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The Report-AGE project: a permanent epidemiological observatory to identify clinical and biological markers of health outcomes in elderly hospitalized patients in Italy

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Abstract

Background

Italy is expected to experience the largest growth in persons ≥65 years (>20 % by 2020). This demographic shift allows for geriatric research on predictive clinical and biological markers of outcomes related to frailty, re-hospitalization and mortality.

Aims

To describe rationale and methods of the Report-AGE study project of acute care patients in Italian National Research Center on Aging (INRCA) research hospitals.

Methods

Report-AGE study is a large observational study on health conditions and outcomes of hospitalized elderly patients (≥65 years). The primary objective of the study is to create a high-level data resource of demographics, comprehensive geriatric assessments, clinical and diagnostic information, as well as biological and molecular markers in all older patients admitted to INRCA Hospitals. Assessments in physical and nutritional parameters, co-morbid health conditions, and associations with frailty parameters are ongoing in older hospitalized adults following an acute event. Study collection began in September 2011.

Results

Up to date, there are 3479 patients ≥65 years (mean age: 85 ± 7years) with 1543 men and 1936 women enrolled. Data have been recorded regarding functional and clinical parameters before, during hospital admission and at discharge. Data collection for primary outcome analyses related to re-hospitalization and mortality is estimated for September 2016.

Discussion

This study aims at collecting precise clinical data, comprehensive geriatric assessment, risk factors, and biological data from acute care patients. Data will also be used to identify mechanisms underlying frailty in this specific population.

Conclusion

This study provides a descriptive epidemiological collection of the health conditions of older in-patients.

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Acknowledgments

This study is exclusively funded by INRCA. The trial registration number is: NCT01397682.

Conflict of interest

All authors declare no conflicts of interest.

Human and Animal Rights

The Ethical Committee of the Italian National Research Center on Aging has approved the study protocol which was in accordance with 1964 Helsinksi declaration. This protocol does not contain any studies with animals performed by any of the authors.

Informed consent

Signed informed consent was obtained from all participants in the study.

Author information

Authors and Affiliations

  1. Scientific Direction, Italian National Research Center on Aging (INRCA), Via Santa Margherita, Ancona, Italy

    Silvia Bustacchini, Angela Marie Abbatecola, Anna Rita Bonfigli, Carlos Chiatti, Giuseppina Di Stefano, Rosamaria Lisa & Fabrizia Lattanzio

  2. Unit of Geriatric Pharmacoepidemiology, Research Hospital of Cosenza, Italian National Research Center on Aging (INRCA), Cosenza, Italy

    Andrea Corsonello

  3. Clinical and Molecular Diagnostic Laboratory, Italian National Research Center on Aging (INRCA), Ancona, Italy

    Roberta Galeazzi

  4. Biostatistical Centre, Italian National Research Center on Aging (INRCA), Ancona, Italy

    Paolo Fabbietti

  5. Unit of Pulmonary Rehabilitation, Research Hospital of Casatenovo, Italian National Research Centre on Aging (INRCA), Casatenovo, Italy

    Enrico E. Guffanti

  6. Scientific Technological Area, Advanced Technology Center for Aging Research, Italian National Research Center on Aging (INRCA), Ancona, Italy

    Mauro Provinciali

Authors
  1. Silvia Bustacchini
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  2. Angela Marie Abbatecola
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  4. Carlos Chiatti
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  5. Andrea Corsonello
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  6. Giuseppina Di Stefano
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  8. Paolo Fabbietti
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  9. Rosamaria Lisa
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  10. Enrico E. Guffanti
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  11. Mauro Provinciali
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  12. Fabrizia Lattanzio
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Corresponding author

Correspondence to Angela Marie Abbatecola.

Additional information

On behalf of Report-Age study group. The members of this group are listed in “Appendix”.

Appendix

Appendix

This paper was prepared on behalf of the Report-Age Study Group at IRCCS INRCA Research Hospitals of Ancona, Fermo, Casatenovo and Cosenza (Italy). Scientific Coordinator: F. Lattanzio. Coordinating Working Group: S. Bustacchini, A. Corsonello, R. Antonicelli, A. Cherubini, E. E. Guffanti, D. Postacchini, L. Spazzafumo, P. Fabbietti, M. Di Rosa, M. Provinciali, F. Busco, R. Galeazzi, A. R. Bonfigli, G. Di Stefano, R. Lisa, C. Maffei, S. David, L. Ferrara, C. Chiatti. Technical Support: R. Arzeni, L. Rossi, R. Firmani, M. Nacciariti, F. Marchegiani, R. Rossini, M. G. Palermi. Clinical Centers: P. Gasparrini, A. Scrimieri, G. Dell’Aquila, P. L. Dessì Fulgheri, E. Espinosa, O. Scarpino, S. Castellani, M. Dellabella, L. Gasparri, C. Giuli, M. Migale, A. Bianchi, C. Misuraca, B. Mazzei, S. Garasto.

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Bustacchini, S., Abbatecola, A.M., Bonfigli, A.R. et al. The Report-AGE project: a permanent epidemiological observatory to identify clinical and biological markers of health outcomes in elderly hospitalized patients in Italy. Aging Clin Exp Res 27, 893–901 (2015). https://doi.org/10.1007/s40520-015-0350-3

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