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Erschienen in: Clinical Pharmacokinetics 2/2016

01.02.2016 | Review Article

Challenges Associated with Route of Administration in Neonatal Drug Delivery

verfasst von: Matthew W. Linakis, Jessica K. Roberts, Anita C. Lala, Michael G. Spigarelli, Natalie J. Medlicott, David M. Reith, Robert M. Ward, Catherine M. T. Sherwin

Erschienen in: Clinical Pharmacokinetics | Ausgabe 2/2016

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Abstract

The administration of drugs to neonates poses significant challenges. The aim of this review was to provide insight into some of these challenges and resolutions that may be encountered with several of the most commonly used routes of administration and dosage forms in neonatal care, including oral, parenteral, transdermal, intrapulmonary, and rectal. Important considerations include fluctuations in stomach pH hours to years after birth, the logistics of setting up an intravenous infusion, the need for reduced particle size for aerosol delivery to the developing neonatal lung, and variation in perirectal venous drainage. Additionally, some of the recently developed technologies for use in neonatal care are described. While the understanding of neonatal drug delivery has advanced over the past several decades, there is still a deficiency of technologies and formulations developed specifically for this population.
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Metadaten
Titel
Challenges Associated with Route of Administration in Neonatal Drug Delivery
verfasst von
Matthew W. Linakis
Jessica K. Roberts
Anita C. Lala
Michael G. Spigarelli
Natalie J. Medlicott
David M. Reith
Robert M. Ward
Catherine M. T. Sherwin
Publikationsdatum
01.02.2016
Verlag
Springer International Publishing
Erschienen in
Clinical Pharmacokinetics / Ausgabe 2/2016
Print ISSN: 0312-5963
Elektronische ISSN: 1179-1926
DOI
https://doi.org/10.1007/s40262-015-0313-z

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