Antiestrogens and steroid hormones: Substrates of the human P-glycoprotein
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Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients
2023, Acta Pharmaceutica Sinica BDose-dependent effects of Hedyotis diffusa extract on the pharmacokinetics of tamoxifen, 4-hydroxytamoxifen, and N-desmethyltamoxifen
2022, Biomedicine and PharmacotherapyInnate Immunity in the CNS: Redefining the relationship between the CNS and its Environment
2013, NeuronCitation Excerpt :In parallel, several proinflammatory molecules are substrates of ABC transporters, implicating the latter directly in the immune response. For instance, ABCB1 has been shown to be involved in transporting the platelet-activating factor (PAF), steroids, and sphingosine-1-phosphate (S1P) (Honig et al., 2003; Rao et al., 1994; Raggers et al., 2001). In addition, systemic inflammation may affect the BBB function even before extravasation of immune cells.
Multidrug resistance: Physiological principles and nanomedical solutions
2013, Advanced Drug Delivery ReviewsCitation Excerpt :Significant effort has been put in identifying the endogenous substrates of MDR proteins, in order to elucidate their physiological role. No natural ABCB1 substrates have been identified thus far, at least not in vivo, although this protein has been shown to be able to transport certain steroid hormones [67] and cytokines [68]. Some additional light was shed on this by analyses in animal models.