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Erschienen in: Journal of Endocrinological Investigation 5/2022

01.05.2022 | Rapid Communication

Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion

verfasst von: B. Pla Peris, A. Á. Merchante Alfaro, F. J. Maravall Royo, P. Abellán Galiana, S. Pérez Naranjo, M. González Boillos

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 5/2022

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Abstract

Aim

To describe a case series of thyrotoxicosis likely triggered by SARS-CoV-2 vaccination and to warn physicians about this potential correlation. To report clinical, laboratory and imaging findings and provide further information that goes in line with the underlying mechanisms.

Methods

Single-center case series based on all the information collected in the hospital medical records, as well as the temporal sequence between the onset of symptoms and COVID-19 vaccination.

Results

We report 8 cases with thyrotoxicosis after SARS-CoV-2 vaccination. 4 cases of Graves’ disease (GD), 2 cases of subacute painful thyroiditis (SAT), 1 case of concurrent GD and SAT and 1 case of atypical subacute thyroiditis. Five patients received BNT162b2 mRNA vaccine, 3 patients 1273 mRNA vaccine. The onset of symptoms following vaccination ranged from 10 to 14 days in six of eight patients and from 7 to 8 weeks in two patients.

Conclusions

Several hypotheses have been proposed to explain the potential correlation between SARS-CoV-2 vaccination and thyrotoxicosis, including immune system hyper-stimulation, molecular mimicry and Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA). We should pay greater attention to thyroid disorders in patients receiving vaccine against SARS-CoV-2.
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Metadaten
Titel
Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion
verfasst von
B. Pla Peris
A. Á. Merchante Alfaro
F. J. Maravall Royo
P. Abellán Galiana
S. Pérez Naranjo
M. González Boillos
Publikationsdatum
01.05.2022
Verlag
Springer International Publishing
Erschienen in
Journal of Endocrinological Investigation / Ausgabe 5/2022
Elektronische ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-022-01739-0

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