Blockade of lipopolysaccharide-induced fever by subdiaphragmatic vagotomy in guinea pigs
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Bupleurum chinense exerts a mild antipyretic effect on LPS-induced pyrexia rats involving inhibition of peripheral TNF-α production
2023, Journal of EthnopharmacologyBody thermal responses and the vagus nerve
2019, Neuroscience LettersCitation Excerpt :In rats, subdiaphragmatic vagotomy attenuated or eliminated IL-1β or LPS-triggered hyperthermia [78,109,110]. Similar results were observed in guinea pigs [36,92]. Later, numerous contradictory evidences that support or against the role of the vagus nerve in pyrogen-induced fever were reported.
Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication
2016, Brain, Behavior, and ImmunityThe OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension
2015, Journal of NeuroimmunologyCitation Excerpt :Together, these data suggest that the ‘cut off’ for vagal mediation of LPS hypotension is between 5 and 15 mg/kg LPS. These experiments were predicated on extensive evidence that the mechanism responsible for the thermoregulatory effects of LPS and cytokines is dose-dependent: very low LPS doses (1 μg/kg i.v.) cause fever by activating vagus nerve afferents whereas higher doses (30 μg/kg i.v.) activate receptors in the OVLT, area postrema and, perhaps, other circumventricular organs (Sehic and Blatteis, 1996; Romanovsky et al., 1997, 2005; Hansen et al., 2001; Blatteis et al., 2005). The vagus nerve is also thought to mediate some of the behavioral and endocrine effects of LPS.
Chronic fatigue syndrome from vagus nerve infection: A psychoneuroimmunological hypothesis
2013, Medical Hypotheses