Research paperFish oil fatty acids and human platelets: Dose-dependent decrease in dienoic and increase in trienoic thromboxane generation☆
References (36)
- et al.
The conversion of dietary eicosapentaenoic acid to prostanoids and leukotrienes in man
Prog Lipid Res
(1986) - et al.
Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?
Lancet
(1978) - et al.
The prostacyclin/thromboxane balance is favourably shifted in Greenland eskimos
Prostaglandins
(1986) - et al.
Different metabolic behavior of long-chain n-3 polyunsaturated fatty acids in human platelets.
Biochim Biophys Acta
(1988) - et al.
Trans n-3 eicosapentaenoic and docosahexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets compared to the respective cis fatty acids
J Lipid Res
(1990) - et al.
Modulation of prostanoid formation by various polyunsaturated fatty acids during platelet-endothelial cell interactions
Prostagl Leukotr Essent Fatty Acids
(1990) - et al.
Enrichment of platelet phospholipids with eicosapentaenoic acid and docosahexaenoic acid inhibits thromboxane A2/prostaglandin H2 receptor binding and function
J Biol Chem
(1990) - et al.
Changes in fatty acid composition in rat blood and organs after infusion of docosahexaenoic acid ethyl ester
Am J Clin Nutr
(1991) - et al.
The infusion of trieicosapentaenoyl-glycerol into humans and the in vivo formation of prostaglandin 13 and thromboxane A3
Biochem Biophys Res Commun
(1988) - et al.
Infusion of fish oil emulsion: effects on platelet aggregation and fatty acid composition in phospholipids of plasma, platelets, and red blood cell membranes in rabbits
Am J Clin Nutr
(1987)
Infusion of emulsified trieicosapentaenoylglycerol into rabbits—the effects on platelet aggregation, polymorphonuclear leukocyte adhesion, and fatty acid composition in plasma and platelet phospholipids
Thromb Res
Analysis of 2- and 3-series prostanoids by post-HPLC-ELISA
Anal Biochem
Medical progress. Cardiovascular effects of n-3 fatty acids
N Engl J Med
Long-term effects of dietary marine n-3 fatty acids upon plasma and cellular lipids, platelet function and eicosanoid formation in humans
J Clin Invest
Dietary n-6 fatty acids inhibit the incorporation of dietary n-3 fatty acids in thrombocyte and serum phospholipids in humans: a controlled dietetic study
Scand. J Clin Lab Invest
Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties
Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2- versus 3-series prostanoid generation
J Pharmacol Exp Ther
Eicosapentaenoic acid interferes with U46619-stimulated formation of inositol phosphates in washed rabbit platelets
Thromb Hemostas
Cited by (74)
Role of cytochrome P450-epoxygenase and soluble epoxide hydrolase in the regulation of vascular response
2023, Advances in PharmacologyImpact of the eicosapentaenoic acid to arachidonic acid ratio on plaque characteristics in statin-treated patients with coronary artery disease
2023, Journal of Clinical LipidologyCitation Excerpt :A low eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is an indicator of increased risk for cardiovascular events.1,2 Preclinical and clinical studies have demonstrated that EPA stabilizes plaques by inducing an anti-inflammatory response and reducing platelet aggregation.3,4,5 In contrast, AA facilitates plaque instability through the activation of inflammatory processes and platelet activation.6,7
Crosstalk between adenosine receptors and CYP450-derived oxylipins in the modulation of cardiovascular, including coronary reactive hyperemic response
2022, Pharmacology and TherapeuticsCitation Excerpt :But, sEH inhibition by using AUDA effects of EpOME/DiHOME ratio improved renal recovery in response to ischemia/reperfusion injury in C57BL/6 mice (Lee et al., 2012) (Table S6). LA gets metabolized through CYP450-epoxygenases to form hydroxyl-LA metabolites (9-, 13-hydroxyoctadecadienoic acids [9-HODE and 13-HODEs]) (Hanif et al., 2016a; Hanif et al., 2017; Konkel & Schunck, 2011; Tam, 2013; Thuresson et al., 2000), and the HODEs were associated with oxidative stress and the 9-HODE was involved in inducing macrophage IL-1β (Folcik & Cathcart, 1994; Honn et al., 1992; Kramer et al., 1996). Interestingly, 9- and 13-HODEs stimulate plasminogen activator inhibitor type-1 involving PPARγ in endothelial cells, and 13-HODE has anti-inflammatory activity with PPARγ-agonist in inflammatory diseases (Altmann et al., 2007; Belvisi & Mitchell, 2009; Emerson & LeVine, 2004; Fritsche, 2008; Marmol et al., 1999; Stoll et al., 1994).
Lipid Mediators in Cardiovascular Physiology and Disease
2022, Cardiovascular Signaling in Health and DiseaseEfficacy and Safety of Omega-3 Fatty Acids in the Prevention of Cardiovascular Disease: A Systematic Review and Meta-analysis
2022, Cardiovascular Drugs and TherapyIcosapent ethyl for reduction of persistent cardiovascular risk: a critical review of major medical society guidelines and statements
2022, Expert Review of Cardiovascular Therapy
- ☆
We thank Dr. J. Mollenhauer and Prof. K. Brune, Erlangen (Germany) for supplying the monoclonal anti-Tx antibody, F. Michnacs for excellent technical assistance and Dr. R. Snipes for thorough linguistic editing of the manuscript.
- ∗
This manuscript includes portions of a doctoral thesis by J. Stevens.