A novel biologically active seleno-organic compound—1: Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen)
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2022, Hearing ResearchCitation Excerpt :Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) a synthetic seleno-organic drug molecule with anti-inflammatory and antioxidant activities has been investigated as a possible treatment for a range of indications including hearing loss and tinnitus. With a glutathione peroxidase-like activity (Müller et al., 1984), ebselen treatment of rat organ of Corti explants in vitro resulted in protection of hair cells from damage (Kopke et al., 1997). Oral treatment for 7 days post intratympanic injection of gentamicin protected guinea pig organ of Corti from ototoxic effects (Takumida et al., 1999).
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