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Drugs & Aging

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01.03.2014 | Review Article

Atypical Antipsychotic-Induced Metabolic Disturbances in the Elderly

verfasst von: Melanie Dawn Guenette, Araba Chintoh, Gary Remington, Margaret Hahn

Erschienen in: Drugs & Aging | Ausgabe 3/2014

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Abstract

The metabolic side effects of atypical antipsychotics (AAPs) have been widely studied in younger populations, but research investigating these sequelae in the elderly is lacking. This article reviews the available literature examining the use of AAPs in the elderly, evaluating their association with weight gain and changes in blood glucose and lipid parameters. We find a relative paucity of studies in this area; while some data highlight significant, collective changes in metabolic parameters, the majority suggests an apparent low vulnerability to these side effects. We conclude that the risk and clinical implications of unfavorable metabolic changes in the elderly being treated with AAP medications remain largely undetermined, and we caution against drawing firm conclusions based on the available data. The conflicting evidence leaves us recommending that metabolic monitoring be implemented, with regular follow-up as advocated in other populations.

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Titel: Atypical Antipsychotic-Induced Metabolic Disturbances in the Elderly
verfasst von: Melanie Dawn Guenette
Araba Chintoh
Gary Remington
Margaret Hahn
Publikationsdatum: 01.03.2014
Verlag: Springer International Publishing
Erschienen in: Drugs & Aging / Ausgabe 3/2014
Print ISSN: 1170-229X
Elektronische ISSN: 1179-1969
DOI: https://doi.org/10.1007/s40266-014-0152-x

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Atypical Antipsychotic-Induced Metabolic Disturbances in the Elderly

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