1 Erratum to: Appl Health Econ Health Policy (2014) 12:447–459 DOI 10.1007/s40258-014-0107-8

The authors have informed us regarding some errors in the original publication. It should read as below:

Page 447, Abstract, paragraph 4, lines 2–5

The text which previously read:

“generated an incremental 0.24 QALYs and £5,238 costs over a lifetime horizon, resulting in an incremental cost-effectiveness ratio of £21,906 per QALY gained”

Should read:

“generated an incremental 0.19 QALYs and £5,389 costs over a lifetime horizon, resulting in an incremental cost-effectiveness ratio of £28,383 per QALY gained”

Page 447, Key Points for Decision Makers, paragraph 2, lines 2–4

The text which previously read:

“was estimated to be £21,906 per quality-adjusted life-year gained”

Should read:

“was estimated to be £28,383 per quality-adjusted life-year gained”

Page 453, 3.1 Base-Case Results, paragraph 1, lines 2–5

The text which previously read:

“increase lifetime discounted costs by £5,238 for an additional 0.24 QALYs gained compared with usual care alone. This resulted in an incremental cost-effectiveness ratio (ICER) of £21,906 per QALY gained”

Should read:

“increase lifetime discounted costs by £5,389 for an additional 0.19 QALYs gained compared with usual care alone. This resulted in an incremental cost-effectiveness ratio (ICER) of £28,383 per QALY gained”

Page 454, Fig. 2

Figure 2 should read:

Page 454, 3.2 Sensitivity Analyses, paragraph 1, lines 5–6

The text which previously read:

“which was at least 5 % of the base-case value of the ICER (£21,906).”

Should read:

“which was at least 5 % of the base-case value of the ICER (£28,383).”

Page 454, 3.2 Sensitivity Analyses, paragraph 1, lines 14–16

The text which previously read:

“When considering variations in the key model inputs, the ICER remained below £30,000 per QALY gained.”

Should read:

“When considering variations in the key model inputs, the ICER remained mostly below or slightly above £30,000 per QALY gained. The greatest impact was observed varying the costs for partly controlled asthma, with an ICER of £35,449 per QALY gained using the upper bound.”

Page 454, 3.2 Sensitivity Analyses, paragraph 2, lines 3–5

The text which previously read:

“Approximately 98 % of iterations appear in the north-east quadrant of the cost-effectiveness plane”

Should read:

“Approximately 96 % of iterations appear in the north-east quadrant of the cost-effectiveness plane”

Page 454, 3.2 Sensitivity Analyses, paragraph 3, lines 4–5

The text which previously read:

“is 66 % at a willingness to pay of £30,000 per QALY gained and 45 % for a willingness to pay of £20,000”

Should read:

“is 52 % at a willingness to pay of £30,000 per QALY gained and 31 % for a willingness to pay of £20,000”

Page 454, 3.3 Scenario Analyses, paragraph 1, lines 2–3

The text which previously read:

“reduced the ICER by around £2,000 per QALY gained (from £21,906 to £19,764)”

Should read:

“reduced the ICER by around £2,000 per QALY gained (from £28,383 to £26,033)”

Page 454, 3.3 Scenario Analyses, paragraph 2, lines 3–4

The text which previously read:

“with ICERs of £31,726, £24,538 and £23,301 per QALY gained”

Should read:

“with ICERs of £35,122, £30,318 and £29,418 per QALY gained”

Page 455, Fig. 3

Figure 3 should read:

Page 456, Fig. 4

Figure 4 should read:

Page 456, Table 7

Table 7 should read:

 

QALYs gained

Controlled asthma

Partly controlled asthma

Uncontrolled asthma

Non-severe exacerbation

Severe exacerbation without hospitalisation

Severe exacerbation with hospitalisation

Total QALYs

Tiotropium + usual care

4.09

3.12

6.80

0.33

0.16

0.01

14.52

Usual care

3.84

2.62

7.17

0.46

0.23

0.01

14.33

Difference

0.25

0.50

−0.38

−0.13

−0.06

0.00

0.19

  1. QALYs quality-adjusted life-years

Page 457, Fig. 5

Figure 5 should read:

Page 457, Fig. 6

Figure 6 should read:

Page 458, Fig. 7

Figure 7 should read:

Page 458, paragraph 2, lines 15–20

The text which previously read:

“the addition of tiotropium generates 0.24 additional QALYs over a lifetime horizon for this patient group. The PSA demonstrated that there is only a very small degree of uncertainty around this utility gain; an average utility gain of 0.239 and credible interval of 0.237–0.241 was observed in the PSA.”

Should read:

“the addition of tiotropium generates 0.19 additional QALYs over a lifetime horizon for this patient group (credible interval: −0.02 to 0.41).”

Page 458, paragraph 3, lines 5–10

The text which previously read:

“the model was most sensitive to changes in the costs of the uncontrolled and partly controlled asthma control health states; none of these variations resulted in an ICER above £30,000. Furthermore, the PSA demonstrated a 66 % likelihood of the base-case ICER being below £30,000 per QALY gained”

Should read:

“the model was most sensitive to changes in the costs of the uncontrolled and partly controlled asthma control health states; these variations resulted in ICERs of £31,784 and £35,449 per QALY gained, respectively. Furthermore, the PSA demonstrated a 52 % likelihood of the base-case ICER being below £30,000 per QALY gained”

Page 458, 5 Conclusion, paragraph 1, lines 7–8

The text which previously read:

“with an ICER of £21,906 per QALY gained and a 66 % likelihood of cost effectiveness”

Should read:

“with an ICER of £28,383 per QALY gained and a 52 % likelihood of cost effectiveness”

Electronic supplementary material, page 2, Table 2

Table 2 should read:

Electronic supplementary material, page 3, Table 3

Table 3 should read:

Acknowledgements IMS Health, funded by Boehringer Ingelheim, conducted the original analyses; Adam Lloyd was the guarantor of the overall content. Carl Samuelsen, Mike Baldwin and Dirk Esser from Boehringer Ingelheim conducted the re-analysis, as outlined in this erratum. Professor Eric Bateman and Professor Ian Pavord provided expertise on the clinical aspects of this study. Dirk Esser is a full-time employee of Boehringer Ingelheim. Adam Lloyd is a full-time employee of IMS Health. Jenny Willson and Tania Krivasi are former full-time employees of IMS Health. Professor Eric Bateman is Emeritus Professor of Medicine at the University of Cape Town and received consulting fees or honoraria from Boehringer Ingelheim for the meetings connected with this study. Professor Ian Pavord is Professor of Respiratory Medicine at the University of Oxford and received consulting fees or honoraria from Boehringer Ingelheim for the meetings connected with this study. Medical writing assistance with this erratum was supported financially by Boehringer Ingelheim and provided by Lianne Young, BSc (Hons), at Complete HealthVizion under the authors’ conceptual direction and based on feedback from the authors.