Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect

doi:10.1016/0006-8993(89)91691-0

Brain Research

Volume 503, Issue 2, 4 December 1989, Pages 354-357

https://doi.org/10.1016/0006-8993(89)91691-0 Get rights and content

Abstract

Ongoing studies from this laboratory have demonstrated marked potentiating actions of the sex steroid 17β-estradiol (E₂) on glutamate-induced excitation. In the present study, systemic injection of a physiological dose fo E₂ was demonstrated to augment significantly excitatory responses of cerebellar Purkinje (Pnj) cells to iontophoretic application of the specific excitatory amino acid (e.a.a.) agonists quisqualate and $N- methyl- d -aspartate$ . Potentiation of e.a.a. responses was observed as rapidly as 5–10 min post E₂, and was, in many cases, a persistent, non-decremental effect. These observed long-term actions of E₂ may provide one mechanism for the activating effects of the steroid on sensorimotor function and acitivity.

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^☆: This work was supported by NIH Grant NS25809.

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Short communicationEstrogen administration increases neuronal responses to excitatory amino acids as a long-term effect☆

Abstract

Neurosci. Lett.

Horm. Behav.

Pharmacol. Biochem. Behav.

Brain Res. Rev.

Brain Research

Neurosci. Lett.

Neurosci. Lett.

Brain Res, Bull.

Brain Research

Brain Research

Neurosci. Lett.

Brain Research

Brain Research

Brain Research

Life Sci.

J. Steroid Biochem.

Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path

J. Physiol. (Lond.)

Short communication
Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect☆