Purification of interleukin-1β converting enzyme, the protease that cleaves the interleukin-1β precursor
References (20)
- et al.
Immunol. Today
(1990) - et al.
FEBS Lett
(1989) - et al.
J. Biol. Chem
(1990) - et al.
J. Biol. Chem
(1989) - et al.
J. Biol. Chem
(1988) Anal. Biochem
(1976)- et al.
Anal. Biochem
(1980) J. Biol. Chem
(1987)- et al.
Immunol. Today
(1982) Rev. Infect. Dis
(1984)
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Pathogenesis of Osteoarthritis
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth EditionEndoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells
2012, Journal of Biological ChemistryCitation Excerpt :Caspases-3 and -8 are known to play a pivotal role in programmed cell death. However, the cleavage of RBX1 by caspase-1 was surprising, because this enzyme belongs to the inflammatory caspases that primarily engage in the cleavage of the proform of IL-1β (30) and IL-18 (31, 32). To elucidate the possible role of caspase-1 in the cleavage of Rbx1 in primary B cells, we analyzed splenic B cells from caspase-1 knock-out mice.
Pathogenesis of Osteoarthritis
2012, Kelley's Textbook of Rheumatology: Volume 1-2, Ninth EditionRhein: A potential biological therapeutic drug for intervertebral disc degeneration
2011, Medical HypothesesCitation Excerpt :Accumulating evidence has shown that pro-inflammatory cytokines play important roles in cartilage degradation in OA [24,25]. One of these cytokines is interleukin-1 (IL-1) which stimulates the degradation process and suppresses cartilage-matrix synthesis [26]. RH can directly inhibit the synthesis and activity of IL-1β, and diminish IL-1β induced secretion of matrix metalloproteinases (MMPs) and aggrecanases, thereby preventing the breakdown of cartilage [27,28].
Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials
2010, Osteoarthritis and CartilageCitation Excerpt :There is strong evidence of a contribution of additional pro-inflammatory cytokines to cartilage degradation in OA9–12. One of these is interleukin-1 (IL-1) which stimulates the degradation process and suppresses cartilage-matrix synthesis, with the overall result of a severe degradation of cartilage and following appearance of conditions known to be characteristic of OA13. A further finding, which may increase the deleterious effect of IL-1, is that human OA cartilage may be more responsive to IL-1 than healthy cartilage14,15.
Biologics in development for rheumatoid arthritis: Relevance to osteoarthritis
2006, Advanced Drug Delivery Reviews