Experimental myocardial infarction in unanesthetized monkeys,☆☆

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Abstract

Experiments were undertaken to study myocardial infarction in non-human primates without the use of anesthetics or sedatives. During surgery, a snare was placed loosely around the left anterior descending coronary artery in 34 rhesus monkeys (Macaca mulatta). Several days later, myocardial infarction was studied from the moment it was induced. The technique was reproducible and the distribution of necrosis was fairly constant. Aortic flow, aortic blood pressure, left atrial pressure, and the ECG were monitored. A computer program for discriminant analysis, based on data obtained within 30 minutes after infarction, resulted in retrospective predictions of 100 per cent in animals dying from cardiogenic shock and in predictions of 93 per cent in surviving animals.

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    Supported by Contract PH-43-686 from the Artificial Heart-Myocardial Infarction Program of the National Heart and Lung Institute and by grant FR 00163 from the National Institutes of Health.

    ☆☆

    This is publication No. 565 of the Oregon Regional Primate Research Center.

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