Abstract
The pork-cat syndrome is an IgE-mediated allergy to pork triggered by a primary sensitization to cat dander. IgE-antibodies are directed to cat serum albumin, Fel d 2, and cross-react with porcine serum albumin. In contrast to meat anaphylaxis caused by IgE to α-Gal, in patients with pork-cat syndrome, symptoms occur in less than two hours after consumption. As albumin is a thermolabile allergen, patients often tolerate well done meat. In this review, different allergens of red meat are described and an original case of allergy to horse meat mediated by allergy to dog dander is presented.
Similar content being viewed by others
Abbreviations
- ELISA:
-
Enzyme-linked immunosorbent assay
- Ig:
-
Immunoglobulin
- RAST:
-
Radioallergosorbent test
- SA:
-
Serum albumin
- SDS-PAGE:
-
Sodium dodecylsulfate polyacrylamide gel electrophoresis
References
Dreborg S. Skin test in diagnosis of food allergy. Allergy Proc 1991;12:251–4.
Steinke M, Fiocchi A, Kirchlechner V, Steinke M, Fiocchi A, Kirchlechner V, et al; REDALL study consortium. Perceived food allergy in children in 10 European nations. A randomised telephone survey. Int Arch Allergy Immunol 2007;143:290–5.
Schafer T, Bohler E, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, et al. Epidemiology of food allergy/food intolerance in adults: associations with other manifestations of atopy. Allergy 2001;56:1172–9.
Commins SP, Satinover SM, Hosen J, Mozena J, Borish L, Lewis BD, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol 2009;123:426–33.
Nunez R, Carballada F, Gonzalez-Quintela A, Gomez-Rial J, Boquete M, Vidal C. Delayed mammalian meat-induced anaphylaxis due to galactose-α-1,3-galactose in 5 European patients. J Allergy Clin Immunol 2011;128:1122–4.
Morisset M, Richard C, Astier C, Jacquenet S, Croizier A, Beaudouin E, et al. Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose. Allergy 2012;67:699–704.
Sakaguchi M, Hori H, Hattori S, Irie S, Imai A, Yanagida M, et al. IgE reactivity to alpha1 and alpha2 chains of bovine type 1 collagen in children with bovine gelatin allergy. J Allergy Clin Immunol 1999;104:695–9.
Mullins RJ, James H, Platts-Mills TA, Commins S. Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galatose. J Allergy Clin Immunol 2012;129:1334–42.
Ayuso R, Lehrer SB, Lopez M, Reese G, Ibanez MD, Esteban MM, et al. Identification of bovine IgG as a major cross-reactive vertebrate meat allergen. Allergy 2000;55:348.54.
Ayuso R, Lehrer SB, Tanaka L, Ibanez MD, Pascual C, Burks AW, et al. IgE antibody response to vertebrate meat pro80 teins including tropomyosin. Ann Allergy Asthma Immunol 1999;83:399–405.
Pedrosa M, Boyano-Martínez T, García-Ara C, Quirce S. Shellfish Allergy: a Comprehensive Review. Clin Rev Allergy Immunol. 2014. [Epub ahead of print] PubMed PMID: 24870065.
Fuentes MM, Palacios R, Garcés M, Caballero ML, Moneo I. Isolation and characterization of a heat-resistant beef allergen: myoglobin. Allergy 2004;59:327–31.
Restani P, Fiocchi A, Beretta B, Velonà T, Giovannini M, Galli CL. Meat allergy: III-Proteins involved and cross-reactivity between different animal species. J Am Coll Nutr 1997;16:383–9.
Ferrer A, Marco FM, Andreu C, Sempere JM. Occupational asthma to carmine in a butcher. Int Arch Allergy Immunol 2005;138:243–50.
Mansfield LE, Bowers CH. Systemic reaction to papain in a nonoccupational setting. J Allergy Clin Immunol 1983;71:371–4.
Raison-Peyron N, Messaad D, Bousquet J, Demoly P. Anaphylaxis to beef in penicillin-allergic patient. Allergy 2001;56:796–7.
Chruszcz M, Mikolajczak K, Mank N, Majorek KA, Porebski PJ, Minor W. Serum albumins-unusual allergens. Biochim Biophys Acta 2013;1830:5375–81.
Spitzauer S, Pandjaitan B, Soregi G, Muhl S, Ebner C, Kraft D, et al. IgE cross-reactivities against albumins in patients allergic to animals. J Allergy Clin Immunol 1995;96:951–9.
Choi GS, Kim JH, Lee HN, Sung JM, Lee JW, Park HS. Occupational asthma caused by inhalation of bovine serum albumin powder. Allergy Asthma Immunol Res 2009;1:45–7.
Voltolini S, Spigno F, Cioè A, Cagnati P, Bignardi D, Minale P. Bovine Serum Albumin: a double allergy risk. Eur Ann Allergy Clin Immunol 2013;45:144–7.
Werfel SJ, Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic to cow’s milk. J. Allergy Clin Immunol 1997;99:293–300.
Martelli A, De Chiara A, Corvo M, Restani P, Fiocchi A. Beef allergy in children with cow’s milk allergy; cow’s milk allergy in children with beef allergy. Ann Allergy Asthma Immunol 2002;89:38–43.
Hilger C, Kohnen M, Grigioni F, Lehners C, Hentges F. Allergic cross-reactions between cat and pig serum albumin. Study at the protein and DNA levels. Allergy 1997;52:179–87.
Spitzauer S, Schweiger C, Sperr WR, Pandjaitan B, Valent P, Muhl S, et al. Molecular characterization of dog albumin as a cross-reactive allergen. J. Allergy Clin Immunol 1994,93:614–27.
Adamantos S, Chan DL, Goggs R, Humm K. Risk of immunologic reactions to human serum albumin solutions. J. Small Anim Pract 2009;50: 206.
Drouet M, Sabbah A. The pork/cat syndrome or crossed reactivity between cat epithelia and pork meat. Monogr Allergy 1996;32:164–73.
Drouet M, Sabbah A, Le Sellin J, Bonneau JC, Gay G, Dubois-Gosnet C. [Fatal anaphylaxis after eating wild boar meat in a patient with pork-cat syndrome]. Allerg Immunol (Paris) 2001;33:163–5.
Posthumus J, James HR, Lane CJ, Matos LA, Platts-Mills TAE, Commins SP. Initial description of pork-cat syndrome in the United States. J Allergy Clin Immunology 2013;131:923–5.
San-Juan S, Lezaun A, Caballero ML, Moneo I. Occupational allergy to raw beef due to cross-reactivity with dog epithelium. Allergy 2005;60:839–40.
Restani P, Ballabio C, Tripodi S, Fiocchi A. Meat allergy. Curr Opin Allergy Clin Immunol 2009;9:265–9.
Asero R, Mistrello G, Falagiani P. Oral allergy syndrome from pork. Allergy 1997;52(6):684–6.
Cisteró-Bahíma A, Enrique E, San Miguel-Moncín MM, Alonso R, Bartra J, Fernández-Parra B, et al. Meat allergy and cross-reactivity with hamster epithelium. Allergy 2003;58:161–2.
Hilger C, Swiontek K, Hentges F, Donnay C, de Blay F, Pauli G. Occupational inhalant allergy to pork followed by food allergy to pork and chicken: sensitization to hemoglobin and serum albumin. Int Arch Allergy Immunol 2010;151:173–8.
Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 1993;234:779–815.
Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M. „CHARMM: A program for macromolecular energy, minimization, and dynamics calculations“. J Comp Chem 1983;4:187–217.
Author information
Authors and Affiliations
Corresponding author
Additional information
Conflict of interest
The authors declare no conflict of interest.
Acknowledgment
The present work has been funded by the Ministry of Higher Education and Research in Luxembourg.
Cite this as
Morisset M, Arumugam K, Ollert M, Hilger C. Horse-meat allergy mediated by dog-allergy: a case report and review of the literature. Allergo J Int 2016; 25:76–81 DOI: 10.1007/s40629-016-0103-7
Rights and permissions
About this article
Cite this article
Morisset, M., Arumugam, K., Ollert, M. et al. Horse-meat allergy mediated by dog-allergy: a case report and review of the literature. Allergo J Int 25, 76–81 (2016). https://doi.org/10.1007/s40629-016-0109-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40629-016-0109-1