nach oben

Journal of Endocrinological Investigation

Erschienen in:

01.03.2014 | Review

Management of craniopharyngiomas

verfasst von: N. Karavitaki

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 3/2014

Einloggen, um Zugang zu erhalten

Abstract

Craniopharyngiomas are rare epithelial tumours arising along the path of the craniopharyngeal duct. Their pathogenesis remains uncertain and they can present with a variety of manifestations attributed to pressure effects to surrounding structures. The optimal management of craniopharyngiomas remains challenging mainly due to their sharp, irregular borders and their tendency to adhere to vital neurovascular structures making surgical manipulations potentially hazardous to vital brain areas. Non-aggressive surgery followed by radiotherapy is currently the most widely used option possibly achieving the most optimal long-term outcome. Other treatment modalities including intracystic irradiation, intracystic instillation of antineoplasmatic agents and stereotactic radiotherapy are also available in our armamentarium. The long-term morbidities related with the craniopharyngiomas and their treatment remain significant, with hypothalamic damage playing the protagonist role and requiring further studies to identify measures that will improve the prognosis of the patients.

Karavitaki N, Cudlip S, Adams CB, Wass JA (2006) Craniopharyngiomas. Endocr Rev 2006(27):371–397CrossRef

Larkin SJ, Ansorge O (2013) Pathology and pathogenesis of craniopharyngiomas. Pituitary 16(1):9–17PubMed

Crotty TB, Scheithauer BW, Young WF Jr et al (1997) Papillary craniopharyngioma: a clinicopathological study of 48 cases. J Neurosurg 83:206–214CrossRef

Petito CK, De Girolami U, Earle KM (1976) Craniopharyngiomas: a clinical and pathological review. Cancer 37:1944–1952CrossRefPubMed

Weiner HL, Wisoff JH, Rosenberg ME et al (1994) Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery 35:1001–1011CrossRefPubMed

Fahlbusch R, Honegger J, Paulus W, Huk W, Buchfelder M (1999) Surgical treatment of craniopharyngiomas: experience with 168 patients. J Neurosurg 90:237–250CrossRefPubMed

Karavitaki N, Brufani C, Warner JT et al (2005) Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol 62:397–409CrossRef

Van Effentere R, Boch AL (2002) Craniopharyngioma in adults and children: a study of 122 surgical cases. J Neurosurg 97(1):3–11

Sartoretti-Schefer S, Wichmann W, Aguzzi A, Valavanis A (1997) MRI differentiation of adamantinous and squamous-papillary craniopharyngiomas. Am J Neuroradiol 18(1):77–87PubMed

10.

Byrne JV (2002) Imaging of the pituitary. In: Wass JAH, Shalet SM (eds) Oxford textbook of endocrinology and diabetes, 1st edn. Oxford University Press, Oxford, pp 136–145

11.

Komotar RJ, Starke RM (2012) Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas. World Neurosurg 77(2):329–341CrossRefPubMed

12.

Buchfelder M, Schlaffer SM, Lin F, Kleindienst A (2013) Surgery for craniopharyngioma. Pituitary 16:18–25CrossRefPubMed

13.

Elliott RE, Jane JA Jr, Wisoff JH (2011) Surgical management of craniopharyngiomas in children: meta-analysis and comparison of transcranial and transsphenoidal approaches. Neurosurgery 69(3):630–643CrossRefPubMed

14.

Carpenter RC, Chamberlin GW, Frazier CH (1937) The treatment of hypophyseal stalk tumours by evacuation and irradiation. Am J Roent 38:162–167

15.

Kramer S, Mckissock W, Concanon JP (1961) Craniopharyngiomas: treatment by combined surgery and radiation therapy. J Neurosurg 18:217–226CrossRefPubMed

16.

Costine LS, Randall SH, Rubin P, McDonald J (1989) Craniopharyngiomas: fluctuation in cyst size following surgery and radiation therapy. Neurosurgery 24:53–59CrossRef

17.

Rajan B, Ashley S, Thomas DGT et al (1997) Craniopharyngioma: improving outcome by early recognition and treatment of acute complications. Int J Radiat Oncol Biol Phys 37:517–521CrossRefPubMed

18.

Shi Z, Esiashvili N, Janss AJ et al (2012) Transient enlargement of craniopharyngioma after radiation therapy: pattern of magnetic resonance imaging response following radiation. J Neurooncol 109(2):349–355CrossRefPubMed

19.

Minniti G, Saran F, Traish D et al (2007) Fractionated stereotactic conformal radiotherapy following conservative surgery in the control of craniopharyngiomas. Radiother Oncol 82:90–95CrossRefPubMed

20.

Combs SE, Thilmann C, Huber PE et al (2007) Achievement of long term control in patients with craniopharyngiomas using high precision stereotactic radiotherapy. Cancer 109:2308–2314CrossRefPubMed

21.

Rajan B, Ashley S, Gorman C et al (1993) Craniopharyngioma—long-term results following limited surgery and radiotherapy. Radiother Oncol 26:1–10CrossRefPubMed

22.

Jose CC, Rajan B, Ashley S, Marsh H, Brada M (1992) Radiotherapy for the treatment of recurrent craniopharyngioma. Clin Oncol 4:287–289CrossRef

23.

Gutin DH, Klemme WM, Lagger RI, Mackay AR, Pitts LH, Hojobuchi Y (1980) Management of unresectable cystic craniopharyngioma by aspiration through an Ommaya reservoir drainage system. J Neurosurg 52:36–40CrossRefPubMed

24.

Spaziante R, Irace C, De Divitiis E (1993) Brachytherapy of cystic craniopharyngiomas. J Neurosurg 79:966–967PubMed

25.

Pollock BE, Lunsford LD, Kondziolka D, Levine G, Flickinger JC (1995) Phosphorus-32 intracavitary irradiation of cystic craniopharyngiomas: current technique and long-term results. Int J Radiat Oncol Biol Phys 33:437–446CrossRefPubMed

26.

Voges J, Sturm V, Lehrke R, Treuer H, Gauss C, Berthold F (1997) Cystic craniopharyngioma: long-term results after intracavitary irradiation with stereotactically applied colloidal b-emitting radioactive sources. Neurosurgery 40:263–270CrossRefPubMed

27.

Van den Berge JH, Blaauw G, Breeman WAP, Rahmy A, Wijngaarde R (1992) Intracavitary brachytherapy of cystic craniopharyngiomas. J Neurosurg 77:545–550CrossRefPubMed

28.

Hasegawa T, Kondzilka D, Hadjipanayis CG, Lunsford LD (2004) Management of cystic craniopharyngiomas with phosphorus-32 intracavitary irradiation. Neurosurgery 54:813–822CrossRefPubMed

29.

Julow JV (2013) Intracystic irradiation for craniopharyngiomas. Pituitary 16(1):34–35PubMed

30.

Kickingereder P, Maarouf M, El Majdoub F et al (2012) Intracavitary brachytherapy using stereotactically applied phosphorus-32 colloid for treatment of cystic craniopharyngiomas in 53 patients. J Neurooncol 109(2):365–367CrossRefPubMed

31.

Takahashi H, Nakazawa S, Shimura T (1985) Evaluation of postoperative injection of bleomycin for craniopharyngioma in children. J Neurosurg 62:120–127CrossRefPubMed

32.

Hader WJ, Steinbok P, Hukin J, Fryer C (2000) Intratumoral therapy with bleomycin for cystic craniopharyngiomas in children. Pediatr Neurosurg 33:211–218CrossRefPubMed

33.

Broggi G, Franzini A, Cajola L, Pluchino F (1994) Cell kinetic investigations in craniopharyngioma: preliminary results and considerations. Pediatr Neurosurg 21:21–23CrossRefPubMed

34.

Leber KA, Bergloeff J, Pendl G (1998) Dose response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery. J Neurosurg 88:43–50CrossRefPubMed

35.

Xu Z, Yen CP, Schlesinger D et al (2011) Outcomes of gamma knife surgery for craniopharyngioma. J Neurooncol 104(1):305–313CrossRefPubMed

36.

Niranjan A, Kano H, Mathieu D et al (2010) Radiosurgery for craniopharyngioma. Int J Radiat Oncol Biol Phys 78(1):64–71CrossRefPubMed

37.

Kobayashi T, Kida Y, Mori Y et al (2005) Long-term results of gamma knife surgery for treatment of craniopharyngioma in 98 consecutive cases. J Neurosurg Pediatr 103(suppl):482–488CrossRef

38.

Aggarwal A, Fersht N, Brada M (2013) Radiotherapy for craniopharyngioma. Pituitary 16(1):26–33PubMed

39.

Bremmer AM, Nguyen TQ, Balsys R (1984) Therapeutic benefits of combination chemotherapy with vincristine, BCNU, and procarbazine on recurrent cystic craniopharyngioma. A case report. J Neurooncol 2:47–51CrossRef

40.

Lippens RJ, Rotteveel JJ, Otten BJ, Merx H (1998) Chemotherapy with adriamycin (doxorubicin) and CCNU (lomustine) in four children with recurrent craniopharyngioma. Eur J Paediatr Neurol 2:263–268CrossRefPubMed

41.

Yeung JT, Pollack IF, Panigraphy et al (2012) Pegylated interferon-a-2b for children with recurrent craniopharyngioma. J Neurosurg Pediatr 10(6):498–503CrossRefPubMed

42.

Jakacki RI, Cohen BH, Jamison C et al (2000) Phase II evaluation of interferon-α-2a for progressive recurrent craniopharyngiomas. J Neurosurg 92:250–260CrossRef

43.

Cohen M, Bartels U, Branson H, Kulkarni AV, Hamilton J (2013) Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011. Neuro Oncol 15(6):767–774CrossRefPubMed

44.

Toledano Y, Lubetsky A, Shimon I (2007) Acquired prolactin deficiency in patients with disorders of the hypothalamic-pituitary axis. J Endocrinol Invest 30:268–273PubMed

45.

De Vile CJ, Grant DB, Hayward RD, Stanhope R (1996) Growth and endocrine sequelae of craniopharyngioma. Arch Dis Child 75:108–114CrossRef

46.

Schoenle EJ, Zapf J, Prader A, Torresani T, Werder EA, Zachemann M (1995) Replacement of growth hormone (GH) in normally growing GH-deficient patients operated for craniopharyngioma. J Clin Endocrinol Metab 80:374–378PubMed

47.

Sklar CA (1994) Craniopharyngioma: endocrine sequelae of treatment. Pediatr Neurosurg 21:120–123CrossRefPubMed

48.

Kendall-Taylor P, Jönsson PJ, Abs R et al (2005) The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma. Eur J Endocrinol 152:557–567CrossRefPubMed

49.

Price DA, Wilton P, Jonsson P et al (1998) Efficacy and safety of growth hormone treatment in children with prior craniopharyngioma: an analysis of Pharmacia and Upjohn International Growth Database (KIGS) from 1988 to 1996. Horm Res 49:91–97CrossRef

50.

Geffner M, Lundberg M, Koltowska-Haggstrom M et al (2004) Changes in height, weight, and body mass index in children with craniopharyngioma after three years of growth hormone therapy: analysis of KIGS (Pfizer International Growth Database). J Clin Endocrinol Metab 89:5435–5440CrossRefPubMed

51.

Verhelst J, Kendall-Taylor P, Erfurth EM et al (2005) Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database). J Clin Endocrinol Metab 90:4636–4643CrossRefPubMed

52.

Ulfarsson E, Karstrom A, Yin S et al (2005) Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. Clin Cancer Res 11:4674–4680CrossRefPubMed

53.

Karavitaki N (2007) Hypopituitarism oddities: craniopharyngiomas. Horm Res 68(Suppl 5):151–153CrossRefPubMed

54.

Karavitaki N, Warner JT, Marland A et al (2006) GH replacement does not increase the risk of recurrence in patients with craniopharyngiomas. Clin Endocrinol 64:556–560CrossRef

55.

Daousi C, Dunn AJ, Foy PM, MacFarlane IA, Pinkney JH (2005) Endocrine and neuroanatomic features associated with weight gain and obesity in adult patients with hypothalamic damage. JAMA 118:45–50CrossRef

56.

Stripp DC, Maity A, Janss AJ et al (2004) Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults. Int J Radiat Oncol Biol Phys 28:714–720CrossRef

57.

Pereira AM, Scmid EM, Schutte PJ et al (2005) High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngiomas. Clin Endocrinol 62:197–204CrossRef

58.

De Vile CJ, Grant DB, Hayward RD, Kendall BE, Neville BGR, Stanhope R (1996) Obesity in childhood craniopharyngioma: relation to post-operative hypothalamic damage shown by magnetic resonance imaging. J Clin Endocrinol Metab 81:2734–2737PubMed

59.

Roth C, Wilken B, Hanefeld F, Schroter F, Leonhardt U (1998) Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite. Eur J Endocrinol 138:89–91CrossRefPubMed

60.

Pinkney J, Wilding J, Williams G, MacFarlane I (2002) Hypothalamic obesity in humans: what do we know and what can be done? Obes Rev 3:27–34CrossRefPubMed

61.

Harz KJ, Muller HL, Waldeck E, Pudel V, Roth C (2003) Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity. J Clin Endocrinol Metab 88:5227–5231CrossRefPubMed

62.

Holmer H, Pozarek G, Wirfält E et al (2010) Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma. J Clin Endocrinol Metab 95:5395–5402CrossRefPubMed

63.

Piguel P, Abraham P, Bouchours-Nouet N et al (2012) Impaired aerobic exercise adaptation in children and adolescents with craniopharyngioma is associated with hypothalamic involvement. Eur J Endocrinol 166:215–222CrossRefPubMed

64.

Goldstone AP, Patterson M, Kalingag N et al (2005) Fasting and post-prandial hyperghrelinemia in Prader–Willi syndrome is partially explained by hypoinsulinemia, and is not due to PYY deficiency or seen in hypothalamic obesity due to craniopharyngioma. J Clin Endocrinol Metab 90:2681–2690CrossRefPubMed

65.

Elowe-Gruau E, Beltrand J, Brauner R et al (2013) Childhood craniopharyngioma; hypothalamus-sparing surgery decreases the risk of obesity. J Clin Endocrinol Metab 98(6):2376–2382CrossRefPubMed

66.

Bretault M, Boillot A, Muzzard L et al (2013) Clinical review: bariatric surgery following treatment for craniopharyngioma: a systematic review and individual-level data meta-analysis. J Clin Endocrinol Metab 98(6):2239–2246CrossRefPubMed

67.

Weismann D, Pelka T, Bender G et al (2013) Bariatric surgery for morbid obesity in craniopharyngioma. Clin Endocrinol 78:385–390CrossRef

68.

Mason PW, Krawiecki N, Meacham LR (2002) The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatr Adolesc Med 156:887–892CrossRefPubMed

69.

Hamilton JK, Conwell LS, Syme C, Ahmet A, Jeffery A, Daneman D (2011) Hypothalamic obesity following craniopharyngioma surgery: results of a pilot trial of combined diazoxide and metformin therapy. Int J Pediatr Endocrinol 2011:417949CrossRefPubMedCentralPubMed

70.

Lustig RH, Hinds PS, Ringwald-Smith K et al (2003) Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab 88:2586–2592CrossRefPubMed

71.

Zoicas F, Droste M, Mayr B, Buchfelder M, Schofl C (2013) GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases. Eur J Endocrinol 168(5):699–706CrossRefPubMed

72.

Duff JM, Meyer FB, Ilstrup DM, Laws ERJr, Scleck CD, Scheithauer BW (2000) Long-term outcomes for surgically resected craniopharyngiomas. Neurosurgery 46(2):291–305CrossRefPubMed

73.

Gautier A, Godbout A, Grosheny C et al (2012) Markers of recurrence and long-term morbidity in craniopharyngioma: a systematic analysis of 171 patients. J Clin Endocrinol Metab 97(4):1258–1267CrossRefPubMed

74.

Di Pinto M, Conklin HM, Merchant TE (2012) Learning and memory following conformal radiation therapy for paediatric craniopharyngioma and low-grade glioma. Int J Radiat Oncol Biol Phys 84(3):363–369CrossRef

75.

Varlotto JM, Flickinger JC, Kondziolka D, Lunsford LD, Deutch M (2002) External beam irradiation of craniopharyngiomas: long-term analysis of tumour control and morbidity. Int J Radiat Oncol Biol Phys 54:492–499CrossRefPubMed

76.

Erfurth EM, Holmer H, Fjalldal SB (2013) Mortality and morbidity in adult craniopharyngioma. Pituitary 16(1):46–55CrossRefPubMed

Titel: Management of craniopharyngiomas
verfasst von: N. Karavitaki
Publikationsdatum: 01.03.2014
Verlag: Springer International Publishing
Erschienen in: Journal of Endocrinological Investigation / Ausgabe 3/2014
Elektronische ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-013-0050-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Management of craniopharyngiomas

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2014

Sarcopenia and sarcopenic obesity and their association with dyslipidemia in Korean elderly men: the 2008–2010 Korea National Health and Nutrition Examination Survey

Severe fatigue in patients with adrenal insufficiency: physical, psychosocial and endocrine determinants

Management of adrenal cancer: a 2013 update

Male gender differences in the thyroid ultrasound features, thyroid peroxidase antibodies and thyroid hormone levels: a large population-based study

The influence of high glucose and high insulin on mechanisms controlling cell cycle progression and arrest in mouse C2C12 myoblasts: the comparison with IGF-I effect

Subclinical hyperthyroidism when presenting as initial manifestation of juvenile Hashimoto’s thyroiditis: first report on its natural history

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin