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01.05.2015 | Systematic Review

Quantifying the Placebo Effect in Psychological Outcomes of Exercise Training: A Meta-Analysis of Randomized Trials

verfasst von: Jacob B. Lindheimer, Patrick J. O’Connor, Rod K. Dishman

Erschienen in: Sports Medicine | Ausgabe 5/2015

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Abstract

Background

The placebo effect could account for some or all of the psychological benefits attributed to exercise training. The magnitude of the placebo effect in psychological outcomes of randomized controlled exercise training trials has not been quantified. The aim of this investigation was to estimate the magnitude of the population placebo effect in psychological outcomes from placebo conditions used in exercise training studies and compare it to the observed effect of exercise training.

Methods

Articles published before 1 July 2013 were located using Google Scholar, MEDLINE, PsycINFO, and The Cochrane Library. To be included in the analysis, studies were required to have (1) a design that randomly assigned participants to exercise training, placebo, and control conditions and (2) an assessment of a subjective (i.e., anxiety, depression, energy, fatigue) or an objective (i.e., cognitive) psychological outcome. Meta-analytic and multi-level modeling techniques were used to analyze effects from nine studies involving 661 participants. Hedges’ d effect sizes were calculated, and random effects models were used to estimate the overall magnitude of the placebo and exercise training effects.

Results

After adjusting for nesting effects, the placebo mean effect size was 0.20 (95 % confidence interval [CI] −0.02, 0.41) and the observed effect of exercise training was 0.37 (95 % CI 0.11, 0.63).

Conclusion

A small body of research suggests both that (1) the placebo effect is approximately half of the observed psychological benefits of exercise training and (2) there is an urgent need for creative research specifically aimed at better understanding the role of the placebo effect in the mental health consequences of exercise training.

Benedetti F. Placebo effects: understanding the mechanisms in health and disease. New York: Oxford University Press; 2009.

Enck P, Klosterhalfen S, Zipfel S. Novel study designs to investigate the placebo response. BMC Med Res Methodol. 2011;11:90.PubMedCentralPubMed

Benedetti F, Mayberg HS, Wager TD, et al. Neurobiological mechanisms of the placebo effect. J Neurosci. 2005;25(45):10390–402.PubMed

Pollo A, Carlino E, Benedetti F. Placebo mechanisms across different conditions: From the clinical setting to physical performance. Philos Trans R Soc Lond B Biol Sci. 2011;366(1572):1790–8.PubMedCentralPubMed

Beedie CJ, Foad AJ. The placebo effect in sports performance: a brief review. Sports Med. 2009;39:313–29.PubMed

Bérdi M, Köteles F, Szabó A, et al. Placebo effects in sport and exercise: a meta-analysis. Eur J Ment Health. 2011;6(2):196–212.

Szabo A. Acute psychological benefits of exercise: Reconsideration of the placebo effect. J Ment Health. 2013;22(5):449–55.PubMed

Hrobjartsson A, Gotzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med. 2001;344:1594–602.PubMed

Hrobjartsson A, Gotzsche PC. Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment. J Intern Med. 2004; 256:91–100.PubMed

10.

Hróbjartsson A, Gøtzsche PC. Placebo interventions for all clinical conditions. Cochrane Database Syst Rev. 2010;(1):CD003974.

11.

Ernst E, Resch KL. Concept of true and perceived placebo effects. BMJ. 1995;311:551–3.PubMedCentralPubMed

12.

Kienle GS, Kiene H. The powerful placebo effect: fact or fiction? J Clin Epidemiol. 1997;50(12):1311–8.PubMed

13.

Ojanen M. Can the true effects of exercise on psychological variables be separated from placebo effects? Int J Sport Psychol. 1994;25:63–80.

14.

Orne MT. On the social psychology of the psychological experiment: With particular reference to demand characteristics and their implications. Am Psychol. 1962;17:776–83.

15.

Campbell DT. Factors relevant to the validity of experiments in social settings. Psychol Bull. 1957;54:297–311.PubMed

16.

Campbell DT, Stanley JC. Experimental and quasi-experimental designs for research. Chicago: Rand McNally; 1963.

17.

Morgan WP, editor. Physical activity and mental health. Washington: Taylor & Francis; 1997.

18.

Bartley CA, Hay M, Bloch MH. Meta-analysis: aerobic exercise for the treatment of anxiety disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2013;45C:34–9.

19.

Conn VS. Anxiety outcomes after physical activity interventions. Nurs Res. 2010;59:224–31.PubMedCentralPubMed

20.

Herring MP, O’Connor PJ, Dishman RK. The effect of exercise training on anxiety symptoms among patients. Arch Intern Med. 2010;170:321–31.PubMed

21.

Kugler J, Seelbach H, Krüskemper GM. Effects of rehabilitation exercise programmes on anxiety and depression in coronary patients: a meta-analysis. Br J Clin Psychol. 1994;33:401–10.PubMed

22.

Long BC, Van Stavel R. Effects of exercise training on anxiety: a meta-analysis. J Appl Sport Psychol. 1995;7:167–89.

23.

Petruzzello SJ, Landers DM, Hatfield BD, et al. A meta-analysis on the anxiety-reducing effects of acute and chronic exercise. Outcomes and mechanisms. Sports Med. 1991;11:143–82.PubMed

24.

Schlicht W. Does physical exercise reduce anxious emotions? A meta-analysis. Anxiety Stress Coping. 1994;6:275–88.

25.

Wipfli BM, Rethorst CD, Landers DM. The anxiolytic effects of exercise: a meta-analysis of randomized trials and dose–response analysis. J Sport Exerc Psychol. 2008;30:392–410.PubMed

26.

Wegner M, Helmich I, Machado S, et al. Effects of exercise on anxiety and depression disorders: review of meta-analyses and neurobiological mechanisms. CNS Neurol Disord Drug Targets. 2014;13:1002–14.PubMed

27.

Angevaren M, Aufdemkampe G, Verhaar HJJ, et al. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment (review). Cochrane Libr. 2008;4:1–73.

28.

Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14(2):125–30.PubMed

29.

Etnier JL, Nowell PM, Landers DM, et al. A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res Rev. 2006;52(1):119–30.PubMed

30.

Etnier JL, Salazar W, Landers DM, et al. The influence of physical fitness and exercise upon cognitive functioning: a meta-analysis. J Sport Exerc Psychol. 1997;19:249–77.

31.

Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. 2004;85(10):1694–704.PubMed

32.

Smith PJ, Blumenthal JA, Hoffman BM, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010;72(3):239–52.PubMedCentralPubMed

33.

Bridle C, Spanjers K, Patel S, et al. Effect of exercise on depression severity in older people: systematic review and meta-analysis of randomised controlled trials. Br J Psychiatry. 2012;201(3):180–5.PubMed

34.

Cooney GM, Dwan K, Greig C, et al. Exercise for depression (review). Cochrane Database Syst Rev. 2013;9:CD004366.PubMed

35.

Craft LL, Landers DM. The effects of exercise on clinical depression and depression resulting from mental illness: a meta regression analysis. J Sport Exerc Psychol. 1998;20:339–57.

36.

Edmonds M, McGuire H, Price J. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2004;(3):CD003200.

37.

Edmonds M, McGuire H, Price JR. Exercise therapy for chronic fatigue syndrome. Cochrane Libr. 2013;8:1–19.

38.

Herring MP, Puetz TW, O’Connor PJ, et al. Effect of exercise training on depressive symptoms among patients with a chronic illness. Arch Intern Med. 2012;172:101–11.PubMed

39.

Krogh J, Nordentoft M, Sterne JA, et al. The effect of exercise in clinically depressed adults: systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry. 2011;72(4):529–38.PubMed

40.

Lawlor DA, Hopker SW. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ. 2001;322:1–8.

41.

Mead GE, Morley W, Campbell P, et al. Exercise for depression. Cochrane Database Syst Rev. 2009;(3):CD004366.

42.

Rethorst CD, Wipfli BM, Landers DM. The antidepressive effects of exercise: a meta-analysis of randomized controlled trials. Sports Med. 2009;39:491–511.PubMed

43.

Rimer J, Dwan K, Lawlor DA, et al. Exercise for depression. Cochrane Database Sys Rev. 2012;(7):CD004366.

44.

Rutledge T, Reis VA, Linke SE, et al. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48(8):1527–37.PubMed

45.

Stathopoulou G, Powers MB, Berry AC, et al. Exercise interventions for mental health: a quantitative and qualitative review. Clin Psychol Sci Pract. 2006;13:179–93.

46.

Cooney G, Dwan K, Mead G. Exercise for depression. J Am Med Assoc Clin Evid Synop. 2014;311:2432–3.

47.

Kangas M, Bovbjerg DH, Montgomery GH. Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients. Psychol Bull. 2008;134:700–41.PubMed

48.

Buffart LM, van Uffelen JGZ, Riphagen II, et al. Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials. BMC Cancer. 2012;12:559.PubMedCentralPubMed

49.

Castell BD, Kazantzis N, Moss-Morris RE. Cognitive behavioral therapy and graded exercise for chronic fatigue syndrome: a meta-analysis. Clin Psychol Sci Pract. 2011;18:311–24.

50.

Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2012;(11):CD006145.

51.

Cramp F, Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2010;11:1–31.

52.

Jacobsen PB, Donovan KA, Vadaparampil ST, et al. Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue. Health Psychol. 2007;26(6):660–7.PubMedCentralPubMed

53.

McMillan EM, Newhouse IJ. Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis. Appl Physiol Nutr Metab. 2011;36(6):892–903.PubMed

54.

McNeely ML, Campbell KL, Rowe BH, et al. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. Can Med Assoc J. 2006;175(1):34–41.

55.

Pilutti LA, Greenlee TA, Motl RW, et al. Effects of exercise training on fatigue in multiple sclerosis: a meta-analysis. Psychosom Med. 2013;75(6):575–80.PubMed

56.

Puetz TW, Beasman KM, O’Connor PJ. The effect of cardiac rehabilitation exercise programs on feelings of energy and fatigue: a meta-analysis of research from 1945 to 2005. Eur J Cardiovasc Prev Rehabil. 2006;13(6):886–93.PubMed

57.

Puetz TW, Herring MP. Differential effects of exercise on cancer-related fatigue during and following treatment: a meta-analysis. Am J Prev Med. 2012;43(2):e1–24.PubMed

58.

Puetz TW, O’Connor PJ, Dishman RK. Effects of chronic exercise on feelings of energy and fatigue: a quantitative synthesis. Psychol Bull. 2006;132(6):866–76.PubMed

59.

Stevinson C, Lawlor DA, Fox KR. Exercise interventions for cancer patients: systematic review of controlled trials. Cancer Causes Control. 2004;15:1035–56.PubMed

60.

van Haren I, Timmerman H, Potting CM, et al. Physical exercise for patients undergoing hematopoietic stem cell transplantation: systematic review and meta-analyses of randomized controlled trials. Phys Ther. 2013;93:514–28.PubMed

61.

Velthuis MJ, Agasi-Idenburg SC, Aufdemkampe G, et al. The effect of physical exercise on cancer-related fatigue during cancer treatment: a meta-analysis of randomised controlled trials. Clin Oncol. 2010;22(3):208–21.

62.

Finniss DG, Kaptchuk TJ, Miller F, et al. Biological, clinical and ethical advances in placebo effects. Lancet. 2010;375:686–95.PubMedCentralPubMed

63.

Walach H, Maidhof C. Is the placebo effect dependent on time? A meta-analysis How expectancies shape experience. Washington: American Psychological Association; 1999.

64.

Price DD, Finniss DG, Benedetti F. A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol. 2008;59:565–90.PubMed

65.

Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e10000097.

66.

Cho HJ, Hotopf M, Wessely S. The placebo response in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis. Psychosom Med. 2005;67(2):301–13.PubMed

67.

Enck P, Klosterhalfen S, Weimer K, et al. The placebo response in clinical trials: more questions than answers. Philos Trans R Soc Lond B Biol Sci. 2011;366(1572):1889–95.PubMedCentralPubMed

68.

Ito S. Placebo in clinical trials. Clin Pharmacol Ther. 2011;90(5):637–9.PubMed

69.

Price DD. Assessing placebo effects without placebo groups: an untapped possibility? Pain. 2001;90:201–3.PubMed

70.

Ross S, Krugman AD, Lyerly SB, et al. Drugs and placebos: a model design. Psychol Rep. 1962;10:383–92.

71.

Wolf S. The pharmacology of placebos. Pharm Rev. 1959;11:689–704.PubMed

72.

Fassler M, Gnadinger M, Rosemann T, et al. Use of placebo interventions among Swiss primary care providers. BMC Health Serv Res. 2009;9:144.PubMedCentralPubMed

73.

Moses J, Steptoe A, Mathews A, et al. The effects of exercise training on mental well-being in the normal population: a controlled trial. J Psychosom Res. 1989;33:47–61.PubMed

74.

Steptoe A, Moses J, Mathews A, et al. Aerobic fitness, physical activity, and psychophysiological reactions to mental tasks. Psychophysiology. 1990;27:264–74.PubMed

75.

O’Connor PJ, Herring MP, Caravalho A. Mental health benefits of strength training in adults. Am J Lifestyle Med. 2010;4:377–96.

76.

Roth DL, Holmes DS. Influence of aerobic exercise training and relaxation training on physical and psychologic health following stressful life events. Psychosom Med. 1987;49:355–65.PubMed

77.

Williamson L, Wyatt MR, Yein K, et al. Severe knee osteoarthritis: a randomized controlled trial of acupuncture, physiotherapy (supervised exercise) and standard management for patients awaiting knee replacement. Rheumatology (Oxford). 2007;46:1445–9.

78.

White A, Foster NE, Cummings M, et al. Acupuncture treatment for chronic knee pain: a systematic review. Rheumatology (Oxford). 2007;46(3):384–90.

79.

Pilkington K, Kirkwood G, Rampes H, et al. Acupuncture for anxiety and anxiety disorders—a systematic literature review. Acupunct Med. 2007;25(1–2):1–10.PubMed

80.

Smith C, Hay P, MacPherson H. Acupuncture for depression. Cochrane Database Syst Rev. 2010;(1):CD004046.

81.

Medicine ACoS. ACSM’s resource manual for guidelines for exercise testing and prescription. 4th ed. Lippincott: Williams and Wilkins; 2001.

82.

Scherder EJ, Van Paasschen J, Deijen JB, et al. Physical activity and executive functions in the elderly with mild cognitive impairment. Aging Ment Health. 2005;9(3):272–80.PubMed

83.

Daley AJ, Crank H, Saxton JM, et al. Randomized trial of exercise therapy in women treated for breast cancer. J Clin Oncol. 2007;25(13):1713–21.PubMed

84.

McCann IL, Holmes DS. Influence of aerobic exercise on depression. J Pers Soc Psychol. 1984;46:1142–7.PubMed

85.

Beck AT, Steer RA, Garbin MG. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev. 1988;8:77–100.

86.

Tench CM, McCarthy J, McCurdie I, et al. Fatigue in systemic lupus erythematosus: A randomized controlled trial of exercise. Rheumatology (Oxford). 2003;42(9):1050–4.

87.

Hedges L, Olkin I. Statistical methods for meta-analysis. New York: Academic Press; 1985.

88.

Lipsey M, Wilson D. Practical meta-analysis. Thousand Oaks: Sage Publications; 2001.

89.

Rosenberg MS. The file-drawer problem revisited: a general weighted method for calculating fail-safe numbers in meta-analysis. Evolution. 2005;59:464–8.PubMed

90.

Muthén L, Muthén B. Mplus user’s guide. Los Angeles: Muthen & Muthen; 1998–2012.

91.

Cheung M. A model for integrating fixed-, random-, and mixed-effects meta-analyses into structural equation modeling. Psychol Methods. 2008;13:182–202.PubMed

92.

Hox J. Multilevel analysis: techniques and applications. In: Marcoulides G, editor, 2nd ed. New York: Routledge; 2010. p. 205–232.

93.

Froot K. Consistent covariance matrix estimation with cross-sectional dependence and heteroskedasticity in financial data. J Financ Quant Anal. 1989;24:333–55.

94.

White H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica. 1980;48:817–38.

95.

Williams R. A note on robust variance estimation for cluster-correlated data. Biometrics. 2000;56:645–6.PubMed

96.

Rosenthal R, DiMatteo MR. Meta-analysis: recent developments in quantitative methods for literature reviews. Annu Rev Psychol. 2001;52:59–82.PubMed

97.

Powell RR. Psychological effects of exercise therapy upon institutionalized geriatric mental patients. J Gerontol. 1974;29:157–61.PubMed

98.

McNeil JK, LeBlanc EM, Joyner M. The effect of exercise on depressive symptoms in the moderately depressed elderly. Psychol Aging. 1991;6:487–8.PubMed

99.

Brown AK, Liu-Ambrose T, Tate R, et al. The effect of group-based exercise on cognitive performance and mood in seniors residing in intermediate care and self-care retirement facilities: a randomised controlled trial. Br J Sports Med. 2009;43:608–14.PubMed

100.

Josefsson T, Lindwall M, Archer T. Physical exercise intervention in depressive disorders: meta-analysis and systematic review. Scand J Med Sci Sports. 2013;24:259–72.PubMed

101.

Kirsch I. Response expectancy theory and application: a decennial review. Appl Prev Psychol. 1997;6:69–79.

102.

Kirsch I. Response expectancy as a determinant of experience and behavior. Am Psychol. 1985;40:1189–202.

103.

Huedo-Medina TB, Kirsch I, Middlemass J, et al. Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration. BMJ. 2012;345:e8343.PubMedCentralPubMed

104.

Benedetti F, Colloca L, Torre E, et al. Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus. Nat Neurosci. 2004;7(6):587–8.PubMed

105.

de Craen AJM, Tijssen JGP, de Gans J, et al. Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos. J Neurol. 2000;247:183–8.PubMed

106.

Finniss DG, Kaptchuk TJ, Miller F, et al. Biological, clinical, and ethical advances of placebo effects. Lancet. 2010;375(9715):686–95.PubMedCentralPubMed

107.

Pomp S, Fleig L, Schwarzer R, et al. Depressive symptoms interfere with post-rehabilitation exercise: outcome expectancies and experience as mediators. Psychol Health Med. 2012;17(6):698–708.PubMed

108.

Stetler C. Adherence, expectations and the placebo response: why is good adherence to an inert treatment beneficial? Psychol Health. 2014;29(2):127–40.PubMed

109.

Bell HJ, Ramsaroop DM, Duffin J. The respiratory effects of two modes of passive exercise. Eur J Appl Physiol. 2003;88(6):544–52.PubMed

110.

Valli P, Boldrini D, Bianchedi D, et al. Effects of low intensity electrical stimulation on quadriceps muscle voluntary maximal strength. J Sports Med Phys Fit. 2002;42:425–30.

111.

Morgan WP, Raven PB, Drinkwater BL, et al. Perceptual and metabolic responsivity to standard bicycle ergometry following various hypnotic suggestions. Int J Clin Exp Hypn. 1973;21:86–101.

112.

Hausenblas HA, Hall CR, Rodgers WM, et al. Exercise imagery: its nature and measurement. J Appl Sport Psychol. 1999;11(2):171–80.

113.

Steinhardt MA, Dishman RK. Reliability and validity of expected outcomes and barriers for habitual physical activity. J Occup Med. 1989;31:536–46.PubMed

114.

Resnick B, Zimmerman SI, Orwig D, et al. Outcome expectations for exercise scale: utility and psychometrics. J Gerontol. 2000;55B:S352–6.

115.

Macedo LG, Bostick GP, Maher CG. Exercise for prevention of recurrences of nonspecific low pack pain. Phys Ther. 2013;93:1587–91.PubMed

116.

Jansen MJ, Viechtbauer W, Lenssen AF, et al. Strength training alone, exercise therapy alone, and exercise therapy with passive manual mobilisation each reduce pain and disability in people with knee osteoarthritis: a systematic review. J Physiother. 2011;57:11–20.PubMed

117.

Bennell KL, Hinman RS. A review of the clinical evidence for exercise in osteoarthritis of the hip and knee. J Sci Med Sport. 2011;14(1):4–9.PubMed

118.

van Middelkoop M, Rubinstein SM, Verhagen AP, et al. Exercise therapy for chronic nonspecific low-back pain. Best Pract Res Clin Rheumatol. 2010;24(2):193–204.PubMed

119.

Miller J, Gross A, D’Sylva J, et al. Manual therapy and exercise for neck pain: a systematic review. Man Ther. 2010;15:334–54.PubMed

120.

Lin CW, Taylor D, Bierma-Zeinstra SM, et al. Exercise for osteoarthritis of the knee. Phys Ther. 2010;90(6):839–42.PubMed

121.

Ferreira ML, Smeets RJ, Kamper SJ, et al. Can we explain heterogeneity among randomized clinical trials of exercise for chronic back pain? A meta-regression analysis of randomized controlled trials. Phys Ther. 2010;90(10):1383–403.PubMed

122.

Brosseau L, MacLeay L, Welch V, et al. Intensity of exercise for the treatment of osteoarthritis (review). Cochrane Libr. 2010;7:1–11.

123.

Waller B, Lambeck J, Daly D. Therapeutic aquatic exercise in the treatment of low back pain: a systematic review. Clin Rehabil. 2009;23:3–14.PubMed

124.

Fransen M, McConnell S, Hernandez-Molina G, et al. Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev. 2009;(3):CD007912.

125.

Fransen M, McConnell S. Exercise for osteoarthritis of the knee (review). Cochrane Libr. 2009;3:1–93.

126.

Bartels E, Lund H, Hagen K, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis (review). Cochrane Libr. 2009;1:1–36.

127.

Lee MS, Pittler MH, Ernst E. Tai chi for osteoarthritis: a systematic review. Clin Rheumatol. 2008;27:211–8.PubMed

128.

Hall J, Swinkels A, Briddon J, et al. Does aquatic exercise relieve pain in adults with neurologic or musculoskeletal disease? A systematic review and meta-analysis of randomized controlled trials. Arch Phys Med Rehabil. 2008;89(5):873–83.PubMed

129.

Wasielewski NJ, Kotsko KM. Does eccentric exercise reduce pain and improve strength in physically active adults with symptomatic lower extremity tendinosis? A systematic review. J Athl Train. 2007;42:409–21.PubMedCentralPubMed

130.

Hoffman MD, Hoffman DR. Does aerobic exercise improve pain perception and mood? A review of the evidence related to healthy and chronic pain subjects. Curr Pain Headache Rep. 2007;11:93–7.PubMed

131.

Ferreira PH, Ferreira ML, Maher CG, et al. Specific stabilisation exercise for spinal and pelvic pain: a systematic review. Aust J Physiother. 2006;52:79–88.PubMed

132.

Devos-Comby L, Cronan T, Roesch SC. Do exercise and self-management interventions benefit patients with osteoarthritis of the knee? A meta-analytic review. J Rheumatol. 2006;33:744–56.PubMed

133.

van Tulder MW, Malmivaara A, Esmail R, et al. Exercise therapy for low-back pain (review). Cochrane Libr. 2005;2:1–27.

134.

Hayden J, van Tulder MW, Malmivaara A, et al. Exercise therapy for treatment of non-specific low back pain (review). Cochrane Libr. 2011;3:1–100.

135.

Liddle SD, Baxter GD, Gracey JH. Exercise and chronic low back pain: what works? Pain. 2004;107:176–90.PubMed

136.

Kettunen JA, Kujala UM. Exercise therapy for people with rheumatoid arthritis and osteoarthritis. Scand J Med Sci Sports. 2004;14(3):138–42.PubMed

137.

van Tulder M, Malmivaara A, Esmail R, et al. Exercise therapy for low back pain. Spine (Phila Pa 1976). 2000;25:2784–96.

138.

Hilde G, Bo K. Effect of exercise in the treatment of chronic low back pain: A systematic review, emphasising type and dose of exercise. Phys Ther Rev. 1998;3:107–17.

139.

Ettinger WH, Afable RF. Physical disability from knee osteoarthritis: the role of exercise as an intervention. Med Sci Sports Exerc. 1994;26:1435–40.PubMed

140.

Dekker J, Mulder PH, Bijlsma JWJ, et al. Exercise therapy in patients with rheumatoid arthritis and osteoarthritis: a review. Adv Behav Res Ther. 1993;15:211–38.

141.

Faas A, Chavannes AW, van Eijkl JTM, et al. A randomized, placebo-controlled trial of exercise therapy in patients with acute low back back. Spine (Phila Pa 1976). 1993;18:1388–95.

142.

Rohsenow DJ, Marlatt GA. The balanced placebo design: methodological considerations. Addict Behav. 1981;6:107–22.PubMed

Titel: Quantifying the Placebo Effect in Psychological Outcomes of Exercise Training: A Meta-Analysis of Randomized Trials
verfasst von: Jacob B. Lindheimer
Patrick J. O’Connor
Rod K. Dishman
Publikationsdatum: 01.05.2015
Verlag: Springer International Publishing
Erschienen in: Sports Medicine / Ausgabe 5/2015
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI: https://doi.org/10.1007/s40279-015-0303-1

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Quantifying the Placebo Effect in Psychological Outcomes of Exercise Training: A Meta-Analysis of Randomized Trials

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