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Drug Safety
Erschienen in: Drug Safety 8/2013

01.08.2013 | Original Research Article

Is Maternal Use of Medicines during Pregnancy Associated with Deciduous Molar Hypomineralisation in the Offspring? A Prospective, Population-Based Study

verfasst von: Marlies E. C. Elfrink, Henriette A. Moll, Jessica C. Kiefte-de Jong, Hanan El Marroun, Vincent W. V. Jaddoe, Albert Hofman, Bruno H. Stricker, Jacob M. ten Cate, Jaap S. J. Veerkamp

Erschienen in: Drug Safety | Ausgabe 8/2013

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Abstract

Background

The effects of maternal use of medicines during pregnancy on tooth development has scarcely been studied; only negative effects of tetracycline on tooth germs are known (irreversible tooth discoloration and enamel hypoplasia).

Objective

The aim of this study was to investigate whether antibacterials and anti-allergic and anti-asthma medicines, being the most frequently used medicines during pregnancy, are associated with deciduous molar hypomineralisation (DMH) and, if so, which specific medicines.

Materials and Methods

To clarify this possible association, the participants of the Generation R Study, a population-based prospective cohort study from fetal life until young adulthood, were studied. Data on medicine use during pregnancy were retrieved from pharmacies. Clinical photographs of the second primary molars, which were scored for DMH, were taken with an intra-oral camera in 6,690 children (mean age 6.2 years, standard deviation [SD] ± 0.53; 49.9 % girls).

Results

During pregnancy, 20.3 % of the mothers used antibacterials, 12.3 % anti-asthma medicines and 5.4 % anti-allergic medicines. The prevalence of DMH was 9.0 % in the study group. There was no association between the use of anti-asthma medicines, anti-allergic medicines (odds ratio [OR]: 0.97 [95 % CI 0.61–1.54]; OR: 1.04 [0.54–2.03]) or antibacterials (OR: 0.73 [0.49–1.09]) during pregnancy and DMH (all p-values >0.05). The study had sufficient power (80 %) to detect significant associations.

Conclusion

Maternal use of antibacterials, anti-allergic medicines or anti-asthma medicines during pregnancy is not associated with the development of DMH in the offspring.
Literatur
1.
Tredwin CJ, Scully C, Bagan-Sebastian JV. Drug-induced disorders of teeth. J Dent Res. 2005;84(7):596–602.CrossRefPubMed
2.
Lyaruu DM, van Duin MA, Bervoets TJ, et al. Effects of actinomycin D on developing hamster molar tooth germs in vitro. Eur J Oral Sci. 1997;105(1):52–8.CrossRefPubMed
3.
Laisi S, Ess A, Sahlberg C, et al. Amoxicillin may cause molar incisor hypomineralization. J Dent Res. 2009;88(2):132–6.CrossRefPubMed
4.
Alaki SM, Burt BA, Garetz SL. The association between antibiotics usage in early childhood and early childhood caries. Pediatr Dent. 2009;31(1):31–7.PubMed
5.
Hong L, Levy SM, Warren JJ, et al. Association of amoxicillin use during early childhood with developmental tooth enamel defects. Arch Pediatr Adolesc Med. 2005;159(10):943–8.CrossRefPubMed
6.
7.
Whatling R, Fearne JM. Molar incisor hypomineralization: a study of aetiological factors in a group of UK children. Int J Paediatr Dent. 2008;18(3):155–62.CrossRefPubMed
8.
Wogelius P, Haubek D, Nechifor A, et al. Association between use of asthma drugs and prevalence of demarcated opacities in permanent first molars in 6-to-8-year-old Danish children. Comm Dent Oral Epidemiol. 2010;38(2):145–51.CrossRef
9.
10.
Weerheijm KL, Duggal M, Mejare I, et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent. 2003;4(3):110–3.PubMed
11.
Jasulaityte L, Weerheijm KL, Veerkamp JS. Prevalence of molar-incisor-hypomineralisation among children participating in the Dutch National Epidemiological Survey (2003). Eur Arch Paediatr Dent. 2008;9(4):218–23.CrossRefPubMed
12.
Elfrink ME, Schuller AA, Weerheijm KL, et al. Hypomineralized second primary molars: prevalence data in Dutch 5-year-olds. Caries Res. 2008;42(4):282–5.CrossRefPubMed
13.
Elfrink MEC, ten Cate JM, Jaddoe VW, et al. Deciduous molar hypomineralization and molar incisor hypomineralization. J Dent Res. 2012;91(6):551–5.CrossRefPubMed
14.
Li Y, Navia JM, Bian JY. Prevalence and distribution of developmental enamel defects in primary dentition of Chinese children 3–5 years old. Comm Dent Oral Epidemiol. 1995;23(2):72–9.CrossRef
15.
Aine L, Backstrom MC, Maki R, et al. Enamel defects in primary and permanent teeth of children born prematurely. J Oral Pathol Med. 2000;29(8):403–9.CrossRefPubMed
16.
Slayton RL, Warren JJ, Kanellis MJ, et al. Prevalence of enamel hypoplasia and isolated opacities in the primary dentition. Pediatr Dent. 2001;23(1):32–6.PubMed
17.
Ghanim AM, Morgan MV, Marino RJ, et al. Risk factors of hypomineralised second primary molars in a group of Iraqi schoolchildren. Eur Arch Paediatr Dent. 2012;13(3):111–8.CrossRefPubMed
18.
Beentjes VE, Weerheijm KL, Groen HJ. Factors involved in the aetiology of molar-incisor hypomineralisation (MIH). Eur J Paediatr Dent. 2002;3(1):9–13.PubMed
19.
Alaluusua S, Lukinmaa PL, Vartiainen T, et al. Polychlorinated dibenzo-p-dioxins and dibenzofurans via mother’ s milk may cause developmental defects in the child’s teeth. Environ Toxicol Pharmacol. 1996;1:193–7.CrossRefPubMed
20.
Ghanim A, Manton D, Bailey D, et al. Risk factors in the occurrence of molar-incisor hypomineralization amongst a group of Iraqi children. Int J Paediatr Dent. 2013;23(3):197–206.CrossRefPubMed
21.
Jalevik B, Noren JG. Enamel hypomineralization of permanent first molars: a morphological study and survey of possible aetiological factors. Int J Paediatr Dent. 2000;10(4):278–89.CrossRefPubMed
22.
Profitt W, Fields H. Contemporary orthodontics. 3rd ed. St Louis: Mosby; 2000.
23.
Jaddoe VW, Mackenbach JP, Moll HA, et al. The Generation R Study: design and cohort profile. Eur J Epidemiol. 2006;21(6):475–84.CrossRefPubMed
24.
Jaddoe VW, van Duijn CM, van der Heijden AJ, et al. The Generation R Study: design and cohort update 2010. Eur J Epidemiol. 2010;25(11):823–41.CrossRefPubMed
25.
Statistics Netherlands. Allochtonen in Nederland 2004. Voorburg/Heerlen; 2004.
26.
Statistics Netherlands. Standaard onderwijs indeling 2003. Voorburg/Heerlen; 2004.
27.
Elfrink MEC, Veerkamp JSJ, Aartman IHA, et al. Validity of scoring caries and primary molar hypomineralisation (DMH) on intraoral photographs. Eur Arch Paediatr Dent. 2009;10(Suppl. 1):5–10.CrossRefPubMed
28.
Sterne JA, White IR, Carlin JB, et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;338:b2393.CrossRefPubMed
29.
Demidenko E. Sample size determination for logistic regression revisited. Stat Med. 2007;26(18):3385–97.CrossRefPubMed
30.
Demidenko E. Sample size and optimal design for logistic regression with binary interaction. Stat Med. 2008;27(1):36–46.CrossRefPubMed
31.
32.
Demers P, Fraser D, Goldbloom RB, et al. Effects of tetracyclines on skeletal growth and dentition: a report by the Nutrition Committee of the Canadian Paediatric Society. Can Med Assoc J. 1968;99(17):849–54.PubMed
33.
Crider KS, Cleves MA, Reefhuis J, et al. Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Arch Pediatr Adolesc Med. 2009;163(11):978–85.CrossRefPubMed
34.
Lin S, Munsie JP, Herdt-Losavio ML, et al. Maternal asthma medication use and the risk of selected birth defects. Pediatrics. 2012;129(2):e317–24.CrossRefPubMed
35.
Alaluusua S. Aetiology of molar-incisor hypomineralisation: a systematic review. Eur Arch Paediatr Dent. 2010;11(2):53–8.CrossRefPubMed
36.
Jalevik B, Noren JG, Klingberg G, et al. Etiologic factors influencing the prevalence of demarcated opacities in permanent first molars in a group of Swedish children. Eur J Oral Sci. 2001;109(4):230–4.CrossRefPubMed
37.
Tapias-Ledesma MA, Jimenez R, Lamas F, et al. Factors associated with first molar dental enamel defects: a multivariate epidemiological approach. J Dent Child (Chic). 2003;70(3):215–20.
38.
Souza JF, Santos-Pinto L, Alaluusua S, et al. Effect of amoxicillin on developing enamel of rat molars in vivo. EAPD Conference, 2012 May 24–27, Strasbourg.
39.
Vahakangas K, Myllynen P. Drug transporters in the human blood-placental barrier. Br J Pharmacol. 2009;158(3):665–78.CrossRefPubMed
40.
Nilsen RM, Vollset SE, Gjessing HK, et al. Self-selection and bias in a large prospective pregnancy cohort in Norway. Paediatr Perinat Epidemiol. 2009;23(6):597–608.CrossRefPubMed
Metadaten
Titel
Is Maternal Use of Medicines during Pregnancy Associated with Deciduous Molar Hypomineralisation in the Offspring? A Prospective, Population-Based Study
verfasst von
Marlies E. C. Elfrink
Henriette A. Moll
Jessica C. Kiefte-de Jong
Hanan El Marroun
Vincent W. V. Jaddoe
Albert Hofman
Bruno H. Stricker
Jacob M. ten Cate
Jaap S. J. Veerkamp
Publikationsdatum
01.08.2013
Verlag
Springer International Publishing
Erschienen in
Drug Safety / Ausgabe 8/2013
Print ISSN: 0114-5916
Elektronische ISSN: 1179-1942
DOI
https://doi.org/10.1007/s40264-013-0078-y

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