Scientific paperIntraoperative identification of parathyroid glands: Appraisal of methylene blue staining
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Cited by (44)
Confirmation of Parathyroid Tissue: Are Surgeons Aware of New and Novel Techniques?
2020, Journal of Surgical ResearchCitation Excerpt :These include gamma probe for intraoperative nuclear mapping, which involves coordination with nuclear medicine for the injection of technetium-99m and intraoperative use of a gamma probe,11,12 and intravenous injection of methylene blue, which results in staining of parathyroid glands. However, this technique may result in staining of other tissues or result in side effects including neurotoxicity in patients on serotonin receptor inhibitors.13,14 Given the variety of methods available for intraoperative confirmation of parathyroid tissue, we hypothesized that there would be variability in intraoperative techniques for parathyroid identification/confirmation among members of the American Association of Endocrine Surgeons (AAES).
Directed molecular assembly into a biocompatible photosensitizing nanocomplex for locoregional photodynamic therapy
2015, Journal of Controlled ReleaseCitation Excerpt :Water-soluble phenothiazinium compounds such as methylene blue (MB) are another potent family of photosensitizer. With high water solubility and biosafety, MB has widely been used in the clinic for a variety of purposes [9–11]. As a potential PDT drug, it has merits of high molar extinction coefficient and suitable 1O2 generation quantum yield in the therapeutic near-infrared (NIR) optical window as well as minimal dark toxicity [12,13].
The role of methylene blue in serotonin syndrome: A systematic review
2010, PsychosomaticsCitation Excerpt :Symptoms were frequently severe, with several patients admitted to the ICU. Although the safety of intravenous MB has been previously established in general-surgical patients,1,2 its use among patients taking SRIs resulted in a 38% incidence of neuropsychiatric complications. There is both clinical and pharmacological evidence to suggest that the postoperative complications described above could be explained by a diagnosis of serotonin syndrome.
Role of nitric oxide production in anaphylaxis and its relevance for the treatment of anaphylactic hypotension with methylene blue
2007, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :Methylene blue has also been reported to cause methemoglobinemia.89-91 In humans, methylene blue is used at a dose of 5 to 7.5 mg/kg during parathyroid surgery to visualize the parathyroid glands.92-97 This dose is usually well tolerated.
Fluorescence-Guided Minimally Invasive Parathyroidectomy: A Novel Surgical Therapy for Secondary Hyperparathyroidism
2006, American Journal of Kidney DiseasesRapid intraoperative localization of parathyroid glands utilizing methylene blue infusion
2004, Otolaryngology - Head and Neck Surgery
- 1
From the Llandough Hospital and the University Hospital of Wales, Cardiff, South Glamorgan, Wales.