. 2013;132(4 Suppl 2):5S–21S.PubMedCrossRef Sundaram H, Cassuto D. Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications. Plast Reconstr Surg. 2013;132(4 Suppl 2):5S–21S.PubMedCrossRef
53.
Zurück zum Zitat Lorenc ZR, Fagien S, Flynn TC, Waldorf HA. Clinical application and assessment of Belotero: a roundtable discussion. Plast Reconstr Surg. 2013;132(4S-2):69S–76S.PubMedCrossRef Lorenc ZR, Fagien S, Flynn TC, Waldorf HA. Clinical application and assessment of Belotero: a roundtable discussion. Plast Reconstr Surg. 2013;132(4S-2):69S–76S.PubMedCrossRef
54.
Zurück zum Zitat Jones D, Murphy DK. Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013;39(11):1602–12.PubMedCrossRef Jones D, Murphy DK. Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013;39(11):1602–12.PubMedCrossRef
55.
Zurück zum Zitat Carruthers J, Carruthers A, Tezel A, Kraemer J, Craik L. Volumizing with a 20-mg/mL smooth, highly cohesive, viscous hyaluronic acid filler and its role in facial rejuvenation therapy. Dermatol Surg. 2010;36(Suppl 3):1886–92.PubMedCrossRef Carruthers J, Carruthers A, Tezel A, Kraemer J, Craik L. Volumizing with a 20-mg/mL smooth, highly cohesive, viscous hyaluronic acid filler and its role in facial rejuvenation therapy. Dermatol Surg. 2010;36(Suppl 3):1886–92.PubMedCrossRef
57.
Zurück zum Zitat Raspaldo H. Volumizing effect of a new hyaluronic acid sub-dermal facial filler: a retrospective analysis based on 102 cases. J Cosmet Laser Ther. 2008;10(3):134–42.PubMedCrossRef Raspaldo H. Volumizing effect of a new hyaluronic acid sub-dermal facial filler: a retrospective analysis based on 102 cases. J Cosmet Laser Ther. 2008;10(3):134–42.PubMedCrossRef
58.
Zurück zum Zitat Philipp-Dormston WG, Eccleston D, De Boulle K, Hilton S, van den Elzen H, Nathan M. A prospective, observational study of the volumizing effect of open-label aesthetic use of Juvéderm® Voluma® with lidocaine in mid-face area. J Cosmet Laser Ther. 2014;16(4):171–9.PubMedCrossRef Philipp-Dormston WG, Eccleston D, De Boulle K, Hilton S, van den Elzen H, Nathan M. A prospective, observational study of the volumizing effect of open-label aesthetic use of Juvéderm® Voluma® with lidocaine in mid-face area. J Cosmet Laser Ther. 2014;16(4):171–9.PubMedCrossRef
60.
Zurück zum Zitat Micheels P, Sarazin D, Besse S, Sundaram H, Flynn TC. A blanching technique for intradermal injection of hyaluronic acid Belotero. Plast Reconstr Surg. 2013;132(4 Suppl 2):59S–68S.PubMedCrossRef Micheels P, Sarazin D, Besse S, Sundaram H, Flynn TC. A blanching technique for intradermal injection of hyaluronic acid Belotero. Plast Reconstr Surg. 2013;132(4 Suppl 2):59S–68S.PubMedCrossRef
61.
Zurück zum Zitat Ballin AC, Cazzaniga A, Brandt FS. Long-term efficacy, safety and durability of Juvéderm® XC. Clin Cosmet Investig Dermatol. 2013;6:183–9.PubMedCentralPubMed Ballin AC, Cazzaniga A, Brandt FS. Long-term efficacy, safety and durability of Juvéderm® XC. Clin Cosmet Investig Dermatol. 2013;6:183–9.PubMedCentralPubMed
62.
Zurück zum Zitat Levy PM, Boulle K, Raspaldo H. Comparison of injection comfort of a new category of cohesive hyaluronic acid filler with preincorporated lidocaine and a hyaluronic acid filler alone. Dermatol Surg. 2009;35:332–7.PubMedCrossRef Levy PM, Boulle K, Raspaldo H. Comparison of injection comfort of a new category of cohesive hyaluronic acid filler with preincorporated lidocaine and a hyaluronic acid filler alone. Dermatol Surg. 2009;35:332–7.PubMedCrossRef
63.
Zurück zum Zitat Weinkle SH, Bank DE, Boyd CM, Gold MH, Thomas JA, Murphy DK. A multi-center, double-blind, randomized controlled study of the safety and effectiveness of Juvéderm injectable gel with and without lidocaine. J Cosmet Dermatol. 2009;8(3):205–10.PubMedCrossRef Weinkle SH, Bank DE, Boyd CM, Gold MH, Thomas JA, Murphy DK. A multi-center, double-blind, randomized controlled study of the safety and effectiveness of Juvéderm injectable gel with and without lidocaine. J Cosmet Dermatol. 2009;8(3):205–10.PubMedCrossRef
64.
Zurück zum Zitat Marmur E, Green L, Busso M. Controlled, randomized study of pain levels in subjects treated with calcium hydroxylapatite premixed with lidocaine for correction of nasolabial folds. Dermatol Surg. 2010;36(3):309–15.PubMedCrossRef Marmur E, Green L, Busso M. Controlled, randomized study of pain levels in subjects treated with calcium hydroxylapatite premixed with lidocaine for correction of nasolabial folds. Dermatol Surg. 2010;36(3):309–15.PubMedCrossRef
65.
Zurück zum Zitat Tetzlaff JE. The pharmacology of local anesthetics. Anesthesiol Clin N Am. 2000;18(2):217–33.CrossRef Tetzlaff JE. The pharmacology of local anesthetics. Anesthesiol Clin N Am. 2000;18(2):217–33.CrossRef
66.
Zurück zum Zitat Busso M, Voigts R. An investigation of changes in physical properties of injectable calcium hydroxylapatite in a carrier gel when mixed with lidocaine and with lidocaine/epinephrine. Dermatol Surg. 2008;34(Suppl 1):S16–24.PubMed Busso M, Voigts R. An investigation of changes in physical properties of injectable calcium hydroxylapatite in a carrier gel when mixed with lidocaine and with lidocaine/epinephrine. Dermatol Surg. 2008;34(Suppl 1):S16–24.PubMed
67.
Zurück zum Zitat Hesxel D, Soirefmann M, Porto MD, Siega C, Souza JS, Brum C. Double-blind, randomized, controlled clinical trial to compare safety and efficacy of a metallic cannula with that of a standard needle for soft tissue augmentation of the nasolabial folds. Dermatol Surg. 2012;38(2):207–14. Hesxel D, Soirefmann M, Porto MD, Siega C, Souza JS, Brum C. Double-blind, randomized, controlled clinical trial to compare safety and efficacy of a metallic cannula with that of a standard needle for soft tissue augmentation of the nasolabial folds. Dermatol Surg. 2012;38(2):207–14.
Metadaten
Titel
Dermal Fillers: An Update
verfasst von
Annelyse Cristine Ballin
Fredric S. Brandt
Alex Cazzaniga
Publikationsdatum
01.08.2015
Verlag
Springer International Publishing
Erschienen in
American Journal of Clinical Dermatology / Ausgabe 4/2015
Print ISSN: 1175-0561
Elektronische ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-015-0135-7

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