Perineural lymphatics: Myth or fact

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Abstract

A number of experiments designed to determine the mechanism of tumor extension along nerves are described together with clinical observations. The data presented indicate that perineural lymphatics are a myth and not a fact for the following reasons. (1) Lymphatics do not drain into nerves. (2) Perineurial spaces do not flow into lymphatics. (3) Intraneural injection of tumor cells in the rat and clinical observations concerning tumor extension along nerves show that tumor patterns are not compatible with lymphatic spread. (4) Special studies, including electron microscopy, indicate that there are no lymphatics within nerves.

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This work was aided by Grant P-409 from the American Cancer Society.

1

From the Division of Plastic and Maxillofacial Surgery, Departments of Pathology and Neuroanatomy, The University of Texas Medical Branch, Galveston, Texas.

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