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Clinical Drug Investigation

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01.01.2014 | Original Research Article

Apixaban, Dabigatran, and Rivaroxaban Versus Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation: A Cost-Effectiveness Analysis

verfasst von: Carla Rognoni, Monia Marchetti, Silvana Quaglini, Nicola Lucio Liberato

Erschienen in: Clinical Drug Investigation | Ausgabe 1/2014

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Abstract

Background and objective

Non-valvular atrial fibrillation (NVAF) increases the risk of systemic thromboembolic events; therefore, anticoagulant treatment with vitamin K antagonists is widely prescribed. Recently, new oral anticoagulants (NOAs) directly inhibiting thrombin (dabigatran) or factor Xa (rivaroxaban and apixaban) demonstrated their non-inferiority with respect to warfarin in reducing the thromboembolic risk. The aim of this study was to estimate the cost effectiveness of NOAs in an Italian setting.

Methods

A Markov decision model including ten health states and death was developed, and a 3-month Markov cycle and lifetime horizon were adopted. Transition probabilities and quality of life were estimated from three randomized trials and from additional reports in the literature. Analysis was performed in the context of the Italian National Health System. First- and second-order sensitivity analyses were made to test the robustness of the results. The mean European cost of dabigatran (€2.58/day) was assigned to each NOA.

Results

The incremental cost-utility ratio was below €25,000/quality-adjusted life-year (QALY) gained for each NOA and each CHADS₂ level, but differences among drugs were found. This result was sensitive to the time in (warfarin) therapeutic range and time horizon.

Conclusions

Our analysis suggests that NOAs are a cost-effective treatment for the prevention of stroke in patients with NVAF in the Italian healthcare setting.

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Titel: Apixaban, Dabigatran, and Rivaroxaban Versus Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation: A Cost-Effectiveness Analysis
verfasst von: Carla Rognoni
Monia Marchetti
Silvana Quaglini
Nicola Lucio Liberato
Publikationsdatum: 01.01.2014
Verlag: Springer International Publishing
Erschienen in: Clinical Drug Investigation / Ausgabe 1/2014
Print ISSN: 1173-2563
Elektronische ISSN: 1179-1918
DOI: https://doi.org/10.1007/s40261-013-0144-3

Springer Medizin

Abstract

Background and objective

Methods

Results

Conclusions

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