A novel biologically active seleno-organic compound—1: Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen)

doi:10.1016/0006-2952(84)90083-2

Biochemical Pharmacology

Volume 33, Issue 20, 15 October 1984, Pages 3235-3239

https://doi.org/10.1016/0006-2952(84)90083-2 Get rights and content

Abstract

A synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51), exhibits GSH peroxidase-like activity in vitro, in contrast to its sulfur analog, PZ 25. In addition, PZ 51 behaves as an antioxidant shown by a temporary protection of rat liver microsomes against ascorbate/ ADP-Fe-induced lipid peroxidation, an effect also elicited by PZ 25 but to a smaller extent. This protection against lipid peroxidation is independent of GSH and of P-450 monooxygenase activity.

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A novel biologically active seleno-organic compound—1: Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen)

Abstract

FEBS Lett.

Biochim. biophys. Acta

J. biol. Chem.

Meth. Enzymol.

Meth. Enzymol.

FEBS Lett.

Biochim. biophys. Acta

Archs. Biochem. Biophys.

Biochim. biophys. Res. Commun.