Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F in endometriosis,☆☆

https://doi.org/10.1016/0002-9378(81)90033-8Get rights and content

Abstract

An anatomic basis for the infertility associated with endometriosis is often lacking. The present study measured peritoneal fluid levels of two of the stable products of prostaglandin endoperoxides (thromboxane B2 and 6-keto-prostaglandin F) in patients with and without endometriosis. Both compounds were significantly elevated in the endometriosis group (n = 15, p < 0.05). This suggests an increase in the peritoneal fluid levels of thromboxane A2 and prostacyclin, both of which could act on tubal smooth muscle and interfere with tubal function. Such altered tubal function might explain the phenomenon of endometriosis-induced infertility when there is no direct damage to the reproductive organs.

References (15)

There are more references available in the full text version of this article.

Cited by (120)

  • Comparison of endometrial prostanoid profiles in three infertile subgroups: the missing part of receptivity?

    2020, Fertility and Sterility
    Citation Excerpt :

    This study was performed on rats. With this study, the question about the potential relationship between prostanoid and implantation/infertility was raised and it was in 1981 when the first paper assessing prostanoids in infertile women was released: TXB2 was found increased in the peritoneal fluid of infertile women with endometriosis (10). A literature search revealed numerous studies on prostaglandins and their role in implantation.

  • Uterine wall thickness at the second trimester can predict subsequent preterm delivery in pregnancies with adenomyosis

    2019, Taiwanese Journal of Obstetrics and Gynecology
    Citation Excerpt :

    An inflammatory process observed in adenomyosis has been implicated as a biochemical mechanism in preterm labor, preterm premature rupture of membranes (PPROM), and preterm delivery in pregnancies with adenomyosis. Higher prostaglandin (PG) level was found in adenomyosis tissue and the peritoneal fluid of women with endometriosis or adenomyosis [11–13]. PG contributes to uterine irritability and induction of uterine contractions causing preterm labor [14].

  • Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers

    2012, Fertility and Sterility
    Citation Excerpt :

    Inflammation is associated with the activation of resident macrophages, mast cells, and fibroblasts, all of which produce large quantities of proangiogenic factors (38, 39). Mast cell–derived modulators of the microvascular function include histamine, heparin, VEGF, nitric oxide, cytokines, chemokines, proteases, and lipid mediators (36–49). Some of these mediators have been shown to contribute to inflammation-induced permeability responses in a variety of animal models.

  • A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions

    2009, Fertility and Sterility
    Citation Excerpt :

    Furthermore, evidence seems to suggest that these endometriosis-associated nerve fibers are of a new origin (9). The peritoneal endometriotic lesions are able to produce several pain-mediating substances, such as prostaglandins (PG) like PG E2 and F2α, histamine, kinins, NGF, and interleukins, which can activate peritoneal nociceptors (2, 24–26). However, there is no direct or indirect evidence that peritoneal endometriosis-associated nerve fibers are involved in conduction of endometriosis-related pain.

  • Pyruvate reduces in vitro the embryotoxic effect of peritoneal fluid from infertile women with endometriosis

    2008, European Journal of Obstetrics and Gynecology and Reproductive Biology
    Citation Excerpt :

    Peritoneal fluid has been shown to contain a plethora of substances, including cytokines, complement components (C3 and C4), growth factors, and prostaglandins [21]. Factors in the peritoneal fluid that have been reported to have a potential to inhibit early embryo growth include IL-1 [17,22], TNF-( [17], IL-6 [5] prostaglandins [23], ovum capture inhibitor (OCI) [24], and nitric oxide [25]. At present, neither the target of the embryotoxic factor(s) nor its mode of action in vivo is clear.

View all citing articles on Scopus

Supported through funds provided by the Bureau of Medicine and Surgery, Navy Department, C.I. 0-06-1292.

☆☆

The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department or the naval service at large.

View full text