Serum gonadotropin and steroid patterns during the normal menstrual cycle☆
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2020, Molecular and Cellular EndocrinologyCitation Excerpt :Although the underlying mechanisms regulating the changes in FSH isoforms during puberty remain unclear, changes in GnRH secretory pattern, circulating concentrations of gonadal steroids, and endocrine or paracrine effects of protein regulators are all suspects (Ulloa-Aguirre et al., 1995). The reduction in circulating levels of estradiol, progesteroneand inhibin A in the beginning of the menstrual cycle due to the demise of the corpus luteum reduces the inhibitory effects on the pituitary and allows FSH to rise in the early follicular phase and stimulate follicular growth and selection (Lee et al., 1988; Mishell et al., 1971; Yding Andersen, 2017). At approximately Day 7 of the menstrual cycle, when selection of the dominant follicle occurs, FSH concentrations have already peaked and started to decline, with a continued slow decline until ovulation occurs (Lee et al., 1988; Yding Andersen, 2017).
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Presented at the 18th Annual Meeting of the Pacific Coast Fertility Society, Scottsdale, Arizona, October 30, 1970. Supported by a grant from The Ford Foundation.