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Current Behavioral Neuroscience Reports
Erschienen in: Current Behavioral Neuroscience Reports 2/2014

01.06.2014 | Neuromodulation (D Dougherty, Section Editor)

Vagus Nerve Stimulation

verfasst von: Robert H. Howland

Erschienen in: Current Behavioral Neuroscience Reports | Ausgabe 2/2014

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Abstract

The vagus nerve is a major component of the autonomic nervous system, has an important role in the regulation of metabolic homeostasis, and plays a key role in the neuro-endocrine-immune axis to maintain homeostasis through its afferent and efferent pathways. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, including manual or electrical stimulation. Left cervical VNS is an approved therapy for refractory epilepsy and for treatment-resistant depression. Right cervical VNS is effective for treating heart failure in preclinical studies and a phase II clinical trial. The effectiveness of various forms of non-invasive transcutaneous VNS for epilepsy, depression, primary headaches, and other conditions has not been investigated beyond small pilot studies. The relationship between depression, inflammation, metabolic syndrome, and heart disease might be mediated by the vagus nerve. VNS deserves further study for its potentially favorable effects on cardiovascular, cerebrovascular, metabolic, and other physiologic biomarkers associated with depression morbidity and mortality.
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Metadaten
Titel
Vagus Nerve Stimulation
verfasst von
Robert H. Howland
Publikationsdatum
01.06.2014
Verlag
Springer International Publishing
Erschienen in
Current Behavioral Neuroscience Reports / Ausgabe 2/2014
Elektronische ISSN: 2196-2979
DOI
https://doi.org/10.1007/s40473-014-0010-5

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