Skip to main content
Erschienen in: Applied Health Economics and Health Policy 2/2014

01.04.2014 | Original Research Article

Variation in the Spillover Effects of Illness on Parents, Spouses, and Children of the Chronically Ill

verfasst von: Tara A. Lavelle, Eve Wittenberg, Kara Lamarand, Lisa A. Prosser

Erschienen in: Applied Health Economics and Health Policy | Ausgabe 2/2014

Einloggen, um Zugang zu erhalten

Abstract

Background

Given the broad scope of the spillover effects of illness, it is important to characterize the variability in these outcomes to identify relationship types in which secondary impacts of illness are particularly important to include in health economic evaluations.

Purpose

To examine heterogeneity in spillover effects of chronic conditions on family members by type of familial relationship with patient.

Methods

Adults (aged ≥18 years) and adolescents (aged 13–17 years) who had a parent, spouse, or child in their household with a chronic condition (Alzheimer’s disease/dementia, arthritis, cancer, or depression) were recruited from a US national panel to participate in an on-line survey. Respondents were asked to rate the spillover effect of their family member’s illness on their own health on a 0–100 scale, with lower scores indicating greater spillover. Regression analysis was used to evaluate the association between rating scale scores and relationship with an ill family member (ill parent, child, or spouse) for each illness separately, controlling for caregiving responsibility and the health status of the ill family member.

Results

1,267 adults and 102 adolescents met inclusion criteria. In adjusted analyses, having a sick child was significantly (p < 0.05) associated with lower rating scale scores compared with having a spouse with the same condition (cancer: −24.2; depression −9.7). Having a non-elderly or elderly adult parent with a condition, compared with a spouse, was significantly associated with lower rating scale scores for arthritis (−3.8) and depression (−5.3), but not for Alzheimer’s disease/dementia or cancer.

Conclusions

The impact of illness on family members, measured with a rating scale, varies by relationship type for certain illnesses. Having a child with cancer, a parent with arthritis, or either with depression, is significantly associated with greater spillover, compared with having a spouse with one of these conditions.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Wittenberg E, Prosser LA. Disutility of illness for caregivers and families: a systematic review of the literature. Pharmacoeconomics. 2013;31(6):489–500.PubMedCrossRef Wittenberg E, Prosser LA. Disutility of illness for caregivers and families: a systematic review of the literature. Pharmacoeconomics. 2013;31(6):489–500.PubMedCrossRef
2.
Zurück zum Zitat Bobinac A, van Exel NJ, Rutten FF, Brouwer WB. Caring for and caring about: disentangling the caregiver effect and the family effect. J Health Econ. 2010;29(4):549–56.PubMedCrossRef Bobinac A, van Exel NJ, Rutten FF, Brouwer WB. Caring for and caring about: disentangling the caregiver effect and the family effect. J Health Econ. 2010;29(4):549–56.PubMedCrossRef
3.
Zurück zum Zitat Bobinac A, van Exel NJ, Rutten FF, Brouwer WB. Health effects in significant others: separating family and care-giving effects. Med Decis Mak. 2011;31(2):292–8.CrossRef Bobinac A, van Exel NJ, Rutten FF, Brouwer WB. Health effects in significant others: separating family and care-giving effects. Med Decis Mak. 2011;31(2):292–8.CrossRef
4.
Zurück zum Zitat Brouwer WB. Too important to ignore: informal caregivers and other significant others. Pharmacoeconomics. 2006;24(1):39–41.PubMedCrossRef Brouwer WB. Too important to ignore: informal caregivers and other significant others. Pharmacoeconomics. 2006;24(1):39–41.PubMedCrossRef
5.
Zurück zum Zitat Brouwer WBF. Incorporating caregiver and family effects in economic evaluations of child health. In: Ungar WJ, editor. Economic evaluation in child health. Oxford: Oxford University Press; 2010. p. 55–76. Brouwer WBF. Incorporating caregiver and family effects in economic evaluations of child health. In: Ungar WJ, editor. Economic evaluation in child health. Oxford: Oxford University Press; 2010. p. 55–76.
6.
Zurück zum Zitat Wittenberg E, Ritter GA, Prosser LA. Evidence of spillover of illness among household members: EQ-5D scores from a US sample. Med Decis Mak. 2013;33(2):235–43.CrossRef Wittenberg E, Ritter GA, Prosser LA. Evidence of spillover of illness among household members: EQ-5D scores from a US sample. Med Decis Mak. 2013;33(2):235–43.CrossRef
7.
Zurück zum Zitat Basu A, Dale W, Elstein A, Meltzer D. A time tradeoff method for eliciting partner’s quality of life due to patient’s health states in prostate cancer. Med Decis Mak. 2010;30(3):355–65.CrossRef Basu A, Dale W, Elstein A, Meltzer D. A time tradeoff method for eliciting partner’s quality of life due to patient’s health states in prostate cancer. Med Decis Mak. 2010;30(3):355–65.CrossRef
8.
Zurück zum Zitat Basu A, Meltzer D. Implications of spillover effects within the family for medical cost-effectiveness analysis. J Health Econ. 2005;24(4):751–73.PubMedCrossRef Basu A, Meltzer D. Implications of spillover effects within the family for medical cost-effectiveness analysis. J Health Econ. 2005;24(4):751–73.PubMedCrossRef
9.
Zurück zum Zitat Poley MJ, Brouwer WBF, van Exel NJA, Tibboel D. Assessing health-related quality-of-life changes in informal caregivers: an evaluation in parents of children with major congenital anomalies. Qual Life Res. 2012;21(5):849–61.PubMedCentralPubMedCrossRef Poley MJ, Brouwer WBF, van Exel NJA, Tibboel D. Assessing health-related quality-of-life changes in informal caregivers: an evaluation in parents of children with major congenital anomalies. Qual Life Res. 2012;21(5):849–61.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Brouwer WBF, van Exel NJ, Van De Berg B, Dinant HJ, Koopmanschap MA, van den Bos GAM. Burden of caregiving: evidence of objective burden, subjective burden, and quality of life impacts on informal caregivers of patients with rheumatoid arthritis. Arthritis Rheum. 2004;51(4):570–7.PubMedCrossRef Brouwer WBF, van Exel NJ, Van De Berg B, Dinant HJ, Koopmanschap MA, van den Bos GAM. Burden of caregiving: evidence of objective burden, subjective burden, and quality of life impacts on informal caregivers of patients with rheumatoid arthritis. Arthritis Rheum. 2004;51(4):570–7.PubMedCrossRef
11.
Zurück zum Zitat Neumann PJ, Kuntz KM, Leon J, Araki SS, Hermann RC, Hsu MA, et al. Health utilities in Alzheimer’s disease: a cross-sectional study of patients and caregivers. Med Care. 1999;37(1):27–32.PubMedCrossRef Neumann PJ, Kuntz KM, Leon J, Araki SS, Hermann RC, Hsu MA, et al. Health utilities in Alzheimer’s disease: a cross-sectional study of patients and caregivers. Med Care. 1999;37(1):27–32.PubMedCrossRef
12.
Zurück zum Zitat Davidson T, Krevers B, Levin LA. In pursuit of QALY weights for relatives: empirical estimates in relatives caring for older people. Eur J Health Econ. 2008;9(3):285–92.PubMedCrossRef Davidson T, Krevers B, Levin LA. In pursuit of QALY weights for relatives: empirical estimates in relatives caring for older people. Eur J Health Econ. 2008;9(3):285–92.PubMedCrossRef
13.
Zurück zum Zitat Argyriou AA, Karanasios P, Ifanti AA, Iconomou G, Assimakopoulos K, Makridou A, et al. Quality of life and emotional burden of primary caregivers: a case-control study of multiple sclerosis patients in Greece. Qual Life Res. 2011;20(10):1663–8.PubMedCrossRef Argyriou AA, Karanasios P, Ifanti AA, Iconomou G, Assimakopoulos K, Makridou A, et al. Quality of life and emotional burden of primary caregivers: a case-control study of multiple sclerosis patients in Greece. Qual Life Res. 2011;20(10):1663–8.PubMedCrossRef
14.
Zurück zum Zitat Brisson M, Senecal M, Drolet M, Mansi JA. Health-related quality of life lost to rotavirus-associated gastroenteritis in children and their parents: a Canadian prospective study. Pediatr Infect Dis J. 2010;29(1):73–5.PubMedCrossRef Brisson M, Senecal M, Drolet M, Mansi JA. Health-related quality of life lost to rotavirus-associated gastroenteritis in children and their parents: a Canadian prospective study. Pediatr Infect Dis J. 2010;29(1):73–5.PubMedCrossRef
15.
Zurück zum Zitat Dixon S, Walker M, Salek S. Incorporating carer effects into economic evaluation. Pharmacoeconomics. 2006;24(1):43–53.PubMedCrossRef Dixon S, Walker M, Salek S. Incorporating carer effects into economic evaluation. Pharmacoeconomics. 2006;24(1):43–53.PubMedCrossRef
16.
Zurück zum Zitat Kuhlthau K, Kahn R, Hill KS, Gnanasekaran S, Ettner SL. The well-being of parental caregivers of children with activity limitations. Matern Child Health J. 2010;14(2):155–63.PubMedCrossRef Kuhlthau K, Kahn R, Hill KS, Gnanasekaran S, Ettner SL. The well-being of parental caregivers of children with activity limitations. Matern Child Health J. 2010;14(2):155–63.PubMedCrossRef
17.
Zurück zum Zitat Mohide EA, Torrance GW, Streiner DL, Pringle DM, Gilbert R. Measuring the wellbeing of family caregivers using the time trade-off technique. J Clin Epidemiol. 1988;41(5):475–82.PubMedCrossRef Mohide EA, Torrance GW, Streiner DL, Pringle DM, Gilbert R. Measuring the wellbeing of family caregivers using the time trade-off technique. J Clin Epidemiol. 1988;41(5):475–82.PubMedCrossRef
18.
Zurück zum Zitat Serrano-Aguilar PG, Lopez-Bastida J, Yanes-Lopez V. Impact on health-related quality of life and perceived burden of informal caregivers of individuals with Alzheimer’s disease. Neuroepidemiology. 2006;27(3):136–42.PubMedCrossRef Serrano-Aguilar PG, Lopez-Bastida J, Yanes-Lopez V. Impact on health-related quality of life and perceived burden of informal caregivers of individuals with Alzheimer’s disease. Neuroepidemiology. 2006;27(3):136–42.PubMedCrossRef
19.
Zurück zum Zitat Tilford JM, Grosse SD, Robbins JM, Pyne JM, Cleves MA, Hobbs CA. Health state preference scores of children with spina bifida and their caregivers. Qual Life Res. 2005;14(4):1087–98.PubMedCrossRef Tilford JM, Grosse SD, Robbins JM, Pyne JM, Cleves MA, Hobbs CA. Health state preference scores of children with spina bifida and their caregivers. Qual Life Res. 2005;14(4):1087–98.PubMedCrossRef
20.
Zurück zum Zitat van Exel NJ, Koopmanschap MA, van den Berg B, Brouwer WB, van den Bos GA. Burden of informal caregiving for stroke patients: identification of caregivers at risk of adverse health effects. Cerebrovasc Dis. 2005;19(1):11–7.PubMedCrossRef van Exel NJ, Koopmanschap MA, van den Berg B, Brouwer WB, van den Bos GA. Burden of informal caregiving for stroke patients: identification of caregivers at risk of adverse health effects. Cerebrovasc Dis. 2005;19(1):11–7.PubMedCrossRef
21.
Zurück zum Zitat Lieberman MA, Fisher L. The impact of chronic illness on the health and well-being of family members. Gerontologist. 1995;35(1):94–102.PubMedCrossRef Lieberman MA, Fisher L. The impact of chronic illness on the health and well-being of family members. Gerontologist. 1995;35(1):94–102.PubMedCrossRef
22.
Zurück zum Zitat Bell CM, Araki SS, Neumann PJ. The association between caregiver burden and caregiver health-related quality of life in Alzheimer disease. Alzheimer Dis Assoc Disord. 2001;15(3):129–36.PubMedCrossRef Bell CM, Araki SS, Neumann PJ. The association between caregiver burden and caregiver health-related quality of life in Alzheimer disease. Alzheimer Dis Assoc Disord. 2001;15(3):129–36.PubMedCrossRef
25.
Zurück zum Zitat Efron B. Better bootstrap confidence-intervals. J Am Stat Assoc. 1987;82(397):171–85.CrossRef Efron B. Better bootstrap confidence-intervals. J Am Stat Assoc. 1987;82(397):171–85.CrossRef
26.
Zurück zum Zitat Akaike H. New look at statistical-model identification. IEEE Trans Automat Contr. 1974;19(6):716–23.CrossRef Akaike H. New look at statistical-model identification. IEEE Trans Automat Contr. 1974;19(6):716–23.CrossRef
27.
Zurück zum Zitat Gold MR. Cost-effectiveness in health and medicine. New York: Oxford University Press; 1996. Gold MR. Cost-effectiveness in health and medicine. New York: Oxford University Press; 1996.
28.
Zurück zum Zitat Robinson A, Dolan P, Williams A. Valuing health status using VAS and TTO: what lies behind the numbers? Soc Sci Med. 1997;45(8):1289–97.PubMedCrossRef Robinson A, Dolan P, Williams A. Valuing health status using VAS and TTO: what lies behind the numbers? Soc Sci Med. 1997;45(8):1289–97.PubMedCrossRef
29.
Zurück zum Zitat Glick H. Assessing quality-adjusted life years: economic evaluation in clinical trials. Oxford: Oxford University Press; 2007. p. 59–87. Glick H. Assessing quality-adjusted life years: economic evaluation in clinical trials. Oxford: Oxford University Press; 2007. p. 59–87.
30.
Zurück zum Zitat Wittenberg E, Saada A, Prosser LA. How illness affects family members: a qualitative interview survey. Patient. 2013;6(4):257–68.PubMedCrossRef Wittenberg E, Saada A, Prosser LA. How illness affects family members: a qualitative interview survey. Patient. 2013;6(4):257–68.PubMedCrossRef
31.
Zurück zum Zitat Eisenberg D, Freed GL, Davis MM, Singer D, Prosser LA. Valuing health at different ages: evidence from a nationally representative survey in the US. Appl Health Econ Health Policy. 2011;9(3):149–56.PubMedCrossRef Eisenberg D, Freed GL, Davis MM, Singer D, Prosser LA. Valuing health at different ages: evidence from a nationally representative survey in the US. Appl Health Econ Health Policy. 2011;9(3):149–56.PubMedCrossRef
32.
Zurück zum Zitat Lavelle TA, Meltzer MI, Gebremariam A, Lamarand K, Fiore AE, Prosser LA. Community-based values for 2009 pandemic influenza A H1N1 illnesses and vaccination-related adverse events. PLoS One. 2011;6(12):e27777.PubMedCentralPubMedCrossRef Lavelle TA, Meltzer MI, Gebremariam A, Lamarand K, Fiore AE, Prosser LA. Community-based values for 2009 pandemic influenza A H1N1 illnesses and vaccination-related adverse events. PLoS One. 2011;6(12):e27777.PubMedCentralPubMedCrossRef
33.
Zurück zum Zitat Pullenayegum EM, Tarride JE, Xie F, O’Reilly D. Calculating utility decrements associated with an adverse event: marginal Tobit and CLAD coefficients should be used with caution. Med Decis Mak. 2011;31(6):790–9.CrossRef Pullenayegum EM, Tarride JE, Xie F, O’Reilly D. Calculating utility decrements associated with an adverse event: marginal Tobit and CLAD coefficients should be used with caution. Med Decis Mak. 2011;31(6):790–9.CrossRef
34.
Zurück zum Zitat Pullenayegum EM, Tarride JE, Xie F, Goeree R, Gerstein HC, O’Reilly D. Analysis of health utility data when some subjects attain the upper bound of 1: are Tobit and CLAD models appropriate? Value Health. 2010;13(4):487–94.PubMedCrossRef Pullenayegum EM, Tarride JE, Xie F, Goeree R, Gerstein HC, O’Reilly D. Analysis of health utility data when some subjects attain the upper bound of 1: are Tobit and CLAD models appropriate? Value Health. 2010;13(4):487–94.PubMedCrossRef
35.
Zurück zum Zitat Brazier J, Ratcliffe J, Salomon JA, Tsuchiya A. Valuing health: measuring and valuing health benefits for economic evaluation. Oxford: Oxford University Press; 2007. p. 83–138. Brazier J, Ratcliffe J, Salomon JA, Tsuchiya A. Valuing health: measuring and valuing health benefits for economic evaluation. Oxford: Oxford University Press; 2007. p. 83–138.
Metadaten
Titel
Variation in the Spillover Effects of Illness on Parents, Spouses, and Children of the Chronically Ill
verfasst von
Tara A. Lavelle
Eve Wittenberg
Kara Lamarand
Lisa A. Prosser
Publikationsdatum
01.04.2014
Verlag
Springer International Publishing
Erschienen in
Applied Health Economics and Health Policy / Ausgabe 2/2014
Print ISSN: 1175-5652
Elektronische ISSN: 1179-1896
DOI
https://doi.org/10.1007/s40258-014-0079-8

Weitere Artikel der Ausgabe 2/2014

Applied Health Economics and Health Policy 2/2014 Zur Ausgabe