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Erschienen in: Sports Medicine 6/2021

29.04.2021 | Systematic Review

The Effect of Impact Exercise (Alone or Multicomponent Intervention) on Health-Related Outcomes in Individuals at Risk of Fractures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

verfasst von: Isabel B. Rodrigues, Matteo Ponzano, Zeinab Hosseini, Lehana Thabane, Philip D. Chilibeck, Debra A. Butt, Maureen C. Ashe, Jackie Stapleton, John Wark, Lora M. Giangregorio

Erschienen in: Sports Medicine | Ausgabe 6/2021

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Abstract

Background

Exercise is commonly recommended to prevent and manage osteoporosis. High magnitude strains at rapid rate and short bouts should theoretically elicit an osteogenic response; however, the effects of different levels of impact exercises on several outcomes in people at risk of fracture are still unknown.

Objective

To report the effect of impact exercise on falls, fractures, adverse events, mortality, bone mineral density (BMD), physical functioning, and health-related quality of life (QoL).

Methods

We included randomized controlled trials testing the effect of impact exercise compared with a non-exercise control on outcomes in adults ≥ 50 years with low BMD or fragility fractures. Two reviewers selected studies and extracted data. Where possible, we pooled outcomes using mean difference (MD) with a fixed-effects model and 95% confidence interval (CI). We reported risk of bias using Cochrane and certainty of evidence using GRADE.

Results

We included 29 trials; 19 studies evaluated impact exercise alone, and the remaining trials combined impact with resistance or balance training. Impact exercise alone or combined with resistance training improved Timed Up-and-Go values (MD − 0.95 s, 95% CI − 1.09 to − 0.81, low certainty evidence) and lumbar spine (MD 0.04 g/cm2, 95% CI 0.02–0.06, low certainty evidence) and femoral neck BMD (MD 0.04 g/cm2, 95% CI 0.02–0.07, low certainty evidence). Impact exercise did not improve health-related QoL assessed with QUALEFFO-41 (MD 0.06, 95% CI − 2.18 to 2.30, moderate certainty evidence). The effects of impact exercise on falls, fractures, and mortality are uncertain due to insufficient data. Many trials had a high risk of bias for two or more items.

Conclusions

There is low certainty evidence that impact exercise may improve physical function and BMD in people at risk of fracture. The effect of impact exercises on falls, fractures, and mortality remains unclear. Our findings should be interpreted with caution due to risk of bias and small sample sizes.

Trial Registration

Registered in Prospero (CRD42018115579) on January 30, 2019.
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Literatur
4.
Zurück zum Zitat Welsh L, Rutherford OM. Hip bone mineral density is improved by high-impact aerobic exercise in postmenopausal women and men over 50 years. Eur J Appl Physiol Occup Physiol. 1996;74(6):511–7.CrossRef Welsh L, Rutherford OM. Hip bone mineral density is improved by high-impact aerobic exercise in postmenopausal women and men over 50 years. Eur J Appl Physiol Occup Physiol. 1996;74(6):511–7.CrossRef
5.
Zurück zum Zitat Turner C, Robling A. Exercises for improving bone strength. BR J Sport Med. 2005;39(4):188–9.CrossRef Turner C, Robling A. Exercises for improving bone strength. BR J Sport Med. 2005;39(4):188–9.CrossRef
6.
Zurück zum Zitat Turner C, Robling A. Designing exercise regimens to increase bone strength. Exerc Sport Sci Rev. 2003;31(1):45–50.CrossRef Turner C, Robling A. Designing exercise regimens to increase bone strength. Exerc Sport Sci Rev. 2003;31(1):45–50.CrossRef
7.
Zurück zum Zitat Kohrt W, Barry D, Schwartz RS. Muscle forces or gravity: what predominates mechanical loading on bone? Med Sci Sport Exerc. 2011;41(11):2050–5.CrossRef Kohrt W, Barry D, Schwartz RS. Muscle forces or gravity: what predominates mechanical loading on bone? Med Sci Sport Exerc. 2011;41(11):2050–5.CrossRef
9.
Zurück zum Zitat Nikander R, Gagnon C, Dunstan D. Frequent walking, but not total physical activity, is associated with increased fracture incidence: a 5-year follow-up of an Australian population-based prospective study (AusDiab). J Bone Miner Res. 2011;25(7):1638–47.CrossRef Nikander R, Gagnon C, Dunstan D. Frequent walking, but not total physical activity, is associated with increased fracture incidence: a 5-year follow-up of an Australian population-based prospective study (AusDiab). J Bone Miner Res. 2011;25(7):1638–47.CrossRef
11.
Zurück zum Zitat Rodrigues IB, Ashe M, Bartley J. How exercise professionals support people with acute vertebral fractures? [abstract]. In: Proceedings of the 2019 American society of bone mineral research. 2019. Rodrigues IB, Ashe M, Bartley J. How exercise professionals support people with acute vertebral fractures? [abstract]. In: Proceedings of the 2019 American society of bone mineral research. 2019.
12.
Zurück zum Zitat Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLOS Med. 2009;8(5):336–41. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLOS Med. 2009;8(5):336–41.
13.
Zurück zum Zitat Higgins J, Altman D, Gotzsche P, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.CrossRef Higgins J, Altman D, Gotzsche P, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.CrossRef
14.
Zurück zum Zitat Rodrigues I, Ponzano M, Butt D, et al. The effects of walking or Nordic walking in adults 50 years and older at risk of fractures: a systematic review and meta-analysis. JAPA. 2020 (in press). Rodrigues I, Ponzano M, Butt D, et al. The effects of walking or Nordic walking in adults 50 years and older at risk of fractures: a systematic review and meta-analysis. JAPA. 2020 (in press).
15.
Zurück zum Zitat Ponzano M, Rodrigues I, Hosseini Z, et al. Progressive resistance training for improving health-related outcomes in people at risk of fracture: a systematic review and meta-analysis. Phys Ther. 2020 (in press). Ponzano M, Rodrigues I, Hosseini Z, et al. Progressive resistance training for improving health-related outcomes in people at risk of fracture: a systematic review and meta-analysis. Phys Ther. 2020 (in press).
17.
Zurück zum Zitat Marotti G. Map of bone formation rate values recorded throughout the skeleton of the dog. Bone Morphometry, University of Ottawa Press, Ottawa, Ontario. 1975. p. 202–07. Marotti G. Map of bone formation rate values recorded throughout the skeleton of the dog. Bone Morphometry, University of Ottawa Press, Ottawa, Ontario. 1975. p. 202–07.
18.
Zurück zum Zitat Kimmel B. A quantitative histologic study of bone turnover in young adult beagles. Anat Rec. 1982;45:31–45.CrossRef Kimmel B. A quantitative histologic study of bone turnover in young adult beagles. Anat Rec. 1982;45:31–45.CrossRef
20.
Zurück zum Zitat Lips P, Cooper C, Agnusdei D, et al. Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int. 1999;10(2):150–60.CrossRef Lips P, Cooper C, Agnusdei D, et al. Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int. 1999;10(2):150–60.CrossRef
22.
Zurück zum Zitat Alayat M, Abdel-Kafy E, Thabet A, et al. Long-term effect of pulsed Nd-YAG laser combined with exercise on bone mineral density in men with osteopenia or osteoporosis: 1 year of follow-up. Photomed Laser Surg. 2018;36(2):105–11.CrossRef Alayat M, Abdel-Kafy E, Thabet A, et al. Long-term effect of pulsed Nd-YAG laser combined with exercise on bone mineral density in men with osteopenia or osteoporosis: 1 year of follow-up. Photomed Laser Surg. 2018;36(2):105–11.CrossRef
23.
Zurück zum Zitat Basat H, Esmaeilzadeh S, Eskiyurt N. The effects of strengthening and high-impact exercises on bone metabolism and quality of life in postmenopausal women: a randomized controlled trial. J Back Musculoskelet Rehabil. 2013;26(4):427–35.CrossRef Basat H, Esmaeilzadeh S, Eskiyurt N. The effects of strengthening and high-impact exercises on bone metabolism and quality of life in postmenopausal women: a randomized controlled trial. J Back Musculoskelet Rehabil. 2013;26(4):427–35.CrossRef
24.
Zurück zum Zitat Bergland A, Thorsen H, Karesen R. Effect of exercise on mobility, balance, and health-related quality of life in osteoporotic women with a history of vertebral fracture: a randomized, controlled trial. Osteoporos Int. 2011;22(6):1863–71.CrossRef Bergland A, Thorsen H, Karesen R. Effect of exercise on mobility, balance, and health-related quality of life in osteoporotic women with a history of vertebral fracture: a randomized, controlled trial. Osteoporos Int. 2011;22(6):1863–71.CrossRef
26.
Zurück zum Zitat Borba-Pinheiro C, Dantas E, Drigo A, et al. Adapted combat sports on bone related variables and functional independence of postmenopausal women in pharmacological treatment: a clinical trial study. Arch Budo. 2016;12(1):187–99. Borba-Pinheiro C, Dantas E, Drigo A, et al. Adapted combat sports on bone related variables and functional independence of postmenopausal women in pharmacological treatment: a clinical trial study. Arch Budo. 2016;12(1):187–99.
28.
Zurück zum Zitat Chao M, Hazelton M, Cholowski K. The effect of an exercise program on physical fitness and quality of life in adults with osteopenia in Taiwan: a randomized controlled trial. Thai J Nurs Res. 2005;9(3):170–92. Chao M, Hazelton M, Cholowski K. The effect of an exercise program on physical fitness and quality of life in adults with osteopenia in Taiwan: a randomized controlled trial. Thai J Nurs Res. 2005;9(3):170–92.
29.
Zurück zum Zitat Cheng J, Haibing H, Chen Y. Effect of aerobic exercise and raloxifene combination therapy on senile osteoporosis. J Phys Ther Sci. 2016;28(6):1791–4.CrossRef Cheng J, Haibing H, Chen Y. Effect of aerobic exercise and raloxifene combination therapy on senile osteoporosis. J Phys Ther Sci. 2016;28(6):1791–4.CrossRef
30.
Zurück zum Zitat Chien M, Wu Y, Hsu A, et al. Efficacy of a 24-week aerobic exercise program for osteopenic postmenopausal women. Calcif Tissue Int. 2000;67(6):443–8.CrossRef Chien M, Wu Y, Hsu A, et al. Efficacy of a 24-week aerobic exercise program for osteopenic postmenopausal women. Calcif Tissue Int. 2000;67(6):443–8.CrossRef
31.
Zurück zum Zitat Fleisher L, Trudelle-Jackson M, Thompson E, et al. Effects of weight-bearing and resistance exercises on lower extremity strength, postural stability, and quality of life in postmenopausal women with low bone mass. J Womens Health Phys. 2011;35(3):114–27. Fleisher L, Trudelle-Jackson M, Thompson E, et al. Effects of weight-bearing and resistance exercises on lower extremity strength, postural stability, and quality of life in postmenopausal women with low bone mass. J Womens Health Phys. 2011;35(3):114–27.
32.
Zurück zum Zitat Iwamoto J, Takeda T, Otani T, et al. Effect of increased physical activity on bone mineral density in postmenopausal osteoporotic women. Keio J Med. 1998;47(3):157–61.CrossRef Iwamoto J, Takeda T, Otani T, et al. Effect of increased physical activity on bone mineral density in postmenopausal osteoporotic women. Keio J Med. 1998;47(3):157–61.CrossRef
34.
Zurück zum Zitat Jones G, Jakobi J, Taylor A. Community exercise program for older adults recovering from hip fracture: a pilot study. J Aging Phys Act. 2006;14(4):439–55.CrossRef Jones G, Jakobi J, Taylor A. Community exercise program for older adults recovering from hip fracture: a pilot study. J Aging Phys Act. 2006;14(4):439–55.CrossRef
35.
Zurück zum Zitat Korpelainen R, Keinänen-Kiukaanniemi J, Heikkinen S, et al. Effect of exercise on extraskeletal risk factors for hip fractures in elderly women with low BMD: a population-based randomized controlled trial. J Bone Miner Res. 2006;21(5):772–9.CrossRef Korpelainen R, Keinänen-Kiukaanniemi J, Heikkinen S, et al. Effect of exercise on extraskeletal risk factors for hip fractures in elderly women with low BMD: a population-based randomized controlled trial. J Bone Miner Res. 2006;21(5):772–9.CrossRef
36.
Zurück zum Zitat Korpelainen R, Keinänen-Kiukaanniemi J, Heikkinen S, et al. Effect of impact exercise on bone mineral density in elderly women with low BMD: a population-based randomized controlled 30-month intervention. Osteoporos Int. 2006;17(1):109–18.CrossRef Korpelainen R, Keinänen-Kiukaanniemi J, Heikkinen S, et al. Effect of impact exercise on bone mineral density in elderly women with low BMD: a population-based randomized controlled 30-month intervention. Osteoporos Int. 2006;17(1):109–18.CrossRef
37.
Zurück zum Zitat Liu-Ambrose T, Khan K, Eng J, et al. Resistance and agility training reduce fall risk in women aged 75 to 85 with low bone mass: a 6-month randomized, controlled trial. J Am Geriatr Soc. 2004;52(5):657–65.CrossRef Liu-Ambrose T, Khan K, Eng J, et al. Resistance and agility training reduce fall risk in women aged 75 to 85 with low bone mass: a 6-month randomized, controlled trial. J Am Geriatr Soc. 2004;52(5):657–65.CrossRef
38.
Zurück zum Zitat Liu-Ambrose T, Khan K, Eng J, et al. Both resistance and agility training increase cortical bone density in 75- to 85-year-old women with low bone mass: a 6-month randomized controlled trial. J Clin Densitom. 2004;7(4):390–8.CrossRef Liu-Ambrose T, Khan K, Eng J, et al. Both resistance and agility training increase cortical bone density in 75- to 85-year-old women with low bone mass: a 6-month randomized controlled trial. J Clin Densitom. 2004;7(4):390–8.CrossRef
39.
Zurück zum Zitat Liu-Ambrose T, Khan K, Eng J, et al. Balance confidence improves with resistance or agility training. Increase is not correlated with objective changes in fall risk and physical abilities. Gerontology. 2004;50(6):373–82.CrossRef Liu-Ambrose T, Khan K, Eng J, et al. Balance confidence improves with resistance or agility training. Increase is not correlated with objective changes in fall risk and physical abilities. Gerontology. 2004;50(6):373–82.CrossRef
40.
Zurück zum Zitat Liu-Ambrose T, Khan K, Eng J, et al. Both resistance and agility training reduce back pain and improve health-related quality of life in older women with low bone mass. Osteoporos Int. 2005;16(11):1321–9.CrossRef Liu-Ambrose T, Khan K, Eng J, et al. Both resistance and agility training reduce back pain and improve health-related quality of life in older women with low bone mass. Osteoporos Int. 2005;16(11):1321–9.CrossRef
41.
Zurück zum Zitat Marchese DI, D’Andrea M, Ventura V, et al. Effects of a weight-bearing exercise training on bone mineral density and neuromuscular function of osteopenic women. Eur J Inflamm. 2012;10(3):427–35.CrossRef Marchese DI, D’Andrea M, Ventura V, et al. Effects of a weight-bearing exercise training on bone mineral density and neuromuscular function of osteopenic women. Eur J Inflamm. 2012;10(3):427–35.CrossRef
42.
Zurück zum Zitat Olsen C, Bergland A. The effect of exercise and education on fear of falling in elderly women with osteoporosis and a history of vertebral fracture: results of a randomized controlled trial. Osteoporos Int. 2014;25(8):2017–25.CrossRef Olsen C, Bergland A. The effect of exercise and education on fear of falling in elderly women with osteoporosis and a history of vertebral fracture: results of a randomized controlled trial. Osteoporos Int. 2014;25(8):2017–25.CrossRef
43.
Zurück zum Zitat Papaioannou A, Adachi JD, Winegard K, et al. Efficacy of home-based exercise for improving quality of life among elderly women with symptomatic osteoporosis-related vertebral fractures. Osteoporos Int. 2003;14(8):677–82.CrossRef Papaioannou A, Adachi JD, Winegard K, et al. Efficacy of home-based exercise for improving quality of life among elderly women with symptomatic osteoporosis-related vertebral fractures. Osteoporos Int. 2003;14(8):677–82.CrossRef
50.
Zurück zum Zitat Wen H, Huang Y, Li T, et al. Effects of short-term step aerobics exercise on bone metabolism and functional fitness in postmenopausal women with low bone mass. Osteoporos Int. 2017;28(2):539–47.CrossRef Wen H, Huang Y, Li T, et al. Effects of short-term step aerobics exercise on bone metabolism and functional fitness in postmenopausal women with low bone mass. Osteoporos Int. 2017;28(2):539–47.CrossRef
51.
Zurück zum Zitat Howe T, Shea B, Dawson L, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev. 2011;7. Howe T, Shea B, Dawson L, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev. 2011;7.
52.
Zurück zum Zitat Kelley G, Kelley K, Kohrt W. Effects of ground and joint reaction force exercise on lumbar spine and femoral neck bone mineral density in postmenopausal women: a meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2012;20(13):177.CrossRef Kelley G, Kelley K, Kohrt W. Effects of ground and joint reaction force exercise on lumbar spine and femoral neck bone mineral density in postmenopausal women: a meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2012;20(13):177.CrossRef
53.
Zurück zum Zitat Zehnacker CH, Bemis-Dougherty A. Effect of weighted exercises on bone mineral density in post menopausal women a systematic review. J Geriatr Phys Ther. 2007;30(2):79–88.CrossRef Zehnacker CH, Bemis-Dougherty A. Effect of weighted exercises on bone mineral density in post menopausal women a systematic review. J Geriatr Phys Ther. 2007;30(2):79–88.CrossRef
54.
Zurück zum Zitat Kemmler W, Von Stengel S. High-intensity exercise to prevent fractures—risk or gain? Nat Rev Endocrinol. 2018;14(1):6–8.CrossRef Kemmler W, Von Stengel S. High-intensity exercise to prevent fractures—risk or gain? Nat Rev Endocrinol. 2018;14(1):6–8.CrossRef
55.
Zurück zum Zitat Kemmler W, Bebenek M, Kohl M, et al. Exercise and fractures in postmenopausal women. Final results of the controlled Erlangen Fitness and Osteoporosis Prevention Study (EFOPS). Osteoporos Int. 2015;26(10):2491–9.CrossRef Kemmler W, Bebenek M, Kohl M, et al. Exercise and fractures in postmenopausal women. Final results of the controlled Erlangen Fitness and Osteoporosis Prevention Study (EFOPS). Osteoporos Int. 2015;26(10):2491–9.CrossRef
56.
Zurück zum Zitat Vainionpää A, Korpelainen R, Vihriälä E, et al. Intensity of exercise is associated with bone density change in premenopausal women. Osteoporos Int. 2006;17(3):455–63.CrossRef Vainionpää A, Korpelainen R, Vihriälä E, et al. Intensity of exercise is associated with bone density change in premenopausal women. Osteoporos Int. 2006;17(3):455–63.CrossRef
57.
Zurück zum Zitat Sherrington C, Fairhall N, Wallbank G, et al. Exercise for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2019;1. Sherrington C, Fairhall N, Wallbank G, et al. Exercise for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2019;1.
58.
Zurück zum Zitat Gibbs J, MacIntyre N, Ponzano M, et al. Exercise for improving outcomes after osteoporotic vertebral fracture. Cochrane Database Syst Rev. 2019;7. Gibbs J, MacIntyre N, Ponzano M, et al. Exercise for improving outcomes after osteoporotic vertebral fracture. Cochrane Database Syst Rev. 2019;7.
59.
Zurück zum Zitat Brown J, Josee R. The Scientific Advisory Council of the Osteoporosis Society of Canada. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ. 2002;167(10):S1–34.PubMedPubMedCentral Brown J, Josee R. The Scientific Advisory Council of the Osteoporosis Society of Canada. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ. 2002;167(10):S1–34.PubMedPubMedCentral
60.
Zurück zum Zitat Cauley JA, Thompson DE, Ensrud KC, et al. Risk of mortality following clinical fractures. Osteoporos Int. 2000;11:556–61.CrossRef Cauley JA, Thompson DE, Ensrud KC, et al. Risk of mortality following clinical fractures. Osteoporos Int. 2000;11:556–61.CrossRef
62.
Zurück zum Zitat Stel V, Smit J, Pluijm M, et al. Consequences of falling in older men and women and risk factors for health service use and functional decline. Age Ageing. 2004;33(1):58–65.CrossRef Stel V, Smit J, Pluijm M, et al. Consequences of falling in older men and women and risk factors for health service use and functional decline. Age Ageing. 2004;33(1):58–65.CrossRef
Metadaten
Titel
The Effect of Impact Exercise (Alone or Multicomponent Intervention) on Health-Related Outcomes in Individuals at Risk of Fractures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
verfasst von
Isabel B. Rodrigues
Matteo Ponzano
Zeinab Hosseini
Lehana Thabane
Philip D. Chilibeck
Debra A. Butt
Maureen C. Ashe
Jackie Stapleton
John Wark
Lora M. Giangregorio
Publikationsdatum
29.04.2021
Verlag
Springer International Publishing
Erschienen in
Sports Medicine / Ausgabe 6/2021
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-021-01432-x

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