Renal function after acyclovir intravenous injection
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Cited by (139)
Novel Insights to Enhance Therapeutics With Acyclovir in the Management of Herpes Simplex Encephalitis
2021, Journal of Pharmaceutical SciencesCitation Excerpt :Acyclovir crystalluria has also been reported in urinary sediment (needle-like crystals) of patients receiving IV acyclovir infusion at the dosage of 500 mg/m2 8-hourly as a 1-h infusion.78 Minimal histologic changes are seen in these trials and the changes are completely reversible on cessation of treatment.80 Dose adjustment is necessary when IV acyclovir is given to patients with end-stage renal disease to avoid drug accumulation, which is based on creatinine clearance.26,74,75
Acute kidney injury (AKI) associated with intravenous aciclovir in adults: Incidence and risk factors in clinical practice
2018, International Journal of Infectious DiseasesCitation Excerpt :A binomial logistic regression model (Χ2 = 19.2, P < 0.001) indicated that daily dose (OR 2.4 per gram [95% CI: 1.3–4.5] P = 0.005) and CKD (OR 9.5 [95% CI: 2.3–39.3] P = 0.002) were independent risk factors. The rate of aciclovir-associated AKI reported here is consistent with previous reports (Brigden et al., 1982; Sawyer et al., 1988; Rao et al., 2015; Pierson-Marchandise et al., 2017) indicating that in contemporary clinical practice, aciclovir is comparable to other more widely-perceived nephrotoxic antimicrobials such as gentamicin (Paquette et al., 2015) or vancomycin (van Hal et al., 2013). Unlike other antivirals, aciclovir does not compete with creatinine for tubular excretion (Gunness et al., 2010), therefore the elevations in serum creatinine we observe are a true reflection of renal damage.
Acyclovir-induced nephrotoxicity in a pregnant woman with chickenpox
2016, Taiwanese Journal of Obstetrics and GynecologyAcyclovir induced hypokalemia
2013, Journal of Clinical VirologyAcyclovir-Induced Nephrotoxicity in Adults with Viral Encephalitis
2024, Journal of the College of Physicians and Surgeons Pakistan
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From the Wellcome Research Laboratories, Beckenham, Kent, England.