Elsevier

Brain Research

Volume 409, Issue 2, 21 April 1987, Pages 343-349
Brain Research

Pineal gland in old age; quantitative and qualitative morphological study of 168 human autopsy cases

https://doi.org/10.1016/0006-8993(87)90720-7Get rights and content

Abstract

Age-related changes of human pineal gland were studied morphologically on 168 autopsy cases. Pineal weight in the formalin-fixed condition was99 ±56mg in males (n=88, mean age 78 years) and 91±41mg in females (n=80, mean age 79 years), which showed no sexual difference (P=0.290). There was no correlation between pineal weight and age of the patient (r=−0.0678, P=0.191, n=168). The pineal volume calculated as a spheroid was directly proportional to the weight (r=0.904, n=167, P=0.000). A significant correlation existed between pineal weight and the degree of calcification (r=0.231, P=0.002, n=156). The density of the pineals decreased with age (r=−0.164, P=0.017, n=167). The degree of calcification and cyst formation did not increase with age, but the grade of cyst formation was related to the pineal volume (P=0.0002). Some pineals of the patients over 90 years old showed no calcification and appeared indistinguishable from the ones of the younger subjects. The weight and volume of the pineals of the patients with hypertension was appreciably greater than those of the non-hypertensive patients. These results indicate that human pineals do not necessarily degenerate progressively after involution.

References (29)

  • HasegawaA.

    Age-related changes of mouse pinealocytes: electron microscopy and morphometry (in Japanese)

    Shinkei Kenkyu no Shinpo

    (1984)
  • KapperJ.A.

    The development, topographical relations and innervation of the epihysis cerebri in the albino rat

    Z. Zellforsch

    (1960)
  • LangU. et al.

    Radioimmunological determination of urinary melatonin in humans: Correlation with plasma levels and typical 24-hour rhythmicity

    J. Clin. Endocrinol. Metab.

    (1981)
  • OkuderaH. et al.

    Evaluation of the intracranial calcification associated with aging on computed tomography (in Japanese)

    Brain and Nerve

    (1986)
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