Skip to main content

Advertisement

SpringerLink
Log in

Toward a physiological referent for the vitamin D requirement

  • Opinion
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. IOM (Institute of Medicine) (2011) Dietary reference intakes for calcium and vitamin D. The National Academies Press, Washington DC

  2. Liu PT, Stenger S, Li H et al (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311(5768):1770–1773

    Article  PubMed  CAS  Google Scholar 

  3. Franceschi RT, Li Y (2011) Vitamin D regulation of osteoblast function. In: Feldman D, Pike W, Adams J (eds) Chapter 17 in “vitamin D”, 3rd edn. Academic Press, San Diego

    Google Scholar 

  4. Lieben L, Masuyama R, Torrekens S et al (2014) Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest 122:1803–1815

    Article  Google Scholar 

  5. Heaney RP (2012) The nutrient problem. Nutr Rev 70:165–169

    Article  PubMed  Google Scholar 

  6. Szent-Gyorgi A, Hyman M (2004) Paradigm shift: the end of “normal science” in medicine. Altern Ther 10(10–15):90–94

    Google Scholar 

  7. Sahota O, Mundey MK, Godber IM, Hosking DJ (2006) Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Osteoporos Int 17:1013–1021

    Article  PubMed  CAS  Google Scholar 

  8. Chapuy M-C, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7:439–443

    Article  PubMed  CAS  Google Scholar 

  9. Aloia JF, Talwar SA, Pollack S, Feuerman M, Yeh JK (2006) Optimal vitamin D status and serum parathyroid hormone concentrations in African American women. Am J Clin Nutr 84:602–609

    PubMed  CAS  PubMed Central  Google Scholar 

  10. Ginde AA, Wolfe P, Camargo CA, Schwartz RS (2012) Defining vitamin D status by secondary hyperparathyroidism in the US population. J Endocrinol Invest 35:42–48

    PubMed  CAS  Google Scholar 

  11. Hollis BW, Wagner CL (2013) The role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes. J Clin Endocrinol Metab 98:4619–4628

    Article  PubMed  CAS  Google Scholar 

  12. Heaney RP, Armas, LAG. Quantifying the vitamin D economy. Nutr Rev (in press) 2014

  13. Heaney RP, Armas LAG, Shary JR, Bell NH, Binkley N, Hollis BW (2008) 25-hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr 87:1730–1737

    Google Scholar 

  14. Luxwolda MF, Kuipers RS, Kema IP, Dijck-Brouwer DAJ, Muskiet FAJ (2012) Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/L. Br J Nutr 108:1557–1561

    Article  PubMed  CAS  Google Scholar 

  15. Hathcock JN, Shao A, Vieth R, Heaney RP (2007) Risk assessment for vitamin D. Am J Clin Nutr 85:6–18

    PubMed  CAS  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Creighton University, 2500 California Plaza, Omaha, NE, 68132, USA

    R. P. Heaney

Authors
  1. R. P. Heaney
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. P. Heaney.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heaney, R.P. Toward a physiological referent for the vitamin D requirement. J Endocrinol Invest 37, 1127–1130 (2014). https://doi.org/10.1007/s40618-014-0190-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40618-014-0190-6

Keywords

Search

Navigation