Original articleOverview of the nature of vasoconstriction in arterial grafts for coronary operations
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2016, Annals of Thoracic SurgeryCitation Excerpt :In general, vasoconstriction may be evoked by a number of stimulants including mechanical and/or nerve stimulation, as well as vasoconstrictor substances (spasmogens) [12, 59]. Spasmogens in arterial grafts are well studied and include endothelium-derived contracting factors (eg, endothelin-1 [59, 60]), prostaglandins (eg, thromboxane A2 or its mimetic PGF2α), α-adrenoceptor agonists (eg, norepinephrine, methoxamine, and phenylephrine), platelet-derived substances (eg, 5-hydroxytryptamine), and the cellular membrane-depolarizing agent potassium [59], as well as mast cells and histamine [61]. It should also be noted that there are marked differences between human and animal vessels in response to these spasmogens [12, 62].
Copyright © 1995 Published by Elsevier Inc.